Portable Home Dialysis Unit Improves QoL

PHILADELPHIA—End-stage renal disease patients who dialyzed with a portable hemodialysis (HD) system for 12 months reported improvements in their overall quality of life (QoL), according to findings presented at Kidney Week 2011.

Novel Therapy for CKD Anemia Advances

PHILADELPHIA—A novel treatment for chronic kidney disease (CKD) patients with anemia is showing positive results following a Phase 1/2 clinical trial, according to findings reported at Kidney Week 2011.

Gout Prevalence High in CKD Patients

PHILADELPHIA—Patients with chronic kidney disease (CKD) have a relatively high prevalence of gout compared with the general population, according to data presented at Kidney Week 2011.

Lower CKD Risk Found with High Salt Intake

Lower CKD Risk Found with High Salt Intake

PHILADELPHIA—High dietary salt intake may decrease the risk of chronic kidney disease (CKD) and low dietary potassium intake may increase the risk, investigators reported at Kidney Week 2011.

Calcifediol May Improve PTH Control, Nutritional Status

PHILADELPHIA—Adequate doses of calcifediol can correct 25-hydroxyvitamin D deficiency and improve malnutrition-inflammation status in hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT), researchers reported at Kidney Week 2011.

IV Iron Drug Shows Advantages in Head-to-Head Trial

PHILADELPHIA—Ferumoxytol has an efficacy comparable to iron sucrose in treating iron deficiency anemia in patients with chronic kidney disease (CKD), but is associated with lower adverse event (AE) rates, according to the findings a head-to-head comparison of the two formulations presented at Kidney Week 2011.

Once-Monthly ESA Maintains Stable Hemoglobin Levels

PHILADELPHIA—Once-monthly peginesatide, an investigational peptide-based erythropoiesis stimulating agent (ESA), is similar to epoetin administrated one to three times weekly in maintaining mean hemoglobin levels in the 10-12 g/dL range in hemodialysis patients with anemia, according to study findings presented at Kidney Week 2011.

Black Transplant Patients with FSGS Are At Higher Risk

PHILADELPHIA—Among kidney transplant recipients with focal segmental glomerulosclerosis (FSGS), African-Americans (AA) have a greater prevalence of risk factors for allograft failure compared with other races, according to findings presented at Kidney Week 2011.

High Pretransplant Phosphorus Raises Post-Transplant Death Risk

PHILADELPHIA—High pre-transplant serum phosphorus levels are associated with worse outcomes following renal transplantation, according to study findings presented at Kidney Week 2011.

Live Kidney Donation Raises Hypertension Risk in Blacks

PHILADELPHIA—Live kidney donation by African-Americans increases their risk of hypertension, researchers reported at Kidney Week 2011.

Cinacalcet Plus Low-Dose Vitamin D Improves SHPT Treatment

PHILADELPHIA—Cinacalcet plus low-dose vitamin D provides a more effective approach to treating secondary hyperparathyroidism (SHPT) in hemodialysis (HD) patients, according to findings presented at Kidney Week 2011.

Uncontrolled SHPT On the Rise in Blacks Since Debut of 'Bundling'

PHILADELPHIA—Uncontrolled secondary hyperparathyroidism (SHPT) has been on the increase among black hemodialysis (HD) patients since the recent implementation of the federal government's prospective payment system for dialysis services, researchers reported at Kidney Week 2011.

Increasing Phosphate Raises Death, CV Risks in Hemodialysis Patients

PHILADELPHIA—Baseline plasma phosphate level is an important risk factor for cardiovascular events and mortality in hemodialysis (HD) patients, investigators reported at Kidney Week 2011.

EPO Use Declining After Bundling Introduced

PHILADELPHIA—Epoetin alfa (EPO) use has decreased and intravenous (IV) iron use has increased significantly in private dialysis units since the introduction of the Medicare bundling rule for end-stage renal disease services, data presented at Kidney Week 2011 suggest.

Depressive Symptoms after Kidney Transplantation Are Associated with Decreased Survival

In a study presented at Kidney Week of 527 renal transplant recipients who had a median follow-up of seven years, researchers Dorien M. Zelle, MD, and colleagues at the University Medical Center Groningen in Groningen, the Netherlands, demonstrated that subjects who experienced depression following transplantation had an increased risk of death.

