Acute Rejection Risk Higher with Membranous Glomerulonephritis

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PHILADELPHIA—Membranous glomerulonephritis (GN) is the most common form of primary GN associated with acute renal allograft rejection following renal transplantation, researchers reported at Kidney Week 2011.

The risk of acute rejection is a significant 59% greater with membranous GN compared with other GNs (focal segmental, membranoproliferative, and IgA nephropathy), according to a research team led by Arjang Djamali, MD, FASN, of the University of Wisconsin School of Medicine and Public Health in Madison. At three years, 50% of patients with membranous GN had an episode of acute rejection.

The retrospective study, which included 598 renal transplant recipients with biopsy confirmed primary GN, showed that delayed graft function was associated with a significant 2.3 times increased risk of acute rejection in patients with membranous GN and basiliximab induction was associated with a significant 61% decreased risk.

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