Kidney Cancer News Archive

RCC Treatment Costs Could Negatively Affect Health

RCC Treatment Costs Could Negatively Affect Health

Access to treatment should be considered as important as the research leading to clinical improvements.

Radical Nephrectomy Linked With Worse Kidney Function, Survival

Radical Nephrectomy Linked With Worse Kidney Function, Survival

Patients who underwent radical nephrectomy had 2-fold greater decline in eGFR decline and 2-fold greater mortality compared with those who had a partial nephrectomy.

Cabozantinib Improves Survival, Response in Bone-metastatic RCC

Cabozantinib Improves Survival, Response in Bone-metastatic RCC

Patients who received cabozantinib were also less likely to have skeletal-related events (23% vs 29% with everolimus).

SABR for Renal Cell Carcinoma Offers Excellent Outcomes

SABR for Renal Cell Carcinoma Offers Excellent Outcomes

Stereotactic ablative radiotherapy is associated with high 2- and 4-year rates of local cancer control and progression-free and cancer-specific survival.

Conversion of Robotic Partial to Radical Nephrectomy Is Uncommon

Conversion of Robotic Partial to Radical Nephrectomy Is Uncommon

In a multinational, prospective study, just 5% of cases converted.

Adverse Events Up for Autoimmune Disease Pts on Checkpoint Inhibitors

Adverse Events Up for Autoimmune Disease Pts on Checkpoint Inhibitors

Most patients with cancer, autoimmune disease have improvement in events without discontinuing therapy.

Fatigue Tied With Sorafenib, Sunitinib Use in Renal Cell Carcinoma

Fatigue Tied With Sorafenib, Sunitinib Use in Renal Cell Carcinoma

Although TKIs improve outcomes, they are still associated with toxicities common with cancer therapies, such as fatigue.

Partial Nephrectomy Improves Survival in cT1b RCC Cases

Partial Nephrectomy Improves Survival in cT1b RCC Cases

Partial nephrectomy was associated with decreased odds of death versus radical nephrectomy among patients with cT1b but not cT2 renal cell carcinoma.

FDA Approves Cabometyx for First-Line Treatment of Advanced RCC

FDA Approves Cabometyx for First-Line Treatment of Advanced RCC

Treatment with cabozantinib led to a clinically meaningful improvement in progression-free survival compared with sunitinib.

Cytoreductive Nephrectomy Benefits for Metastatic RCC Demonstrated

Cytoreductive Nephrectomy Benefits for Metastatic RCC Demonstrated

Patients who underwent cytoreductive nephrectomy for metastatic non-clear cell renal cell carcinoma had a significantly decreased risk of cancer-related mortality.

Kidney Cancer Bone Metastasis Predictors Id'd

Kidney Cancer Bone Metastasis Predictors Id'd

Levels of alkaline phosphatase, calcium, and hemoglobin can independently predict bone metastasis in patients with renal cell carcinoma, Chinese investigators report.

Cytoreductive Nephrectomy Improves Survival in mRCC

Cytoreductive Nephrectomy Improves Survival in mRCC

Propensity score matching showed a 5.8 month survival advantage for initial CN vs initial systematic therapy.

FDA Approves Sunitinib for Adjuvant Treatment of RCC

FDA Approves Sunitinib for Adjuvant Treatment of RCC

At 5 years, 59.3% of patients treated with sunitinib were free from recurrence versus 51.3% who received placebo.

Radical Nephrectomy Costs, Operating Time Greater With Robotics

Radical Nephrectomy Costs, Operating Time Greater With Robotics

Robotic-assisted radical nephrectomy (RN) is associated with higher hospital costs and prolonged operating time compared with laparoscopic RN.

Blood Transfusion Predicts Worse Outcomes After Nephrectomy for RCC

Blood Transfusion Predicts Worse Outcomes After Nephrectomy for RCC

Perioperative blood transfusion is associated with increased risks of tumor recurrence, metastatic progression, and cancer-related mortality.

