Low Uric Acid Ups Death Risk in Hemodialysis Patients
The 5-year survival rates was 80.7% for patients in the lowest quartile of serum uric acid at HD initiation versus 89.6% for those in the highest quartile.
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NEW ORLEANS—Low serum uric acid (SUA) levels at the start of hemodialysis (HD) are associated with increased mortality risk, Japanese investigators reported at the American Society of Nephrology's Kidney Week 2017 meeting.
In a study of 462 patients who underwent HD over a 12-year period (2004 to 2016), researchers found that patients in the lowest quartile of SUA (less than 6.2 mg/dL) at HD initiation had significantly lower cumulative 3-year and 5-year survival rates than those in the highest quartile (8.4 mg/dL or higher): 81.4% vs 93.4% and 80.7% vs 89.6%, respectively. Patients with an SUA level below 5 mg/dL had a significant 8.4 times increased risk of death compared with patients who had higher levels. The study, by Yoshiko Nishizawa, MD, of Ichiyokai Harada Hospital in Hiroshima, and colleagues, also demonstrated a link between low SUA level and malnutrition status as reflected by associations with the geriatric nutritional risk index and normalized protein catabolic rate.
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Nishizawa Y, Mizuiri S, Asai M, et al. Low serum uric acid-mortality association in incident hemodialysis patients. Presented in poster format at Kidney Week 2017 in New Orleans (Oct. 31 to Nov. 5). Abstract FR-PO863.