Lupus Nephritis

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New Lupus Nephritis Guidelines Issued

Stephan Cho May 03, 2012

The American College of Rheumatology (ACR) has issued new guidelines for screening, treating, and managing lupus nephritis (LN), including methods of identifying kidney disease, newer therapies, and pregnant patient care.

Rituximab Ineffective as Lupus Nephritis Add-On Therapy

Rosemary Frei, MSc January 18, 2012

Adding rituximab to mycophenolate mofetil and corticosteroids does not improve outcomes in patients with lupus nephritis (LN), according to a study.

MMF Found Superior for Lupus Nephritis

Jody A. Charnow November 28, 2011

Mycophenolate mofetil (MMF) is more effective than azathioprine as maintenance therapy for patients with active lupus nephritis (LN) who responded to induction therapy, researchers reported.

Abatacept May Benefit Some Lupus Nephritis Patients

John Schieszer November 14, 2011

CHICAGO—Adding abatacept to mycophenolate mofetil (MMF) and steroids does not significantly improve the time to complete renal response in patients with lupus nephritis (LN), according to the findings of a 12-month study presented at the 2011 American College of Rheumatology annual meeting.

Vascular Biomarkers May Help Predict Lupus Nephritis Flares

John Schieszer November 14, 2011

CHICAGO—Vascular biomarkers may forecast impending flare or flare outcome in patients with lupus nephritis (LN), according to researchers in New York.

Biopsies May Predict Renal Outcomes in Patients with Lupus Nephritis

John Schieszer November 09, 2011

CHICAGO—Certain features at the time of renal biopsy are associated with a particular class of lupus nephritis (LN) and may independently predict good renal outcomes, according to a new Canadian study presented at the 2011 American College of Rheumatology Annual Scientific Meeting.

Prolonged Immunoadsorption Eases Lupus Nephritis

John Schieszer April 21, 2011

ATLANTA—Prolonged immunoadsorption (IAS) decreases proteinuria and leads to sustained stabilization of lupus nephritis in patients with highly active systemic lupus erythematosus (SLE), according to long-term results of a small Austrian study. The treatment did not result in tumors, anaphylaxis, or orthostatic events.

Big Drop in Lupus Nephritis Deaths Documented

Jody A. Charnow February 24, 2011

ATLANTA—Mortality rates from lupus nephritis have decreased significantly since 1975 but have leveled off over the past 10 years, British researchers found.

Earlier Rituximab Better for Lupus Nephritis Patients

John Schieszer February 24, 2011

ATLANTA—Lupus nephritis patients who receive rituximab earlier in the course of their disease rather than later have better outcomes, new findings suggest.

Regimen May Improve Lupus Nephritis Care

John Schieszer February 07, 2011

ATLANTA—Enteric-coated mycophenolate sodium (EC-MPS) in combination with steroids is a viable therapy for lupus nephritis, according to an Italian study presented at the American College of Rheumatology annual meeting.

Low-Dose Combination May Be Effective for Refractory Lupus Nephritis

John Schieszer February 07, 2011

ATLANTA—A low-dose combination of mycophenolate mofetil (MMF) and tacrolimus (TAC) may be a viable option for treating refractory lupus nephritis, according to a new study by Chinese investigators.

Kidney Transplants Generally Safe for Lupus Patients

John Schieszer October 31, 2009

Contrary to previous studies, lupus patients who receive kidney transplants rarely develop lupus nephritis in their new allograft, according to a study presented at ASN's Renal Week conference.

Rituximab Eases Lupus Nephritis

Jody A. Charnow September 21, 2009

Rituximab is an effective treatment for lupus nephritis that enables reductions in maintenance steroids, data show.

Fatal Infections Probed in Pediatric LN Patients

Jody A. Charnow May 07, 2009

Prior history of treatment with pulse methylprednisolone may increase the risk of fatal infection in pediatric lupus nephritis (LN) patients treated with IV cyclophosphamide (IVCY), researchers reported.

Active Lupus Nephritis Raises Pregnancy Risks

Jody A. Charnow March 23, 2009

Pregnant patients with active lupus nephritis have a higher incidence of maternal and fetal complications compared with patients who have systemic lupus erythematosus (SLE) without renal involvement, researchers reported in Lupus (2009;18:342-347).

In SLE, Renal Damage Is No. 1 Death Predictor

John Schieszer January 16, 2009

SAN FRANCISCO—Preventing renal damage in patients with systemic lupus erythematosus (SLE) may be critical to lowering their mortality rate, according to a new report.

Drugs Comparable for Adolescent Lupus Nephritis

John Schieszer December 29, 2008

SAN FRANCISCO—Lupus nephritis (LN) in adolescents responds similarly to mycophenolate mofetil (MMF) and IV cyclophosphamide, according to data reported at the American College of Rheumatology (ACR) annual meeting here.

Renal Flares Can Hike Medical Costs

John Schieszer December 10, 2008

SAN FRANCISCO—Patients with lupus nephritis (LN) who experience renal flares incur nearly double the direct medical costs over one year compared with those who not have flares, data suggest.

Incidence of Lupus-Nephritis-Related ESRD Highest in Blacks

John Schieszer December 08, 2008

SAN FRANCISCO—The incidence of end-stage renal disease (ESRD) due to lupus nephritis (LN) rose significantly in the United States from 1995 to 2004, according to new study data presented here at the American College of Rheumatology annual meeting. The incidence was significantly higher among African Americans and women.

Lupus Nephritis Recurrence After Renal Transplant

John Schieszer December 08, 2008

SAN FRANCISCO—Lupus nephritis recurrence (LNR) in renal transplant recipients with systemic lupus erythematosus (SLE) does not have an adverse impact on allograft or patient survival rates, according to the largest analysis of its kind to be reported.

Comparison Between Tacrolimus (TAC) and Mycophenolate Mofetil (MMF) for Induction of Remission in Lupus Nephritis

Phase 2 Study of Human Umbilical Cord Derived Mesenchymal Stem Cell for the Treatment of Lupus Nephritis (hUC-MSC-SLE)

Safety Study of Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody in Lupus Nephritis

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