Early RRT for AKI May Lower Risk of Dialysis Dependence

It also may shorten intensive care unit and hospital length of stay versus late RRT in critically ill patients, meta-analysis reveals.
It also may shorten intensive care unit and hospital length of stay versus late RRT in critically ill patients, meta-analysis reveals.

CHICAGO—Early initiation of renal replacement therapy (RRT) for acute kidney injury (AKI) in critically ill patients may decrease dependence on long-term dialysis, investigators reported at the American Society of Nephrology's 2016 Kidney Week meeting.

A systematic review and meta-analysis of 9 randomized controlled trials that included a total of 1599 critically ill patients showed that early RRT was associated with a significant 45% decreased risk of becoming dialysis dependent compared with late RRT, Rhea Bhargava, MD, of the University of Missouri-Kansas City School of Medicine, and colleagues concluded. Patients who had early RRT had a shorter stay (by a mean of 1.41 days) in the intensive care unit compared with patients who had late RRT and a short hospital length of stay (by a mean of 5.1 days). The investigators found no significant difference in mortality or adverse between the groups.

Click here for more coverage from the American Society of Nephrology's Kidney Week 2016 in Chicago.

Reference

  1. Bhargava R, Narsingam S, Grewal H, et al. Timing of renal replacement therapy in acute kidney injury: A systemic review and meta-analysis. Poster presented at the 2016 Kidney Week meeting in Chicago, Nov. 15-20. Poster FR-PO836.
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