Extended Hemodialysis May Improve Phosphate Control
Researchers observe significant decline in serum phosphate with 6 hours vs. 4 hours of treatment.
Investigators at Imperial College Hospital NHS Trust and North Bristol NHS Trust in the U.K. compared extended TT (6 hours) and standard TT (4 hours) on HD in a randomized, crossover study that included 29 patients. During the extended TT phase of the study, serum phosphate decreased significantly from 1.67 g/dL before treatment to 1.27 g/dL after 6 hours of treatment.
During the standard TT phase, serum phosphate increased significantly from 1.51 g/dL before treatment to 1.94 g/dL after 4 hours of treatment.
In addition, during the standard TT phase, researchers observed a significant increase in extracellular water, whereas during the extended TT phase, patients had no significant change in hydration status.
The study cohort included 27 men and 2 women with a mean age of 65 years.