Overweight-Related Cancers Common in the US

Overweight-Related Cancers Common in the US

40% of cancer diagnoses tied to extra weight; rate higher in older individuals, females.

RCC Subtypes Affect Post-Surgery Cancer-Related Mortality Risk

RCC Subtypes Affect Post-Surgery Cancer-Related Mortality Risk

Patients with papillary versus clear cell renal cell carcinoma have a 24% decreased risk of dying from their cancer.

CKD Risk Lower With Partial Nephrectomy

CKD Risk Lower With Partial Nephrectomy

In a study, partial nephrectomy was associated with a 66% lower risk for stage 4 or higher CKD versus radical nephrectomy.

Various Neurological Complications Tied to Anti-PD-1 Therapy

Various Neurological Complications Tied to Anti-PD-1 Therapy

The researchers found that 2.9% of the 347 patients treated with anti-PD-1 monoclonal antibodies developed subacute onset of neurological complications.

FDA Approves First Biosimilar for Kidney Cancer Treatment

FDA Approves First Biosimilar for Kidney Cancer Treatment

Mvasi, which is approved to treat colorectal, lung, brain, kidney, and cervical cancer, was found to be biosimilar to the drug Avastin.

Immunotherapy Superior to Sunitinib for Front-Line mRCC Treatment

Immunotherapy Superior to Sunitinib for Front-Line mRCC Treatment

Checkpoint inhibitor combination of nivolumab plus ipilimumab improved progression-free and overall survival compared with sunitinib.

Upfront Cabozantinib for Advanced RCC Improves Outcomes

Upfront Cabozantinib for Advanced RCC Improves Outcomes

Cabozantinib reduced the risk of disease progression or death compared with sunitinib among patients with previously untreated advanced renal cell carcinoma.

Early NLR Changes Predict mRCC Immunotherapy Outcomes

Early NLR Changes Predict mRCC Immunotherapy Outcomes

Rises and decreases in neutrophil-to-lymphocyte ratio at 6 weeks after treatment with anti-PD-1/PD-L1 immune checkpoint blockade is associated with progression-free and overall survival.

Energy Dense Diet Increases Obesity-Related Cancer Risk

Energy Dense Diet Increases Obesity-Related Cancer Risk

The increased risk for obesity-related cancer was seen among women who were normal weight at enrollment.

Geriatric Consultation Uncommon in Kidney Cancer Surgery

Geriatric Consultation Uncommon in Kidney Cancer Surgery

Participant age and comorbidity burden appeared to be consistent determinants of use of services, although hospital-level variation was also noted.

Targeted Multigene Panel Testing Useful for Hereditary Kidney Cancer

Targeted Multigene Panel Testing Useful for Hereditary Kidney Cancer

The most commonly altered genes were folliculin and fumarate hydratase in 1.8% and 1.3%, respectively.

Type of Long-term Response to Targeted mRCC Therapy Affects Outcomes

Type of Long-term Response to Targeted mRCC Therapy Affects Outcomes

Patients who have a complete response to 2 or more years of anti-VEGF treatment have the best progression-free and overall survival.

BMI, Belly Fat Suggest Obesity-Related Cancer Risk

BMI, Belly Fat Suggest Obesity-Related Cancer Risk

BMI and location of excess body fat on the body are good indicators of obesity-related cancer risk.

Renal, Bladder Cancer Linked to Physical Inactivity

Renal, Bladder Cancer Linked to Physical Inactivity

Renal and bladder cancer patients were, respectively, 77% and 73% more likely to report lifetime physical inactivity than controls without cancer.

AUA Releases Updated Renal Mass Guidelines

AUA Releases Updated Renal Mass Guidelines

The document spells out in greater detail the criteria for radical and partial nephrectomy and for placing patients on active surveillance.

Early CRP Response to mRCC Drugs Predicts Survival

Early CRP Response to mRCC Drugs Predicts Survival

Changes in C-reactive protein levels 4 weeks after starting sunitinib or sorafenib treatment are associated with overall and progression-free survival.

