Kidney Cancer

Blood Transfusion Predicts Worse Outcomes After Nephrectomy for RCC

Blood Transfusion Predicts Worse Outcomes After Nephrectomy for RCC

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Perioperative blood transfusion is associated with increased risks of tumor recurrence, metastatic progression, and cancer-related mortality.

Overweight-Related Cancers Common in the US

Overweight-Related Cancers Common in the US

40% of cancer diagnoses tied to extra weight; rate higher in older individuals, females.

RCC Subtypes Affect Post-Surgery Cancer-Related Mortality Risk

RCC Subtypes Affect Post-Surgery Cancer-Related Mortality Risk

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Patients with papillary versus clear cell renal cell carcinoma have a 24% decreased risk of dying from their cancer.

CKD Risk Lower With Partial Nephrectomy

CKD Risk Lower With Partial Nephrectomy

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In a study, partial nephrectomy was associated with a 66% lower risk for stage 4 or higher CKD versus radical nephrectomy.

Various Neurological Complications Tied to Anti-PD-1 Therapy

Various Neurological Complications Tied to Anti-PD-1 Therapy

The researchers found that 2.9% of the 347 patients treated with anti-PD-1 monoclonal antibodies developed subacute onset of neurological complications.

FDA Approves First Biosimilar for Kidney Cancer Treatment

FDA Approves First Biosimilar for Kidney Cancer Treatment

Mvasi, which is approved to treat colorectal, lung, brain, kidney, and cervical cancer, was found to be biosimilar to the drug Avastin.

Immunotherapy Superior to Sunitinib for Front-Line mRCC Treatment

Immunotherapy Superior to Sunitinib for Front-Line mRCC Treatment

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Checkpoint inhibitor combination of nivolumab plus ipilimumab improved progression-free and overall survival compared with sunitinib.

Upfront Cabozantinib for Advanced RCC Improves Outcomes

Upfront Cabozantinib for Advanced RCC Improves Outcomes

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Cabozantinib reduced the risk of disease progression or death compared with sunitinib among patients with previously untreated advanced renal cell carcinoma.

Early NLR Changes Predict mRCC Immunotherapy Outcomes

Early NLR Changes Predict mRCC Immunotherapy Outcomes

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Rises and decreases in neutrophil-to-lymphocyte ratio at 6 weeks after treatment with anti-PD-1/PD-L1 immune checkpoint blockade is associated with progression-free and overall survival.

Energy Dense Diet Increases Obesity-Related Cancer Risk

Energy Dense Diet Increases Obesity-Related Cancer Risk

The increased risk for obesity-related cancer was seen among women who were normal weight at enrollment.

Geriatric Consultation Uncommon in Kidney Cancer Surgery

Geriatric Consultation Uncommon in Kidney Cancer Surgery

Participant age and comorbidity burden appeared to be consistent determinants of use of services, although hospital-level variation was also noted.

Combo Immunotherapy May Change Treatment for Kidney Cancer

Combo Immunotherapy May Change Treatment for Kidney Cancer

Response rates of the combination therapy increasing from 20% to 40%.

Targeted Multigene Panel Testing Useful for Hereditary Kidney Cancer

Targeted Multigene Panel Testing Useful for Hereditary Kidney Cancer

The most commonly altered genes were folliculin and fumarate hydratase in 1.8% and 1.3%, respectively.

Video: New Drug Proves Effective For Renal Cell Cancer Patients

Video: New Drug Proves Effective For Renal Cell Cancer Patients

Nivolumab combined with ipilimumab revealed manageable safety, antitumor activity and favorable responses garnering potential long-term benefits.

Type of Long-term Response to Targeted mRCC Therapy Affects Outcomes

Type of Long-term Response to Targeted mRCC Therapy Affects Outcomes

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Patients who have a complete response to 2 or more years of anti-VEGF treatment have the best progression-free and overall survival.

What Not to Eat After Nephrectomy

What Not to Eat After Nephrectomy

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Both urologists and nephrologists provide follow-up and continuity of care to patients after cancer nephrectomy.

BMI, Belly Fat Suggest Obesity-Related Cancer Risk

BMI, Belly Fat Suggest Obesity-Related Cancer Risk

BMI and location of excess body fat on the body are good indicators of obesity-related cancer risk.

Renal, Bladder Cancer Linked to Physical Inactivity

Renal, Bladder Cancer Linked to Physical Inactivity

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Renal and bladder cancer patients were, respectively, 77% and 73% more likely to report lifetime physical inactivity than controls without cancer.

AUA Releases Updated Renal Mass Guidelines

AUA Releases Updated Renal Mass Guidelines

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The document spells out in greater detail the criteria for radical and partial nephrectomy and for placing patients on active surveillance.

Early CRP Response to mRCC Drugs Predicts Survival

Early CRP Response to mRCC Drugs Predicts Survival

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Changes in C-reactive protein levels 4 weeks after starting sunitinib or sorafenib treatment are associated with overall and progression-free survival.

AS Safe for Cystic Renal Masses in Selected Patients

AS Safe for Cystic Renal Masses in Selected Patients

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In a single-center study, 24% of patients crossed over to treatment and 95% of patients were alive after 5 years of follow-up.

RCC Patients May Benefit from Nivolumab After Disease Progression

RCC Patients May Benefit from Nivolumab After Disease Progression

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Nivolumab treatment beyond disease progression results in reductions in tumor burden, study finds.

 Recurrence of Low-Risk RCC Uncommon After Surgery

Recurrence of Low-Risk RCC Uncommon After Surgery

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In a study, the 5-year risk of recurrence was 4.8%, 18.1%, and 46.3% for patients with low-, intermediate-, and high-risk disease.

Kidney Cancer Survival Better Among Metformin Users

Kidney Cancer Survival Better Among Metformin Users

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Patients who used the drug had a 38% lower risk of dying from kidney cancer than non-users, meta-analysis shows.

Obesity and Kidney Disease: Hidden Consequences of the Epidemic

Obesity and Kidney Disease: Hidden Consequences of the Epidemic

World Kidney Day 2017 promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle and health policy measures that makes preventive behaviors an affordable option.

Targeted Therapies for Advanced RCC Improve Real-World Survival

Targeted Therapies for Advanced RCC Improve Real-World Survival

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Overall survival among patients receiving first-line targeted therapy for advanced renal cell carcinoma increased significantly from 2006 to 2012.

Kidney Cancer Linked to Obesity

Kidney Cancer Linked to Obesity

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Study also finds associations between adiposity and 10 other cancers, particularly digestive and hormone-related malignancies.

Broad-spectrum Antibiotics May Reduce Survival in mRCC

Broad-spectrum Antibiotics May Reduce Survival in mRCC

The researchers found that patients treated with ABT had decreased progression-free survival compared with those not receiving ATB.

Biologics Combo Shows Promise As First-Line mRCC Therapy

Biologics Combo Shows Promise As First-Line mRCC Therapy

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In a phase 2 trial, atezolizumab plus bevacizumab improved PFS versus sunitinib in patients with renal cell carcinoma expressing PD-L1.

Sunitinib Dose Escalation May Benefit mRCC Patients

Sunitinib Dose Escalation May Benefit mRCC Patients

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Added progression-free survival and prolonged overall survival possible, according to investigators.

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