Lupus Nephritis

Potential Plant-Derived Lupus Nephritis Treatment Has Few Side Effects

Potential Plant-Derived Lupus Nephritis Treatment Has Few Side Effects

A plant-based compound could provide a new treatment for lupus nephritis with fewer side effects.

Mortality in Lupus Patients Does Not Differ By Dialysis Type

Mortality in Lupus Patients Does Not Differ By Dialysis Type

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Large study looked at matched pairs of lupus patients with renal disease starting dialysis with hemodialysis or peritoneal dialysis.

Kidney Disease Significantly Reduces Life Expectancy in SLE

Kidney Disease Significantly Reduces Life Expectancy in SLE

With systemic lupus erythematosus, kidney disease reduces life expectancy an average of 15 years

Kidney Involvement, High Anti-dsDNA Predict Lupus Flares

Kidney Involvement, High Anti-dsDNA Predict Lupus Flares

Predictors of moderate-severe SLE flare at week 52 identified using three indicators

Proteinuria Decline Linked to Improved Lupus Nephritis Outcomes

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A 50% or greater reduction in proteinuria after six months of treatment for severe lupus nephritis predicted better 15-year renal survival.

Do you think patients with lupus nephritis can be good renal transplant candidates if their disease has been quiescent for at least one year?

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In a recent study researchers examined transplant outcomes in patients with lupus nephritis who had no clinical evidence of disease in the year prior.

Lupus Nephritis Need Not Prevent Renal Transplants

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Lupus nephritis patients can be good candidates if their disease is quiescent for at least one year prior to surgery.

A Clue to Black Lupus Patients' Higher Risk for ESRD

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Genetic changes may partly explain why African-Americans with lupus are up to five times more likely develop end-stage kidney disease.

Systemic Lupus Erythematosus Flares Occur Despite Dialysis

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SLE patients with renal failure often continue to experience flares, but most commonly these are serologic rather than clinical.

Abnormal SLE Serology Need Not Bar Pregnancy

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If a lupus patient has never had renal disease, pregnancy, in and of itself, is not likely to increase that risk.

Proteinuria Recovery Heads Off LN Comorbidities

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Even partial recovery in lupus nephritis patients lowers the risk of needing dialysis or a kidney transplant.

Lupus Nephritis Patient Genotype May Not Predict MMF Response

Lupus Nephritis Patient Genotype May Not Predict MMF Response

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Effects of MMF may be influenced by the pathogenesis and/or cellular micro-environments unique to each disease process.

An Update on the Management of Lupus Nephritis

Approximately 30%-50% of SLE patients have clinically evident renal disease at ­presentation, but renal involvement occurs in up to 60% of patients overall.

New Lupus Nephritis Guidelines Issued

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The American College of Rheumatology (ACR) has issued new guidelines for screening, treating, and managing lupus nephritis (LN), including methods of identifying kidney disease, newer therapies, and pregnant patient care.

Rituximab Ineffective as Lupus Nephritis Add-On Therapy

Rituximab Ineffective as Lupus Nephritis Add-On Therapy

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Adding rituximab to mycophenolate mofetil and corticosteroids does not improve outcomes in patients with lupus nephritis (LN), according to a study.

Black Race Worsens Transplant Outcomes

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Black race is associated with worse renal transplant outcomes among patients with lupus nephritis and focal segmental glomerulosclerosis (FSGS), according to two studies presented at Kidney Week, the annual meeting of the American Society of Nephrology.

MMF Found Superior for Lupus Nephritis

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Mycophenolate mofetil (MMF) is more effective than azathioprine as maintenance therapy for patients with active lupus nephritis (LN) who responded to induction therapy, researchers reported.

Abatacept May Benefit Some Lupus Nephritis Patients

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CHICAGO—Adding abatacept to mycophenolate mofetil (MMF) and steroids does not significantly improve the time to complete renal response in patients with lupus nephritis (LN), according to the findings of a 12-month study presented at the 2011 American College of Rheumatology annual meeting.

Vascular Biomarkers May Help Predict Lupus Nephritis Flares

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CHICAGO—Vascular biomarkers may forecast impending flare or flare outcome in patients with lupus nephritis (LN), according to researchers in New York.

Biopsies May Predict Renal Outcomes in Patients with Lupus Nephritis

Biopsies May Predict Renal Outcomes in Patients with Lupus Nephritis

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CHICAGO—Certain features at the time of renal biopsy are associated with a particular class of lupus nephritis (LN) and may independently predict good renal outcomes, according to a new Canadian study presented at the 2011 American College of Rheumatology Annual Scientific Meeting.

Prolonged Immunoadsorption Eases Lupus Nephritis

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ATLANTA—Prolonged immunoadsorption (IAS) decreases proteinuria and leads to sustained stabilization of lupus nephritis in patients with highly active systemic lupus erythematosus (SLE), according to long-term results of a small Austrian study. The treatment did not result in tumors, anaphylaxis, or orthostatic events.

Big Drop in Lupus Nephritis Deaths Documented

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ATLANTA—Mortality rates from lupus nephritis have decreased significantly since 1975 but have leveled off over the past 10 years, British researchers found.

Earlier Rituximab Better for Lupus Nephritis Patients

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ATLANTA—Lupus nephritis patients who receive rituximab earlier in the course of their disease rather than later have better outcomes, new findings suggest.

Regimen May Improve Lupus Nephritis Care

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ATLANTA—Enteric-coated mycophenolate sodium (EC-MPS) in combination with steroids is a viable therapy for lupus nephritis, according to an Italian study presented at the American College of Rheumatology annual meeting.

Low-Dose Combination May Be Effective for Refractory Lupus Nephritis

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ATLANTA—A low-dose combination of mycophenolate mofetil (MMF) and tacrolimus (TAC) may be a viable option for treating refractory lupus nephritis, according to a new study by Chinese investigators.

Kidney Transplants Generally Safe for Lupus Patients

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Contrary to previous studies, lupus patients who receive kidney transplants rarely develop lupus nephritis in their new allograft, according to a study presented at ASN's Renal Week conference.

Rituximab Eases Lupus Nephritis

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Rituximab is an effective treatment for lupus nephritis that enables reductions in maintenance steroids, data show.

Fatal Infections Probed in Pediatric LN Patients

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Prior history of treatment with pulse methylprednisolone may increase the risk of fatal infection in pediatric lupus nephritis (LN) patients treated with IV cyclophosphamide (IVCY), researchers reported.

Active Lupus Nephritis Raises Pregnancy Risks

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Pregnant patients with active lupus nephritis have a higher incidence of maternal and fetal complications compared with patients who have systemic lupus erythematosus (SLE) without renal involvement, researchers reported in Lupus (2009;18:342-347).

In SLE, Renal Damage Is No. 1 Death Predictor

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SAN FRANCISCO—Preventing renal damage in patients with systemic lupus erythematosus (SLE) may be critical to lowering their mortality rate, according to a new report.

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