Predialysis Factors and the Timing of Dialysis Initiation among Older Adults

In a study presented at Kidney Week of 70,662 patients who initiated dialysis at 67 years or older, Deidra C. Crews, MD, of Johns Hopkins Medical Institutions in Baltimore, and colleagues found that a greater burden of comorbidities, frequent nephrology visits, and hospitalization for congestive heart failure were associated with early dialysis initiation.

Renal and Death Risks Lower with Metformin than Sulfonylureas

PHILADELPHIA—Initiating treatment of type 2 diabetes with sulfonylurea drugs is associated with an increased risk of renal function decline, end-stage renal disease (ESRD), or death compared with starting treatment on metformin, according to study findings presented at Kidney Week 2011.

Coronary Artery Calcification an MI Risk Factor in CKD Patients

PHILADELPHIA—Coronary artery calcification (CAC) provides additional predictive value for the risk of myocardial infarction (MI) in patients with chronic kidney disease (CKD), according to data presented at Kidney Week 2011.

Acute Rejection Risk Higher with Membranous Glomerulonephritis

PHILADELPHIA—Membranous glomerulonephritis (GN) is the most common form of primary GN associated with acute renal allograft rejection following renal transplantation, researchers reported at Kidney Week 2011.

Pretransplant ESA Hyporesponsiveness May Worsen Post-Transplant Outcomes

PHILADELPHIA—Two research teams have found that hyporesponsiveness to erythropoiesis stimulating agents (ESAs) prior to renal transplantation is associated with a higher risk of post-transplant allograft failure and mortality, according to study findings presented at Kidney Week 2011.

Worsening Post-Transplant CKD Predicts Higher Graft Failure Risk

PHILADELPHIA—Worsening of chronic kidney disease (CKD) stage in the first year following renal transplantation is associated with an increased risk of graft failure, researchers reported at Kidney Week.

Untreated SHPT Increases Mortality Risk

PHILADELPHIA—Untreated secondary hyperparathyroidism (SHPT) is associated with increased mortality risk in hemodialysis (HD) patients, according to a report presented at Kidney Week 2011.

Treating SHPT with Cinacalcet Lowers Phosphorus

PHILADELPHIA—Serum phosphorus levels in hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT) decrease during treatment with cinacalcet, data presented at Kidney Week 2011 show. This effect occurs regardless of baseline SHPT severity.

Two Vitamin D Analogues Show Similar Efficacy for SHPT

PHILADELPHIA—Alfacalcidol and paricalcitol have similar efficacy in suppressing secondary hyperparathyroidism (SHPT) in hemodialysis (HD) patients researchers reported at Kidney Week 2011.

High FGF-23 in AKI Patients Predicts Worse Outcomes

PHILADELPHIA—Levels of fibroblast growth factor 23 (FGF-23) are elevated in acute kidney injury (AKI) and are associated with an increased risk of death or need for renal replacement therapy (RRT), data presented at Kidney Week 2011 suggest.

IV Iron Use for Anemia Rising, ESA Use Falling

PHILADELPHIA—The use of intravenous (IV) iron for managing anemia in hemodialysis (HD) patients has increased steadily from 2002 to 2008, even after declines in the use of erythropoiesis stimulating agents (ESAs), as reported from data presented at Kidney Week 2011.

HD-Related Damage Not a Factor in CKD-Related Anemia

PHILADELPHIA—Mechanical damage to red blood cells (RBC) from hemodialysis (HD) does not contribute to anemia in HD patients, according to study findings presented at Kidney Week 2011.

Response to ESAs Predicts ESRD Risk

PHILADELPHIA—Patients with chronic kidney disease (CKD) who have a low response to erythropoiesis-stimulating agents (ESAs) are at increased risk of progressing to end-stage renal disease (ESRD), investigators reported at Kidney Week 2011.

Predialysis Renal Decline Patterns Identified

PHILADELPHIA—Researchers have found substantial heterogeneity in trajectories of renal function during the two-year period leading up to initiation of chronic dialysis, according to a report presented at Kidney Week 2011.

