ESRD Linked to Recurrent Symptomatic Kidney Stones
Recurrent, but not first-time, symptomatic kidney stone formers are at elevated risk for end-stage renal disease and death.
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NEW ORLEANS—Patients who suffer from recurrent symptomatic kidney stones are at elevated risk for end-stage renal disease (ESRD) and death, investigators reported at the American Society of Nephrology's Kidney Week 2017 meeting. The first symptomatic kidney stone does not increase the risk of these outcomes.
Tsering Dhondup, MD, and collaborators at Mayo Clinic in Rochester, Minnesota, compared 7008 stone formers (SFs) and 27,149 age and sex matched controls. Over a mean follow-up of 9.4 years, ESRD developed in 68 and 110 SFs and controls, respectively, and 1110 and 3839 deaths occurred in these groups, respectively.
Compared with controls, recurrent SFs had a significant 3.3 times and 1.2 times increased risk of ESRD and death, respectively. First-time symptomatic SFs had a non-significant 1.4 and 1.05 times increased risk of ESRD and death, respectively.
“The risk of ESRD and mortality may be higher in recurrent than incident symptomatic SFs due to more substantial renal injury from more severe stone disease,” the investigators concluded. “Thus efforts to reduce kidney stone recurrence may have beneficial impact on ESRD and mortality risk.” Asymptomatic SFs also had a significant 3.8 and 1.4 times increased risk of ESRD and death, respectively.
The author's hypothesized that patients who undergo abdominal imaging will be more likely to have incidentally discovered asymptomatic stones, but it is other medical conditions that lead to ESRD or death
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Dhondup T, Kittanamongkolchai W, Mehta RA, et al. Recurrent but not first time symptomatic kidney stone formers are at higher risk for ESRD and death. Data presented in poster format at Kidney Week 2017 in New Orleans (Oct. 31 to Nov. 5). Abstract TH-PO1082.