AS Safe for Cystic Renal Masses in Selected Patients

AS Safe for Cystic Renal Masses in Selected Patients

In a single-center study, 24% of patients crossed over to treatment and 95% of patients were alive after 5 years of follow-up.

RCC Patients May Benefit from Nivolumab After Disease Progression

RCC Patients May Benefit from Nivolumab After Disease Progression

Nivolumab treatment beyond disease progression results in reductions in tumor burden, study finds.

Recurrence of Low-Risk RCC Uncommon After Surgery

Recurrence of Low-Risk RCC Uncommon After Surgery

In a study, the 5-year risk of recurrence was 4.8%, 18.1%, and 46.3% for patients with low-, intermediate-, and high-risk disease.

Kidney Cancer Survival Better Among Metformin Users

Kidney Cancer Survival Better Among Metformin Users

Patients who used the drug had a 38% lower risk of dying from kidney cancer than non-users, meta-analysis shows.

Targeted Therapies for Advanced RCC Improve Real-World Survival

Targeted Therapies for Advanced RCC Improve Real-World Survival

Overall survival among patients receiving first-line targeted therapy for advanced renal cell carcinoma increased significantly from 2006 to 2012.

Kidney Cancer Linked to Obesity

Kidney Cancer Linked to Obesity

Study also finds associations between adiposity and 10 other cancers, particularly digestive and hormone-related malignancies.

Broad-spectrum Antibiotics May Reduce Survival in mRCC

Broad-spectrum Antibiotics May Reduce Survival in mRCC

The researchers found that patients treated with ABT had decreased progression-free survival compared with those not receiving ATB.

Biologics Combo Shows Promise As First-Line mRCC Therapy

Biologics Combo Shows Promise As First-Line mRCC Therapy

In a phase 2 trial, atezolizumab plus bevacizumab improved PFS versus sunitinib in patients with renal cell carcinoma expressing PD-L1.

Sunitinib Dose Escalation May Benefit mRCC Patients

Sunitinib Dose Escalation May Benefit mRCC Patients

Added progression-free survival and prolonged overall survival possible, according to investigators.

Kidney Cancer Brain Metastases Not On the Rise

Kidney Cancer Brain Metastases Not On the Rise

Researchers develop a model to predict which patients are more likely to harbor brain metastases at cancer diagnosis.

Single RCC Bone Metastasis Predicts Better Survival

Single RCC Bone Metastasis Predicts Better Survival

Bone surgery should be considered in patients with solitary bone metastasis and no concomitant visceral metastases, according to investigators.

Metabolic Profiles May Distinguish RCC From Benign Masses

Metabolic Profiles May Distinguish RCC From Benign Masses

In a pilot study, metabolomic analyses of serum and urine showed a high level of predictive ability.

Guidelines Issued for Managing Small Renal Masses

Guidelines Issued for Managing Small Renal Masses

All patients with an SRM should be considered for a biopsy when the results may alter management.

Benign Disease Found in 14% of PN Cases

Benign Disease Found in 14% of PN Cases

The most common types of benign pathology were oncocytoma, angiomyolipoma, and complex cysts.

Office-Based Renal Mass Biopsy Safe

Office-Based Renal Mass Biopsy Safe

In a study, only 3 of 108 patients experienced complications, all of which were minor and required no hospitalization or further intervention.

Robotic Nephrectomy for Localized RCC On The Rise

Robotic Nephrectomy for Localized RCC On The Rise

In 2013, nearly one third of all minimally invasive radical nephrectomies were performed with robotic assistance.

Study: Older Age Should Not Preclude Partial Nephrectomy

Study: Older Age Should Not Preclude Partial Nephrectomy

Partial and radical nephrectomy were associated with similar cancer-specific and overall survival in elderly patients.