Rapid Renal Decline in the Elderly Linked to Systolic Blood Pressure

PHILADELPHIA—Elevated systolic blood pressure (SBP) contributes substantially to rapid declines in renal function in older adults, investigators reported at Kidney Week 2011.

Dialysis-Requiring AKI Rises Sharply

PHILADELPHIA—Acute kidney injury (AKI), also known as acute renal failure, requiring dialysis has become more common than end-stage renal disease (ESRD) requiring renal replacement therapy (RRT), according to findings presented at Kidney Week 2011.

ESA Resistance Increases Death Risk More in HD than PD Patients

PHILADELPHIA—Most patients on peritoneal dialysis (PD) receive substantially lower doses of erythropoiesis stimulating agents (ESAs) for the same achieved hemoglobin levels compared with patients on hemodialysis (HD), investigators reported at Kidney Week 2011.

Vitamin D Regimen May Treat SHPT in Renal Transplant Patients

Vitamin D Regimen May Treat SHPT in Renal Transplant Patients

PHILADELPHIA—Cholecalciferol with or without doxercalciferol may be an appropriate treatment for secondary hyperparathyroidism (SHPT) in kidney transplant recipients, according to the findings of a small study presented at Kidney Week 2011.

FGF-23 Levels Are Elevated in Children, Adults with Autosomal Dominant Polycystic Kidney Disease, Preserved Renal Function

Fibroblast growth factor 23 (FGF-23) levels, which have been shown previously to be elevated in adults with autosomal polycystic kidney disease (ADPKD), are elevated early in the course of the disease, when kidney function is intact, investigators reported at Kidney Week 2011.

Long-Term Risks of Hospital Readmission, Death in Patients with Kidney Disease

Long-term risks of hospital readmission and death for patients with chronic kidney disease or who are on dialysis or have received a kidney transplant were among the highest observed in a large, statewide population, according to study findings presented at Kidney Week 2011.

Predictors of Hospitalizations in Maintenance HD Patients

A study of 5,758 hemodialysis patients showed a significant association between hospitalization and potentially modifiable indicators of fluid overload (for example, interdialytic weight gain), anemia management (hemoglobin levels and transferrin saturation), and vascular access (catheter), investigators reported at Kidney Week 2011.

EC-MPS, MMF Similar in Efficacy in Tacrolimus-Treated Transplant Patients

PHILADELPHIA—Enteric-coated mycophenolate sodium (EC-MPS) and mycophenolate mofetil (MMF) are associated with similar outcomes in renal transplant patients receiving tacrolimus, according to study findings presented at Kidney Week 2011.

BP Rises with ESAs Not Relate to Vasoconstriction

PHILADELPHIA—New study findings may narrow down the possible causes of increased blood pressure (BP) result from the use of erythropoiesis stimulating agents (ESAs) to correct renal anemia, according to a report presented at Kidney Week 2011.

Diabetes Boosts CKD Patients' Comorbidities

PHILADELPHIA—Patients with chronic kidney disease (CKD) who also have diabetes have significantly higher rates of anemia, cardiovascular disease, and other comorbidities compared with nondiabetic CKD patients, study findings presented at Kidney Week 2011 show.

High PTH and FGF-23 Predict Vascular Calcification

PHILADELPHIA—Elevated levels of serum parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23) are associated with an increased likelihood of progression of vascular calcification (VC) in hemodialysis patients, French researchers reported at Kidney Week 2011.

Study Identifies Predictors of Cinacalcet Use After Transplantation

PHILADELPHIA—The dose of cinacalcet dialysis patients receive prior to renal transplantation and their time on dialysis appear to be the most important factors associated with reintroduction of the drug during the first year following transplantation, Spanish researchers reported at Kidney Week 2011.

Renal Function Declines in Living Kidney Donors

PHILADELPHIA—Substantial proportions of living kidney donors have diminished renal function one year following their nephrectomy, investigators reported at Kidney Week 2011.

Study Hints at Why Diabetics Are Less Likely to Receive a Renal Transplant

PHILADELPHIA—Diabetics are less likely to be placed on a waiting list for a renal transplant and are less likely to be transplanted, according to findings reported at Kidney Week 2011.

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