Alfuzosin Safe, Effective for Ureteral Stone Expulsion
Stone-free rate and expulsion time did not differ significantly between alfuzosin and tamsulosin.
Alfuzosin is safe and effective for use as medical expulsive therapy for ureteral stones less than 10 mm in diameter, according to the findings of a systematic review and meta-analysis published online in PLoS One.
Chenli Liu, MD, and colleagues at The First Affiliated Hospital of Guangzhou Medical University in Guangdong, China, analyzed data from 9 studies that met the study's selection criteria. These studies included 291 patients who received alfuzosin 10 mg, 134 who received tamsulosin 0.4 mg, and 280 who received conservative therapy (controls).
Compared with controls, alfuzosin-treated patients had a significant 85% increased likelihood of becoming stone-free and a significant 4 day shorter expulsion time. Stone-free rate and expulsion time did not differ significantly between alfuzosin and tamsulosin. Both drugs had similar complication rates. Pooled analysis showed a significantly lower frequency of retrograde ejaculation in the alfuzosin group than the tamsulosin group.