CB-839 Drug Promising for Clear Cell, Papillary Renal Cell Cancer

CB-839 Drug Promising for Clear Cell, Papillary Renal Cell Cancer

In the 15 patients in the study, the dual treatment controlled tumors in 93% of the patients, who had either clear cell or papillary renal cell cancer.

Age at Cancer Diagnosis Predicts Cardiac Risk

Age at Cancer Diagnosis Predicts Cardiac Risk

Cancer patients diagnosed in their teens had a more than 4-fold higher risk of death from cardiac disease than patients who didn't have cancer.

Robotic Partial Nephrectomy Offers Better Morbidity Than Laparoscopic

Robotic Partial Nephrectomy Offers Better Morbidity Than Laparoscopic

Robotic partial nephrectomy confers a superior morbidity profile compared to laparoscopic partial nephrectomy.

Renal-Cell Cancer Disease-Free Survival Up With Sunitinib

Renal-Cell Cancer Disease-Free Survival Up With Sunitinib

Among patients with clear-cell renal-cell carcinoma at high risk for tumor recurrence, the duration of disease-free survival was significantly longer in the sunitinib group.

Obesity Ups Risk for Secondary Primary Cancers in Men

Obesity Ups Risk for Secondary Primary Cancers in Men

Prediagnosis obesity is a risk factor for overall and individual secondary primary cancers.

Cabozantinib Superior as Front-Line Therapy for Advanced RCC

Cabozantinib Superior as Front-Line Therapy for Advanced RCC

Use of the drug is associated with significantly longer progression-free survival compared with suninitib in treatment-naïve patients.

Partial Nephrectomy Use Increasing

Partial Nephrectomy Use Increasing

Study of US veterans reveals, however, that the procedure is being used less in subgroups who might benefit the most.

TKI Dose Escalation After mRCC Progression Beneficial

TKI Dose Escalation After mRCC Progression Beneficial

In a small study, researchers observed a decrease in tumor burden and extended duration of therapy.

Immunotherapy Increasingly Used in Cancer Care

Immunotherapy Increasingly Used in Cancer Care

Immunotherapy treatments for patients with bladder cancer, head and neck cancer, Hodgkin's lymphoma, and kidney cancer, is useful against malignancy, according to Cancer Progress Report.

Data Support Biopsy Before Renal Cryo

Data Support Biopsy Before Renal Cryo

The recurrence group had significantly larger tumors than the no-recurrence group.

Higher Complication Rate Found With Open Partial Nephrectomy

Higher Complication Rate Found With Open Partial Nephrectomy

Open partial nephrectomy had a significantly higher rate of complications.

High BMI Predicts Improved RCC Patient Survival

High BMI Predicts Improved RCC Patient Survival

Paradoxical association could be related to an altered fatty acid pathway.

Slimmer People Have Lower Risks of Kidney, Other Cancers

Slimmer People Have Lower Risks of Kidney, Other Cancers

International committee finds slimmer individuals less likely to develop variety of malignancies.

Robotic, Open PN Similarly Effective for Endophytic Kidney Tumors

Robotic, Open PN Similarly Effective for Endophytic Kidney Tumors

Robotic surgery may offer some benefits, such as shorter hospital stay and less blood loss.

Kidney Cancer Risk Linked to Metalworking Fluids

Kidney Cancer Risk Linked to Metalworking Fluids

Mean exposure of 18.80 mg/m3 per year was associated with a significant 11% increased risk among white men.

Active Surveillance Possible Before Treatment in mRCC

Active Surveillance Possible Before Treatment in mRCC

Some metastatic RCC patients may safely undergo surveillance prior to starting systematic therapy.

Metabolic Factors Linked to RCC Treatment Resistance

Metabolic Factors Linked to RCC Treatment Resistance

Research results provide potential new targets for combination therapy regimens.

Aspirin Does Not Hike Kidney Surgery Bleeding Complications

Aspirin Does Not Hike Kidney Surgery Bleeding Complications

Study finds no increased risk of overall complications in patients undergoing robotic partial nephrectomy.

