Diabetes Treatments

DIABETES TREATMENTS
Generic Brand Strength Form Usual
Maintenance
Range
Usual Max Dose
ALPHA-GLUCOSIDASE INHIBITOR
acarbose Precose 25mg, 50mg, 100mg tabs 50−100mg three
times daily
≤60kg: 150mg/day in 3 divided doses
>60kg: 300mg/day in 3 divided doses
miglitol Glyset 25mg, 50mg, 100mg tabs 50mg three times daily 300mg/day in 3 divided doses
AMINO ACID DERIVATIVE
nateglinide Starlix 60mg, 120mg tabs 120mg 1−30min before meals three times daily 360mg/day in 3 divided doses
AMYLIN ANALOGUE/AMYLINOMIMETIC
pramlintide Symlin 0.1mg/mL injectable soln Type 1:
 
30−60mcg
Type 2: 
 
60−120mcg
BIGUANIDE
metformin Fortamet 500mg, 1000mg ext‑rel tabs 500mg–2.5g once daily 2.5g/day
Glucophage 500mg, 850mg, 1000mg tabs 500mg–2.55g in 2 or 3 divided doses 2.55g/day
Glucophage XR 500mg, 750mg ext‑rel tabs 500mg−2g in single or 2 divided doses 2g in single or in 2 divided doses
Glumetza 500mg, 1000mg ext‑rel tabs 500mg−2g once daily 2g/day
Riomet 500mg/5mL oral soln 500mg–2.55g (5−25.5mL) in 2−3 divided doses 2.55g/day (25.5mL/day)
BILE ACID SEQUESTRANT
colesevelam Welchol 625mg tabs 6 tabs once daily or 3 tabs twice daily 4.5g/day
Welchol for Oral Suspension 3.75g pwd pkts One 3.75g pkt once daily
DIPEPTIDYL PEPTIDASE-4 INHIBITOR
alogliptin Nesina 6.25mg, 12.5mg, 25mg tabs 25mg once daily
linagliptin Tradjenta 5mg tabs 5mg once daily
saxagliptin Onglyza 2.5mg, 5mg tabs 2.5mg or 5mg once daily
sitagliptin Januvia 25mg, 50mg, 100mg tabs 100mg once daily
DIPEPTIDYL PEPTIDASE-4 INHIBITOR + BIGUANIDE
alogliptin/
metformin
Kazano 12.5mg/500mg, 12.5mg/1000mg tabs 25mg/2000mg per day in divided doses
linagliptin/
metformin
Jentadueto 2.5mg/500mg, 2.5mg/850mg, 2.5mg/1000mg tabs 2.5mg/1000mg twice daily
saxagliptin/
metformin HCl ext‑rel
Kombiglyze XR 5mg/500mg, 5mg/1000mg, 2.5mg/1000mg tabs 5mg/2g per day
sitagliptin/
metformin
Janumet 50mg/500mg, 50mg/1000mg tabs 100mg/2g per day
Janumet XR 50mg/500mg, 50mg/1000mg, 100mg/1000mg ext‑rel tabs
DIPEPTIDYL PEPTIDASE-4 INHIBITOR + THIAZOLIDINEDIONE
alogliptin/
pioglitazone
Oseni 12.5mg/15mg, 12.5mg/30mg, 12.5mg/45mg, 25mg/15mg, 25mg/30mg, 25mg/45mg tabs 25mg/45mg per day
DOPAMINE RECEPTOR AGONIST
bromocriptine Cycloset 0.8mg tabs 1.6−4.8mg/
 
day
4.8mg/day
 
 
Generic Brand Strength Form Usual
Maintenance
Range
Usual Max Dose
GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST
albiglutide Tanzeum 30mg, 50mg injectable soln 30−50mg once weekly
dulaglutide Trulicity 0.75mg/0.5mL, 1.5mg/0.5mL injectable soln 0.75mg−1.5mg once weekly 1.5mg once weekly
exenatide Byetta 250mcg/mL injectable soln 5−10mcg twice daily 10mcg twice daily
exenatide ext‑rel Bydureon 2mg injectable soln 2mg once every 7 days
liraglutide [rDNA origin] Victoza 6mg/mL injectable soln 0.6−1.8mg/
 
