Erectile Dysfunction Treatments

ERECTILE DYSFUNCTION TREATMENTS
Generic Brand Form Strength Onset Duration
of Action
Dosing Considerations
PDE-5 INHIBITORS
avanafil Stendra tabs 50mg,
100mg,
200mg
30−45min
(fasted state)
5hrs

• Initially 100mg 15min before sexual activity.

• Max 200mg once daily.

Concomitant moderate CYP3A4 inhibitors: Max 50mg once daily.

Concomitant α-blockers: Initially 50mg once daily.

sildenafil Viagra tabs 25mg,
50mg,
100mg
0.5−2hrs
(1hr)
4hrs

• Usually 25−100mg 1hr before anticipated sexual activity.

>65yrs old: Initially 25mg.

Severe renal dysfunction (CrCl<30mL/min): Initially 25mg.

Hepatic impairment: Initially 25mg.

Ketoconazole, itraconazole, erythromycin, saquinavir: Initially 25mg.

Ritonavir: Max 25mg every 48hrs.

α-blockers: Initially 25mg.

tadalafil Cialis tabs 2.5mg,
5mg,
10mg,
20mg
0.5−6hrs
(2hrs)
36hrs

Use as Needed:

• Usually 5−20mg before anticipated sexual activity.

>65yrs old: No adjustment needed.

Moderate renal dysfunction (CrCl 30−50mL/min): Initially 5mg; max 10mg/48hrs.

Severe renal dysfunction (CrCl<30mL/min): Max 5mg/72hrs.

Mild or moderate hepatic impairment: Max 10mg daily; severe: Not recommended.

Ketoconazole, ritonavir: Max 10mg every 72hrs.

α-blockers: Lowest recommended dose.

see literature

Once−Daily Use:

• Initially 2.5mg (taken at same time each day); may increase to 5mg/day.

Severe renal dysfunction (CrCl<30mL/min): Not recommended.

Mild or moderate hepatic impairment: Use caution; severe: Not recommended.

Concomitant potent CYP3A4 inhibitors: Max 2.5mg.

For ED + BPH: 5mg taken at same time once daily without regard to timing of sexual activity.

varden-
afil
Levitra tabs 2.5mg,
5mg,
10mg,
20mg
0.5−2hrs
(1hr)
4hrs

• Usually 5−20mg 1hr before anticipated sexual activity.

>65yrs old: Initially 5mg.

Renal dysfunction: No adjustment needed.

Mild hepatic impairment: No adjustment. Moderate: Max 10mg. Severe: Not recommended.

Ketoconazole or itraconazole 200mg/day, or erythromycin: Max 5mg daily. Ketoconazole or itraconazole 400mg/day, clarithromycin, saquinavir, atazanavir or indinavir: max 2.5mg daily. Ritonavir: Max 2.5mg every 72hrs.

α-blockers: Initially 5mg.

Staxyn orally disinte-
grating tabs
10mg 0.75−2.5hrs
(1.5hr)
4−6hrs

• Take as needed approximately 60min before sexual activity; max: 10mg/day.

• Not interchangeable with Levitra 10mg.

• Do not take with water. Place on tongue to disintegrate.

Moderate to severe hepatic impairment or renal dialysis: Not recommended.

Concomitant moderate-to-potent CYP3A4 inhibitors, α-blockers, or other erectile dysfunction treatments: Not recommended.

PROSTAGLANDIN E1
alpros-
tadil
Caverject injection, intraca-
vernous
5mcg,
10mcg,
20mcg,
40mcg
5−20min 1hr

• Usually 1.25−60mcg within 1hr before anticipated sexual activity.

• Max 3 inj/wk with a 24‑hr period between each injection.

Edex injection, intraca-
vernous
10mcg,
20mcg,
40mcg
7min 1hr

• Usually 1−40mcg within 1hr before anticipated sexual activity.

• Max of 3 inj/wk with a 24‑hr period between each injection.

Muse supposi-
tory, urethral
125mcg,
250mcg,
500mcg,
1000mcg
5−10min 0.5−1hr

• Initially 125−250mcg.

• Max 2 systems/24hrs.

(Rev. 11/2014)

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