Early RRT for AKI May Lower Risk of Dialysis Dependence
It also may shorten intensive care unit and hospital length of stay versus late RRT in critically ill patients, meta-analysis reveals.
CHICAGO—Early initiation of renal replacement therapy (RRT) for acute kidney injury (AKI) in critically ill patients may decrease dependence on long-term dialysis, investigators reported at the American Society of Nephrology's 2016 Kidney Week meeting.
A systematic review and meta-analysis of 9 randomized controlled trials that included a total of 1599 critically ill patients showed that early RRT was associated with a significant 45% decreased risk of becoming dialysis dependent compared with late RRT, Rhea Bhargava, MD, of the University of Missouri-Kansas City School of Medicine, and colleagues concluded. Patients who had early RRT had a shorter stay (by a mean of 1.41 days) in the intensive care unit compared with patients who had late RRT and a short hospital length of stay (by a mean of 5.1 days). The investigators found no significant difference in mortality or adverse between the groups.
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- Bhargava R, Narsingam S, Grewal H, et al. Timing of renal replacement therapy in acute kidney injury: A systemic review and meta-analysis. Poster presented at the 2016 Kidney Week meeting in Chicago, Nov. 15-20. Poster FR-PO836.