Coronary Heart Disease Linked to Kidney Stones in Women

Women with a history of kidney stones are at elevated risk of coronary heart disease (CHD), according to a new study.

Pietro Manuel Ferraro, MD, of Columbus-Gemelli Hospital in Rome, Italy, and collaborators analyzed data from participants in the Nurses' Health Study I (NHS I), which enrolled 90,235 women aged 30-55; the Nurses' Health Study II (NHS II), which enrolled 106,122 women aged 22-42 years); and the Health Professionals Follow-up Study (HPFS), which enrolled 45,748 men aged 40-75 years.

Of a total of 242,105 subjects, 19,678 reported a history of kidney stones. After up to 18 years of follow-up in women and 24 years in men, 16,838 CHD cases developed. Among women in NHS I, those with a history of kidney stones had a significant 18% higher risk of CHD than women without a history of kidney stones, after adjusting for potential confounders, the investigators reported in the Journal of the American Medical Association (2013;310:408-415). Among women in NHS II, a history of kidney stones was associated with a significant 48% increased risk of CHD. The researchers found no association between kidney stone history and CHD in men.

For the study, Dr. Ferraro's group defined CHD as fatal or nonfatal myocardial infarction or coronary revascularization.

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