Lupus Nephritis

Urinary Biomarker Index Measures LN Activity Without Biopsy

Urinary Biomarker Index Measures LN Activity Without Biopsy

The development of this scale, once further validated, will give clinicians the ability to verify lupus nephritis activity without the need for an invasive kidney biopsy.

SLE Renal Outcomes for Mixed LN vs Pure Proliferative LN

SLE Renal Outcomes for Mixed LN vs Pure Proliferative LN

Among the findings, researchers found no association between mixed or pure histopathologic features of LN at presentation and rates of complete or partial remission.

Lupus Nephritis ESRD Has Worse Outcomes

Lupus Nephritis ESRD Has Worse Outcomes

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Researchers find an increased risk of death among patients.

Acthar Gel May Be an Option for Nephrotic Syndrome

Acthar Gel May Be an Option for Nephrotic Syndrome

Athcar gel may be a treatment option for patients with treatment-resistant nephrotic syndrome.

Metabolic Syndrome Prevalent in Pre-Menopausal Women With Lupus

Metabolic Syndrome Prevalent in Pre-Menopausal Women With Lupus

Antimalarial protects against metabolic syndrome, countering steroid effects.

Vitamin D Doesn't Improve Interferon Response in Lupus Patients

Vitamin D Doesn't Improve Interferon Response in Lupus Patients

No change in interferon signature in vitamin D-deficient patients, those with vitamin D repletion.

<i>FCGR3B</i> Copy Number Loss Increases Lupus Nephritis Risk

<i>FCGR3B</i> Copy Number Loss Increases Lupus Nephritis Risk

Increased risk of systemic lupus erythematosus, lupus nephritis with copy number loss, not gain.

Proteinuria Levels Predict Long-Term Renal Outcomes in Lupus Nephritis

Proteinuria Levels Predict Long-Term Renal Outcomes in Lupus Nephritis

Urinary red blood cells undermine a composite prediction of renal outcome.

Mycophenolate Mofetil Offers No Advantage in Lupus Nephritis

Mycophenolate Mofetil Offers No Advantage in Lupus Nephritis

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New study also provides evidence that an early proteinuria decrease is a strong predictor of good long-term outcome.

Minorities, Uninsured Lack Care of ESRD in Lupus Nephritis

Minorities, Uninsured Lack Care of ESRD in Lupus Nephritis

Minority race/ethnicity and lack of private insurance associated with inadequate care in U.S.

Lupus Nephritis ESRD Rates Stable

Lupus Nephritis ESRD Rates Stable

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The risk of end-stage renal disease in patients with systemic lupus erythematosus may even be declining, but outcomes differ by race.

Over 100,000 Medicare Patients May Suffer from Glomerulonephritis

Over 100,000 Medicare Patients May Suffer from Glomerulonephritis

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The condition appears to be associated with high hospitalization and death rates, researchers reported.

Three Drug Combo Beneficial in Lupus Nephritis Patients

Three Drug Combo Beneficial in Lupus Nephritis Patients

Half of those lupus nephritis patients taking three medications achieved full remission.

Potential Plant-Derived Lupus Nephritis Treatment Has Few Side Effects

Potential Plant-Derived Lupus Nephritis Treatment Has Few Side Effects

A plant-based compound could provide a new treatment for lupus nephritis with fewer side effects.

Mortality in Lupus Patients Does Not Differ By Dialysis Type

Mortality in Lupus Patients Does Not Differ By Dialysis Type

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Large study looked at matched pairs of lupus patients with renal disease starting dialysis with hemodialysis or peritoneal dialysis.

Kidney Disease Significantly Reduces Life Expectancy in SLE

Kidney Disease Significantly Reduces Life Expectancy in SLE

With systemic lupus erythematosus, kidney disease reduces life expectancy an average of 15 years

Kidney Involvement, High Anti-dsDNA Predict Lupus Flares

Kidney Involvement, High Anti-dsDNA Predict Lupus Flares

Predictors of moderate-severe SLE flare at week 52 identified using three indicators

Proteinuria Decline Linked to Improved Lupus Nephritis Outcomes

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A 50% or greater reduction in proteinuria after six months of treatment for severe lupus nephritis predicted better 15-year renal survival.

Do you think patients with lupus nephritis can be good renal transplant candidates if their disease has been quiescent for at least one year?

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In a recent study researchers examined transplant outcomes in patients with lupus nephritis who had no clinical evidence of disease in the year prior.

Lupus Nephritis Need Not Prevent Renal Transplants

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Lupus nephritis patients can be good candidates if their disease is quiescent for at least one year prior to surgery.

A Clue to Black Lupus Patients' Higher Risk for ESRD

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Genetic changes may partly explain why African-Americans with lupus are up to five times more likely develop end-stage kidney disease.

Systemic Lupus Erythematosus Flares Occur Despite Dialysis

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SLE patients with renal failure often continue to experience flares, but most commonly these are serologic rather than clinical.

Abnormal SLE Serology Need Not Bar Pregnancy

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If a lupus patient has never had renal disease, pregnancy, in and of itself, is not likely to increase that risk.

Proteinuria Recovery Heads Off LN Comorbidities

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Even partial recovery in lupus nephritis patients lowers the risk of needing dialysis or a kidney transplant.

Lupus Nephritis Patient Genotype May Not Predict MMF Response

Lupus Nephritis Patient Genotype May Not Predict MMF Response

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Effects of MMF may be influenced by the pathogenesis and/or cellular micro-environments unique to each disease process.

An Update on the Management of Lupus Nephritis

Approximately 30%-50% of SLE patients have clinically evident renal disease at ­presentation, but renal involvement occurs in up to 60% of patients overall.

New Lupus Nephritis Guidelines Issued

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The American College of Rheumatology (ACR) has issued new guidelines for screening, treating, and managing lupus nephritis (LN), including methods of identifying kidney disease, newer therapies, and pregnant patient care.

Rituximab Ineffective as Lupus Nephritis Add-On Therapy

Rituximab Ineffective as Lupus Nephritis Add-On Therapy

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Adding rituximab to mycophenolate mofetil and corticosteroids does not improve outcomes in patients with lupus nephritis (LN), according to a study.

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