Kidney Week 2017

Phosphate Binder Use Tied With Better Survival

Phosphate Binder Use Tied With Better Survival

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Phosphate binder use is associated with a 25% and 37% decreased risk of death from infection-related causes and all-causes, respectively, compared with non-users.

Reducing Phosphorus Improves Survival

Reducing Phosphorus Improves Survival

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Achieving a phosphate value of 1.4 mmol/L seemed optimal.

IV Iron, Erythropoietin Equally Effective for Anemia in HD Patients

IV Iron, Erythropoietin Equally Effective for Anemia in HD Patients

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Intravenous iron and erythropoietin produced a similar hemoglobin response among hemodialysis patients with moderate anemia.

Acute Kidney Injury After Cardiac Revascularization on the Rise

Acute Kidney Injury After Cardiac Revascularization on the Rise

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From 2004 to 2012, the incidence of AKI increased from 4.9% to 14.2% among CABG patients and from 2.7% to 8.8% among PCI patients.

Predialysis Anemia Treatment May Cut Mortality After HD Initiation

Predialysis Anemia Treatment May Cut Mortality After HD Initiation

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HD patients with untreated or ineffectively treated anemia prior to dialysis initiation were more likely to die than those who had consistently well-treated anemia.

AKI More Likely After Intracoronary Versus IV Contrast Delivery

AKI More Likely After Intracoronary Versus IV Contrast Delivery

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In a phase 3 trial, acute kidney injury developed in 13.2% of patients undergoing invasive coronary angiography compared with 5.6% of those undergoing computed tomography angiography.

Tolvaptan Slows Renal Function Decline in Later-Stage ADPKD

Tolvaptan Slows Renal Function Decline in Later-Stage ADPKD

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Patients with autosomal dominant polycystic kidney disease treated with tolvaptan experienced a 35% decrease in the annual rate of decline in eGFR.

Causes of Most Kidney Transplant Patient Deaths Reported as Unknown

Causes of Most Kidney Transplant Patient Deaths Reported as Unknown

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Among kidney transplant recipients who died with a functioning graft, the cause of death was reported as unknown for 64% of them.

Low Uric Acid Ups Death Risk in Hemodialysis Patients

Low Uric Acid Ups Death Risk in Hemodialysis Patients

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The 5-year survival rates was 80.7% for patients in the lowest quartile of serum uric acid at HD initiation versus 89.6% for those in the highest quartile.

Higher Relative Urine Supersaturations Up Stone Risk

Higher Relative Urine Supersaturations Up Stone Risk

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Likelihood of stone formation increases with higher calcium oxalate and calcium phosphate relative supersaturation.

Abnormal Sodium Levels Up Bacteremia Risk in Dialysis Patients

Abnormal Sodium Levels Up Bacteremia Risk in Dialysis Patients

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Study reveals 2-fold higher incidence of bacteremia among dialysis patients with low and high serum sodium levels.

Etelcalcetide Injection Into Parathyroid Glands Safe

Etelcalcetide Injection Into Parathyroid Glands Safe

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In a pilot study, investigators observed no harmful effects from etelcalcetide injection, and 5 of 10 of patients had a greater than 50% decline in PTH levels.

Waist-to-hip Ratio Predicts CV Mortality in Hemodialysis Patients

Waist-to-hip Ratio Predicts CV Mortality in Hemodialysis Patients

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Each 0.1 increase in WHR is associated with a 1.7-fold increased risk of cardiovascular death.

Phosphate Binder Reduces FGF23 in CKD Patients

Phosphate Binder Reduces FGF23 in CKD Patients

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Patients with non-dialysis chronic kidney disease and iron deficiency anemia treated with ferric citrate experienced significant declines in FGF23 regardless of change in serum phosphorus.

Rapid Correction of Inpatient Hyponatremia Can Occur Frequently

Rapid Correction of Inpatient Hyponatremia Can Occur Frequently

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Study documents occurrence of rapid correction in 44.3% of hospitalized patients.