Chest X-Rays May Miss Pulmonary Metastases in T1a RCC Patients

Chest X-Rays May Miss Pulmonary Metastases in T1a RCC Patients

Findings in patients treated for T1a renal cell carcinoma followed with X-ray surveillance.

Smaller Renal Tumors Predict Longer Surgical Wait Times

Smaller Renal Tumors Predict Longer Surgical Wait Times

Patients whose surgical wait time was 3 months or more versus less than 3 months had 10-fold increased odds of having a smaller tumor.

Disseminated Cancer Increases Nephrectomy Complication Rate

Disseminated Cancer Increases Nephrectomy Complication Rate

Disseminated cancer at the time of radical nephrectomy is associated with 2-fold increased odds of major perioperative complications.

Laparoscopic Nephrectomy May Be Performed as Outpatient Surgery

Laparoscopic Nephrectomy May Be Performed as Outpatient Surgery

Most patients discharged home within first 6 hours after surgery; none readmitted.

Cabozantinib Shows Superiority in Treating Advanced mRCC

Cabozantinib Shows Superiority in Treating Advanced mRCC

The drug significantly improves overall and progression-free survival compared with everolimus, researchers report.

Early Tumor Shrinkage Predicts mRCC Treatment Outcomes

Early Tumor Shrinkage Predicts mRCC Treatment Outcomes

The optimal tumor shrinkage threshold for predicting overall and progression-free survival is 10%, researchers concluded.

Achieving 4 Lifestyle Standards May Reduce Cancer Mortality

Achieving 4 Lifestyle Standards May Reduce Cancer Mortality

Four key lifestyle factors include weight, exercise, no smoking, and limiting alcohol.

Leisure Activity Linked With Lower Risk of Several Cancers

Leisure Activity Linked With Lower Risk of Several Cancers

Findings for self-reported leisure-time physical activity of moderate to vigorous intensity.

Higher Cancer Risk in Dialysis Patients Confirmed

Higher Cancer Risk in Dialysis Patients Confirmed

The risk is most elevated among individuals aged 44 years or younger.

AKI After RCC Surgery On the Rise

AKI After RCC Surgery On the Rise

Nearly 6% of patients who underwent partial or radical nephrectomy between 1998 and 2010 developed AKI.

Survival Advantage Confirmed for Nephrectomy in mRCC

Survival Advantage Confirmed for Nephrectomy in mRCC

About 25% of patients who present with metastatic renal cancer will undergo nephrectomy after diagnosis.

Cytoreductive Nephrectomy Benefits Select mRCC Patients Taking TT

Cytoreductive Nephrectomy Benefits Select mRCC Patients Taking TT

Among patients treated with targeted therapy, overall survival was 17.1 months for CN recipients vs 7.7 months for those without CN.

Renal Transplant Patients At Higher Risk of Papillary RCC

Renal Transplant Patients At Higher Risk of Papillary RCC

Only this histologic variant occurs at a significantly higher incidence in renal allograft recipients than the non-transplant population.

More mRCC Patients Receiving Treatment

More mRCC Patients Receiving Treatment

Cytoreductive nephrectomy (CN) use remained stable in the targeted therapy era, but more patients are receiving a combination of CN and systemic therapy.

Partial Nephrectomy Feasible for T3a Renal Cell Carcinoma

Partial Nephrectomy Feasible for T3a Renal Cell Carcinoma

Study shows no meaningful differences between partial and radical nephrectomy in 5-year rates of local recurrence or cancer-related death.

Aspirin Safe for Partial Nephrectomy Patients

Aspirin Safe for Partial Nephrectomy Patients

Findings among patients on chronic antiplatelet therapy for cardioprotection.

Positive Margins After Partial Nephrectomy Raises Death Risk

Positive Margins After Partial Nephrectomy Raises Death Risk

Positive surgical margins are associated with a significant 34% increased risk of all-cause mortality.

