Prescribed Meds May Up Phosphate Burden in Hemodialysis Patients

Study implicates amlodipine, lisinopril, clonidine, acetaminophen, and omeprazole.
Study implicates amlodipine, lisinopril, clonidine, acetaminophen, and omeprazole.

CHICAGO—Medications commonly prescribed for in-center hemodialysis (HD) patients may add to their overall daily phosphate load, investigators concluded in a poster presentation at the American Society of Nephrology's 2016 Kidney Week meeting.

Dixie-Ann Sawin, PhD, and colleagues at Fresenius Medical Care North America (FMCNA), based in Waltham, Massachusetts, reviewed 695,759 prescriptions for FMCNA in-center HD patients and found that the top 5 prescribed drug classes were calcium-channel blockers (22%), proton pump inhibitors (PPIs, 18%), acetaminophen-opioid (13%), ACE inhibitors (10%), and alpha-2 agonists (9%). The top 5 medication orders were amlodipine, lisinopril, clonidine, acetaminophen-opioid, and omeprazole. On average, the addition phosphate added to patients' daily intake was 36.2 mg for amlodipine, 75–148.8 mg for lisinopril, 2.9–7.2 mg for clonidine, 0 mg for acetaminophen-opioid, and 204.8–234 mg for omeprazole per day.

The investigators concluded that increased phosphate content in medications prescribed to in-center HD patients may contribute to their overall daily phosphate load, requiring more phosphate binders and thus increasing daily pill burden and affecting medication adherence.

Click here for more coverage from the American Society of Nephrology's Kidney Week 2016 in Chicago.

Reference

  1. Sawin DA et al. Increased phosphate burden from medications prescribed to in-center hemodialysis patients. Poster presented at the 2016 Kidney Week meeting in Chicago, Nov. 15-20.
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