Low Testosterone Associated with Increased Dementia Risk

Share this article:

Low levels of total and bioavailable testosterone may be associated with an increased risk of dementia in elderly men, according to French investigators.

From a cohort of 3,650 men aged 65 years and older, Laure Carcaillon, MD, of Inserm in Villejuif, France, and collaborators compared 105 men with incident dementia and a random sample of 413 men without dementia. The median follow-up period was 3.1 years. Compared with the middle tertile of total testosterone (total-T) level, the lower and upper tertiles were associated with a 2.3 times and 1.9 times increased risk of dementia, respectively. Low bioavailable testosterone (bio-T) also was associated with a greater risk for dementia, especially among men aged 80 years and older, investigators reported online ahead of print in Alzheimer's & Dementia. In men aged 80 and older, low bio-T was associated with a significant threefold increased risk of dementia; in men younger than 80, it was associated with a nonsignificant 7% increased risk.

Additionally, the risk of dementia associated with low bio-T was greater in men with a high level of education compared with men who had a low level of education.

Taken together, the authors noted, their results support the hypothesis of a deleterious effect of low testosterone concentrations on brain aging, and also suggest that high levels of total-T could increase this risk.

Share this article:
You must be a registered member of RUN to post a comment.
close

Next Article in Hypogonadism

More in Hypogonadism

Testosterone Supplements Not Linked to Heart Attacks

Testosterone Supplements Not Linked to Heart Attacks

Finding runs counter to some prior reports; much larger trials are needed, experts say.

Topical Testosterone Gel Approved

Topical Testosterone Gel Approved

In a study, 74% of men treated with Vogelxo achieved normal testosterone levels within 90 days.

FDA Clears First Nasal Testosterone Therapy

FDA Clears First Nasal Testosterone Therapy

The product is self-administered via a nasal applicator.