Higher NLR Predicts More Aggressive Kidney Cancer

Higher NLR Predicts More Aggressive Kidney Cancer

Elevated neutrophil-to-lymphocyte ratio is associated with larger tumors and greater nuclear grade.

Partial Nephrectomy Protects Against ESRD

Partial Nephrectomy Protects Against ESRD

Nephron-sparing surgery decreased the risk of end-stage renal disease by 60% in select patients.

Proteinuria Signals Renal Function Decline in Kidney Cancer

Proteinuria Signals Renal Function Decline in Kidney Cancer

Proteinuria is a predictor for renal functional decline in patients with kidney cancer.

Core-Needle Biopsy Aids RCC Diagnosis

Core-Needle Biopsy Aids RCC Diagnosis

Image-guided testing of tissue from the renal mass may lead to improved treatments, researchers say.

Papillary RCC More Common in African Americans

Papillary RCC More Common in African Americans

Racial difference found among patients undergoing robotic partial nephrectomy for renal tumors.

Renal Mass Biopsy for a Small Renal Mass Can Be Accurate

Renal Mass Biopsy for a Small Renal Mass Can Be Accurate

Between renal mass biopsy, surgical pathology, rate of accuracy in identifying malignancies 97.1%.

Prostate Cancer Risk Lower in Type 2 Diabetics

Prostate Cancer Risk Lower in Type 2 Diabetics

In contrast, type 2 diabetes is associated with increased risks of bladder, kidney, liver, and other malignancies.

Robotic Nephrectomy of Kidney Tumors With Thrombi Feasible

Robotic Nephrectomy of Kidney Tumors With Thrombi Feasible

A retrospective study has shown that the procedure is feasible and was performed safely in selected patients with renal tumors.

Researchers Calculate Inherited Cancer Risk from Genes

Researchers Calculate Inherited Cancer Risk from Genes

Estimated 33% of overall risk is genetic; certain types of cancer have additional risk.

NSAIDs May Raise Risk of Fatal Kidney Cancer

NSAIDs May Raise Risk of Fatal Kidney Cancer

Regular use of non-steroidal anti-inflammatory drugs for 10 years or more increased the risk of dying from renal cell carcinoma nearly 4-fold.

Metformin Lowers Death Risk in mRCC Patients on Sunitinib

Metformin Lowers Death Risk in mRCC Patients on Sunitinib

The protective effect was not observed with other anti-diabetic medications.

Nephrectomy as Initial mRCC Treatment Offers Survival Advantage

Nephrectomy as Initial mRCC Treatment Offers Survival Advantage

Patients who underwent upfront cytoreductive nephrectomy lived 6.4 months longer than those treated with upfront targeted therapy, a study found.

Cabozantinib Improves PFS in Patients With Advanced RCC

Cabozantinib Improves PFS in Patients With Advanced RCC

The drug nearly doubled the delay in tumor growth compared with everolimus.

RCC Surgery Outcomes Not Worse in Extremely Obese Patients

RCC Surgery Outcomes Not Worse in Extremely Obese Patients

Study reveals no significant differences in hospital readmission rates and overall, cancer-specific, and recurrence-free survival rates.

FDA Approves New Drug for Advanced Kidney Cancer

FDA Approves New Drug for Advanced Kidney Cancer

Nivolumab is cleared for treating patients with metastatic RCC whose disease advanced despite prior treatment with anti-angiogenic therapy.

Diabetes Predicts Worse Survival in RCC Patients Treated Surgically

Diabetes Predicts Worse Survival in RCC Patients Treated Surgically

For patients with diabetes, poor glycemic control linked to higher risk of post-operative progression.

Type 1, Type 2 Papillary Renal Cell Carcinomas Biologically Distinct

Type 1, Type 2 Papillary Renal Cell Carcinomas Biologically Distinct

Specific alterations seen in type 1 and type 2 carcinomas; type 2 consists of at least 3 subtypes.

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