day
MEGLITINIDE
repaglinide Prandin 0.5mg, 1mg, 2mg tabs 0.5−4mg within 30min of meals 2−4 times daily 16mg/day
MEGLITINIDE + BIGUANIDE
repaglinide/
metformin
PrandiMet 1mg/500mg,
2mg/500mg
tabs 4mg/1000mg per meal
10mg/2500mg per day
SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITOR
canagliflozin Invokana 100mg, 300mg tabs 100−300mg once daily
dapagliflozin Farxiga 5mg, 10mg tabs 5−10mg once daily in AM
empagliflozin Jardiance 10mg, 25mg tabs 10−25mg once daily 25mg once daily
SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITOR + BIGUANIDE
canagliflozin/
metformin 
HCl
Invokamet 50mg/500mg, 50mg/1000mg, 150mg/500mg, 150mg/1000mg tabs 300mg/2000mg per day
dapagliflozin/
metformin HCl ext‑rel
Xigduo XR 5mg/500mg, 5mg/1000mg, 10mg/500mg, 10mg/1000mg tabs 10mg/2000mg per day
SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITOR + DIPEPTIDYL PEPTIDASE‑4 INHIBITOR
empagliflozin/
linagliptin
Glyxambi 10mg/5mg, 25mg/5mg tabs 10mg/5mg once daily 25mg/5mg once daily
SULFONYLUREA
chlorpro-
pamide
1st generation
Diabinese 100mg, 250mg scored tabs 250−750mg in single or divided doses 750mg/day in single or divided doses
glimepiride Amaryl 1mg, 2mg, 4mg scored tabs 1−4mg once daily 8mg/day
glipizide
2nd generation
Glucotrol 5mg, 10mg scored tabs 5−15mg once daily or 5−40mg in divided doses 15mg once daily or 40mg in divided doses
Glucotrol 
XL
2.5mg, 5mg, 10mg ext‑rel tabs 5−10mg once daily 20mg/day
glyburide
2nd generation
Diabeta 1.25mg, 2.5mg, 5mg scored tabs 1.25−20mg in single or divided doses 20mg/day in single or divided doses
glyburide, micronized
2nd generation
Glynase PresTab 1.5mg, 3mg, 6mg scored tabs 0.75−12mg in single or divided doses 12mg/day in divided doses
SULFONYLUREA + BIGUANIDE
glipizide/
metformin
2.5mg/250mg,
2.5mg/500mg,
5mg/500mg
tabs 20mg/2000mg per day in single or divided doses
glyburide/
metformin
Glucovance 1.25mg/250mg,
2.5mg/500mg,
5mg/500mg
tabs 20mg/2000mg per day in single or divided doses
THIAZOLIDINEDIONE
pioglitazone Actos 15mg, 30mg, 45mg tabs 15−45mg once daily 45mg once daily
rosiglitazone Avandia 2mg, 4mg, 8mg tabs 4−8mg in single or 2 divided doses 8mg/day
THIAZOLIDINEDIONE + BIGUANIDE
pioglitazone/
metformin
ACTOplus met 15mg/500mg, 15mg/850mg tabs 45mg/2550mg per day in divided doses
ACTOplus met XR 15mg/1000mg, 30mg/1000mg ext‑rel tabs 45mg/2000mg per day
rosiglitazone/
metformin
Avandamet 2mg/500mg, 4mg/500mg, 2mg/1000mg, 4mg/1000mg tabs 8mg/2000mg per day in divided doses
THIAZOLIDINEDIONE + SULFONYLUREA
pioglitazone/
glimepiride
Duetact 30mg/2mg, 30mg/4mg tabs One 30mg/4mg tab once daily
rosiglitazone/
glimepiride
Avandaryl 4mg/1mg, 4mg/2mg, 4mg/4mg, 8mg/2mg, 8mg/4mg tabs 8mg/4mg per day
NOTES

Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. These products are intended for use as part of a total treatment regimen to maintain glycemic control that includes diet, regular exercise, blood glucose monitoring, and glycosylated hemoglobin monitoring. Patients should maintain regular caloric intake.

Adjust dose based on clinical effect. Start at a low dose and gradually titrate upwards according to clinical effect (especially in the elderly, malnourished, debilitated, or those who have renal and/or hepatic dysfunction).

(Rev. 5/2015)

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