Phosphorus and Disease Progression in Autosomal Dominant Polycystic Kidney Disease

SAN DIEGO—Dietary phosphorus may have an effect on the progression of autosomal dominant polycystic kidney disease (ADPKD), particularly in females, according to researchers at Kidney Week 2012.

Investigators led by Maria V. Irazabal, MD, examined a prospective, longitudinal multicenter study of 241 adults with ADPKD who demonstrated preserved renal function upon enrollment. They used a multiple regression model to look at the effect of urine volume and various excretions on log transformed total kidney volume (lnTKV) in both men and women.

Without adjusting for height or gender, urine volume and phosphorus excretions were positively correlated with lnTKV. Phosphorus excretions were positively correlated while calcium excretions were negatively correlated with lnTKV in women, while no significant correlations between the two were noted in men. Adjusting for baseline showed similar trends, with phosphorus excretions being significant in females and non-significant in males.

The researchers also tested the same models with phosphorus excretions and GFR, finding no significant associations or trends or associations based on gender.

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