Severe Periodontal Disease Ups Kidney Disease (CKD) Risk in African Americans

The condition is associated with a significant 4.2-fold greater incidence of chronic kidney disease.
The condition is associated with a significant 4.2-fold greater incidence of chronic kidney disease.

PHILADELPHIA—Severe periodontal disease is common among African-Americans and it is associated with clinically significant renal function decline, researchers reported at the 2014 Kidney Week meeting.

Vanessa Grubbs, MD, of the University of California San Francisco, and collaborators, conducted a longitudinal study of 699 African-American participants who underwent complete dental examinations as part of the Dental-Atherosclerosis Risk in Communities study (baseline 1996–1998) and subsequently enrolled in the Jackson Heart Study (follow-up 2000–2004).

Among subjects with a baseline estimated glomerular filtration rate (eGFR) above 60 mL/min/1.73 m2, the researchers defined incident chronic kidney disease (CKD) as an incident eGFR below 60 mL/min/1.73 m2 accompanied by a 5% annualized eGFR decline from baseline.

Of the 699 subjects, 114 (16.3%) had severe periodontal disease and 21 (3%) developed CKD during a mean follow-up of 4.8 years. Individuals with severe periodontal disease had a significant 4.2-fold greater incidence of CKD compared with those who did not have severe periodontal disease after adjusting for sex, age, hypertension, diabetes, smoking, and income.


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