Anemia Raises ESRD Risk in Patients With Chronic Kidney Disease
In a study, end-stage renal disease was 31% more likely to develop in CKD patients with versus without anemia.
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NEW ORLEANS—Anemia is independently associated with an increased risk for end-stage renal disease (ESRD) among patients with chronic kidney disease (CKD), investigators reported at the American Society of Nephrology's Kidney Week 2017 meeting.
The finding is based on a study of 3919 patients with CKD, of whom 1859 (47.4%) had anemia at study entry. Over a median follow-up of 7.8 years, ESRD developed in 1010 patients and 994 patients died. In a fully adjusted model, patients with anemia had a significant 31% higher risk of ESRD compared with patients who did not have anemia. Each 1 gram decrease in hemoglobin was associated with a significant 10% increase in ESRD risk. Anemia was not significantly associated with mortality, according to the investigators.
The researchers defined anemia according to World Health Organization criteria (hemoglobin level less than 12 g/dL in women and less than 13 g/dL in men).
The study population had a mean age of 58 years, and 45% of patients were female. The racial composition was 42% white, 42% black, and 13% Hispanic. The mean estimated glomerular filtration rate (eGFR) was 45 mL/min/1.73 m2 and the median proteinuria value was 0.19 g per 24 hours. Compared with patients who did not have anemia, those with anemia were older and more likely to be black or Hispanic. They also were more likely to have a lower mean eGFR and higher proteinuria values.
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Saraf S, Ricardo AC, Lash JP, et al. Anemia is a risk factor for incident ESRD. Presented in poster format at Kidney Week 2017 in New Orleans (Oct. 31-Nov. 5). Poster FR-PO391.