Paricalcitol May Be More Efficacious Than Cinacalcet in HD

Paricalcitol May Be More Efficacious Than Cinacalcet in HD

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Therapy with paricalcitol alone achieved the greatest decline in intact parathyroid hormone among hemodialysis with secondary hyperparathyroidism.

Veterans With PTSD Less Likely to Die After Starting Dialysis

Veterans With PTSD Less Likely to Die After Starting Dialysis

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Patients with post-traumatic stress disorder had an 11% lower death risk 1 year after initiating dialysis than those without the disorder, study finds.

'Clinically Negligible' Residual Kidney Function Still Beneficial

'Clinically Negligible' Residual Kidney Function Still Beneficial

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Even at very low levels, residual kidney function in hemodialysis patients clears uremic solutes.

Rapid Kidney Function Decline in Blacks Linked to Elevated Uric Acid

Rapid Kidney Function Decline in Blacks Linked to Elevated Uric Acid

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Each 1 standard deviation in baseline uric acid levels was associated with a significant 80% increased odds of rapid kidney function decline.

Low Urinary Uromodulin Predicts Worse Kidney Outcomes

Low Urinary Uromodulin Predicts Worse Kidney Outcomes

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Patients in the lowest quartiles of urinary uromodulin had increased risks of end-stage renal disease and rapid kidney function decline.

Anemia Raises ESRD Risk in Patients With Chronic Kidney Disease

Anemia Raises ESRD Risk in Patients With Chronic Kidney Disease

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In a study, end-stage renal disease was 31% more likely to develop in CKD patients with versus without anemia.

Hypertension, Diabetes at Hemodialysis Initiation Increasing

Hypertension, Diabetes at Hemodialysis Initiation Increasing

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From 1995 to 2015, the prevalence of hypertension and diabetes among patients starting hemodialysis increased from 67.9% to 87.6% and from 43.1% to 59.6%, respectively.

ESRD Frequently Follows Dialysis-Dependent AKI

ESRD Frequently Follows Dialysis-Dependent AKI

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In a study, end-stage renal disease developed in 56% of patients discharged from a hospital with acute kidney injury requiring dialysis.

Biomarkers Predict Renal Function Decline, CV Events

Biomarkers Predict Renal Function Decline, CV Events

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High levels of parathyroid hormone and fibroblast growth factor 23 in CKD patients are associated with need for renal replacement therapy or a 50% or greater decline in eGFR.

Intensive Home HD, Deceased-Donor Transplants Offer Similar Survival

Intensive Home HD, Deceased-Donor Transplants Offer Similar Survival

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After adjusting for confounders, patients on intensive home hemodialysis and recipients of deceased-donor kidneys showed no significant difference in death risk

Anemia Linked to High FGF23 Levels in CKD Patients

Anemia Linked to High FGF23 Levels in CKD Patients

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CKD patients in the 3rd and 4th quartiles of c-terminal serum fibroblast growth factor 23 had a 74% and 73% higher risk for anemia compared with those in the 1st quartile.

AKI at 12 and 24 Hours After PCI Independently Ups Death Risk

AKI at 12 and 24 Hours After PCI Independently Ups Death Risk

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Timing of AKI after urgent percutaneous coronary intervention affects risk of significant kidney function loss 1 year after the procedure.

Post-Dialysis Survival Odds Better After CABG vs PCI

Post-Dialysis Survival Odds Better After CABG vs PCI

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US veterans who underwent coronary artery bypass grafting versus percutaneous coronary intervention prior to starting dialysis had a 28% lower risk of death.

Anemia Risk Factors in Diabetic Nephropathy Patients Identified

Anemia Risk Factors in Diabetic Nephropathy Patients Identified

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Proteinuria and renin-angiotensin-aldosterone system inhibitors are independently associated with a significant 6-fold increased odds for anemia in patients with diabetic nephropathy.

No iPTH Oversuppression With Extended-Release Calcifediol

No iPTH Oversuppression With Extended-Release Calcifediol

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Intact parathyroid hormone levels decline in proportion with SHPT severity in patients taking the drug.

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