Proteinuric Remission in Lupus Nephritis Predicts Better Outcomes
American College of Physicians guidelines addresses nonsurgical management of urinary incontinence.
Remission of proteinuria in patients with diffuse proliferative lupus nephritis (LN) is associated with a good prognosis, South Korean researchers reported online ahead of print in Lupus.
A team led by Ho Jun Chin, MD, of Seoul National University Bundang Hospital studied 26 men and 167 women with biopsy-confirmed diffuse proliferative LN. Patients had a mean age of 31.2 years at renal biopsy. During follow-up, 82 (42.5%) patients experienced proteinuric remission and 111 did not. Results showed that patients who achieved proteinuric remission had a decreased risk of death, incidence end-stage renal disease (ESRD), and a composite outcome compared with those who did not have remission.
During a mean follow-up of 157.9 months, among patients who achieved proteinuric remission, 1 (1.2%) died, 1 (1.2%) progressed to ESRD, and 2 (2.4%) had composite outcomes. Among patients without remission, 9 (8.1%) died, 24 (21.6%) progressed to ESRD, and 30 (27%) had composite outcomes.