Kidney Graft Loss Risk Not Associated With Vitamin D Deficiency

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In a study 383 kidney transplant recipients, low levels of 25-hydroxyvitamin D were not associated with an increased risk of graft loss following transplantation.
In a study 383 kidney transplant recipients, low levels of 25-hydroxyvitamin D were not associated with an increased risk of graft loss following transplantation.
The following article is part of conference coverage from Kidney Week 2017 in New Orleans hosted by the American Society of Nephrology. Renal & Urology News staff will be reporting live on medical studies conducted by nephrologists and other specialists who are tops in their field in acute kidney injury, chronic kidney disease, dialysis, transplantation, and more. Check back for the latest news from Kidney Week 2017.

NEW ORLEANS—Kidney transplant recipients with low 25-hydroxyvitamin D (25-OHD) levels are at no greater risk for allograft function decline, according to a new study presented at the American Society of Nephrology's Kidney Week 2017.

Puneet Bedi, MD, and colleagues from Montefiore Medical Center in Bronx, New York, measured 25-OHD levels and intact-parathyroid hormone (iPTH) levels after kidney transplantation in 383 patients.

At 6 months after transplantation, 29.2% and 22.2% of patients had 25-OHD levels below 15 and 15 to 19.9 ng/mL, respectively. At 1 year, the proportions were 14.9% and 21.9%, respectively, and at 3 years 16.8% and 18.5%. When patients were stratified by vitamin D status, the groups appeared similar in age, sex, race, type of transplant, donor age, donor final creatinine, kidney donor profile index (KDPI) score, panel reactive antibody, pre-transplant donor-specific antibodies, and type of induction therapy. Higher iPTH levels correlated with lower 25-OHD values at 6 months.

Lower 25-OHD levels were not associated with an increased risk for graft loss. Other outcomes were similar as well regardless of vitamin D status over 3 years of follow-up, including patient survival, acute antibody or T-cell mediated rejection, transplant glomerulopathy, de novo donor-specific antibodies, opportunistic viral (cytomegalovirus and BK virus) and fungal infections, malignancy, proteinuria, and serum creatinine levels.

“Vitamin D deficiency after kidney transplantation is common. However, our single center retrospective study did not demonstrate any association between low vitamin D levels and any clinical outcomes after kidney transplantation including acute and chronic rejection, allograft function, proteinuria, opportunistic infections and malignancy,” co-investigator Enver Akalin, MD, told Renal & Urology News. “To reach more meaningful conclusions, multicenter and prospective trials are required.”

Visit Renal & Urology News' conference section for continuous coverage from Kidney Week 2017.

Reference

Bedi P, Hayde NA, Ajaimy M, Akalin E. Prevalence of vitamin D deficiency after kidney transplantation and its association with clinical outcomes . Presented in poster format at Kidney Week 2017 in New Orleans (Oct. 31-Nov. 5). Poster TH-PO925.

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