Typical Vitamin D Doses May Not Increase Kidney Stone Risk

After multivariate adjustment there was no statistically significant association between vitamin D intake and risk of stones in the follow-up study.
After multivariate adjustment there was no statistically significant association between vitamin D intake and risk of stones in the follow-up study.

(HealthDay News) — There is no statistically significant correlation between typical vitamin D intake and incident kidney stones, according to a study published in The Journal of Urology.

Pietro Manuel Ferraro, MD, PhD, from Catholic University of the Sacred Heart in Rome, and colleagues conducted a prospective analysis of 193,551 participants in the Health Professionals Follow-up Study (HPFS) and Nurses' Health Study (NHS) I and II to examine the correlation between vitamin D intake and risk of incident kidney stones. Participants were categorized according to total and supplemental vitamin D intake.

There were 6576 incident kidney stone events during a follow-up of 3,316,846 person-years. The researchers found that there was no statistically significant correlation between vitamin D intake and risk of stones in the HPFS (hazard ratio for 1000 or more versus less than 100 IU per day, 1.08; 95% CI, 0.8 to 1.47; P for trend = 0.92) and the NHS I (hazard ratio, 0.99; 95% CI, 0.73 to 1.35; P for trend = 0.70), while there was a suggestion of higher risk in the NHS II (hazard ratio, 1.18; 95% CI, 0.94 to 1.48; P for trend = 0.02) after multivariate adjustment. For supplemental vitamin D intake, the results were similar.

"Vitamin D intake in typical amounts was not statistically associated with risk of kidney stone formation, although higher risk with higher doses than those studied here cannot be excluded," the authors write.

One author disclosed financial ties to Allena Pharmaceuticals and UpToDate.

Reference

  1. Ferraro PM, Taylor EN, Gambaro G, Curhan GC. Vitamin D Intake and the Risk of Incident Kidney Stones. J Urol. 18 August 2016. doi: 10.1016/j.juro.2016.08.084.
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