Low-Dose Valacyclovir Effective for CMV Prophylaxis

Share this article:

Low-dose valacyclovir prophylaxis reduces the incidence of cytomegalovirus (CMV) disease in CMV-negative renal transplant recipients who receive a renal allograft from a CMV-infected donor, new findings suggest. It also results in high patient and graft survival rates.

The researchers, led by Fredrik Sund, MD, PhD, of Uppsala University in Uppsala, Sweden, noted that 8 g/day of valacyclovir has been used as prophylaxis, but neurotoxic adverse effects have limited the use of this regimen. The aim of their study was to evaluate a valacyclovir prophylactic regimen of 3 g/day for 90 days after transplantation in 102 CMV-negative recipients who received a donor from a CMV-positive donor.

CMV disease was diagnosed in 25% of patients, and 2% experienced tissue-invasive CMV disease, Dr. Sund's group reported online in Nephrology Dialysis Transplantation. The rejection frequency was 22% and neurotoxic adverse effects were observed in 2% of patients. The five-year patient and graft survival rates were approximately 90% and 80%, respectively. These rates are comparable to those observed among 3,904 European kidney transplant recipients (excluding those in the Uppsala cohort) enrolled in the large international Collaborative Transplant Study.

Share this article:
You must be a registered member of RUN to post a comment.
close

Next Article in Transplantation

More in Transplantation

Kidney Transplants Less Likely in Overweight, Obese Women

Kidney Transplants Less Likely in Overweight, Obese Women

The odds of receiving a kidney decreased with increasing body mass index.

Sirolimus Reduces Post-Transplant HIV Levels

Sirolimus Reduces Post-Transplant HIV Levels

Lower post-transplant HIV DNA levels associated with sirolimus use.

Kidney Remaining After Donor Nephrectomy Increases in Size

Kidney Remaining After Donor Nephrectomy Increases in Size

Increment in renal parenchymal volume occurs within days after a kidney is removed from a living donor.