March 2009 Issue of Renal And Urology News

March 2009 Issue of Renal And Urology News

March 2009

Cover Articles

Hypertension Linked to RCC

Surgery for kidney cancer may help resolve concomitant arterial hypertension, according to a study.

Degree of HLA Mismatch May Not Matter

MARCO ISLAND, Fla.—The transplant community may want to rethink the importance of HLA mismatches when considering live donor kidney transplants, according to new data presented ...

New Strategies to Boost Renal Transplants

MARCO ISLAND, Fla.—Domino paired donation (DPD) and never-ending altruistic donor (NEAD) chains are part of a new spectrum of options for patients with end-stage renal ...

Commentary

The Need for Medical Liability Reform

Two articles in the December 2008 issue of Renal & Urology News add to mounting evidence of the need for medical liability reform, specifically no-fault ...

From Cleveland Clinic

Kidney Transplants in Nonrenal Solid-Organ Transplant Recipients

The number of candidates on the list for kidney transplantation due to end-stage renal disease after a prior nonrenal transplant, particularly liver transplant, is growing ...

Eric A. Klein, MD, Appointed Glickman Institute Chairman

Eric A. Klein, MD, a thought leader in the biology and management of prostate cancer, has been appointed chairman of the Glickman Urological & Kidney ...

After the PSA Cutoff Era: The Importance of Context

About two years ago, having recognized that the prostate-specific antigen (PSA) cutoff level of 4.0 ng/mL did not always assist in accurately categorizing a man's ...

News in Brief

Marijuana Use May Increase Risk of Testicular Cancer

Marijuana use may increase a man's risk of testicular cancer, particularly the nonseminona or mixed-histology form, according to a study published in Cancer (2009; published ...

ED Common in Diabetic Men

Nearly 25% of type 2 diabetic men in the Action for Health in Diabetes study reported having complete erectile dysfunction (ED), according to an article ...

Kidney Removed Through Vagina

Surgeons at Johns Hopkins University in Baltimore successfully removed a healthy donor kidney laparoscopically through a small incision in the back of the donor's vagina.

Hypospadias on the Rise

Researchers have identified a rising prevalence of hypospadias in Danish boys, according to a report in European Urology (2009; published online ahead of print).

Diabetic Foot Linked to GFR

As diabetic patients' renal function decreases, their risk of diabetic foot syndrome (DFS) increases, a study finds.

Adding Tamsulosin Does Not Aid Ureteral Stone Passage

Adding tamsulosin to ibuprofen and oxycodone does not improve outcomes in patients treated for ureteral stones in the emergency department (ED), researchers reported in Annals ...

Feature

Why Use of Home-Based Dialysis Lags

Despite their advantages, peritoneal dialysis and home hemodialysis remain unpopular modalities.

Feature

RRT Modalities Offer Similar AKI Outcomes

Continuous and intermittent renal replacement therapies for patients with acute kidney injury (AKI) are associated with similar outcomes, data show.

World Literature Review

Current Smokers Diagnosed with Bladder Cancer Earlier

Bladder cancer is diagnosed about six years earlier in current smokers than in current nonsmokers, according to Japanese investigators.

Myocardial Perfusion Found to Decline with Hemodialysis

Hemodialysis (HD) is associated with a pronounced drop in myocardial perfusion, a study shows.

Alfuzosin Treatment for BPH Improves Sexual Function

Patients who receive alfuzosin as treatment for benign prostatic hyperplasia (BPH) experience improvements in sexual function as well lower urinary tract symptoms (LUTS), a South ...

FDA News

Topical Gel for Overactive Bladder Approved

Gelnique (oxybutynin chloride) Gel 10%, the first and only topical gel for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, ...

Blood Glucose Monitoring System Approved

The Glucocard 01-mini Blood Glucose Monitoring System from Arkray USA, Inc., of Minneapolis, the only such system that features interchangeable faceplates so users can personalize ...

IND Application for Conjugate to Fight RCC Advances

The FDA has accepted an investigational new drug (IND) application from Medarex, Inc., for MDX-1203, the company's first antibody-drug conjugate (ADC). The ADC is made ...

Safety Review on Cholesterol-Lowering Drugs Updated

The FDA has reaffirmed its position that elevated LDL is a risk factor for heart attack, stroke, and sudden death, among other cardiovascular diseases, and ...

Analgesic Okayed for Relief of Chronic Pain

Labopharm Inc., of Laval, Québec, Canada, has announced that it has received approval for Ryzolt (tramadol HCl extended-release tablets) in a once-daily formulation.

New Drug Cleared For Gout Patients

A new oral medication that reduces serum uric acid levels has received FDA approval for treating hyperuricemia in patients with gout.

Legal Issues

Urologist's Cursory Exam Misses Fournier's Gangrene

Dr. V, 42, opened his own urology practice after several years of working in a large clinic. Now, a year after setting up his own ...

Malpractice News

Report: Most States Protect Apologies

Doctors in 35 states and the District of Columbia can commiserate with patients or their families and worry less about legal repercussions.

Error Rx: Teamwork and Standardized Care

Doctors should give up some of their independence and help develop evidence-based guidelines and protocols if they want to make headway against mistakes, a Johns ...

Insurers Cut Premiums In Several States

Doctors in at least four states are paying less for malpractice insurance than they were a year ago.

Renal Nutrition Update

Food Safety Issues for CKD Patients

Like immunocompromised individuals, CKD patients are especially vulnerable to foodborne illnesses.

Your Money

Health-Care Sector Relatively Stable

Health stocks have long served as defensive holdings—investments that will not collapse in downturns. After all, consumers still buy drugs and visit physicians during recessions. ...

General News

Microalbuminuria Increases CAC Risk

NEW ORLEANS—Microalbuminuria increases both the odds of developing coronary artery calcification (CAC) in patients without symptoms of coronary heart disease and the likelihood of CAC ...

Dialysis Patients At High Altitudes Have Better Survival

Patients who initiate dialysis at high altitude may be at lower death risk compared with those start treatment at low altitude, such as near sea ...

Higher Heart Rate Increases Obesity, Diabetes Risks

Higher heart rates may predispose individuals to the development of obesity and diabetes mellitus, according to a 20-year prospective Japanese study of 614 participants older ...

Very Low-Protein Diets of No Benefit

Very low-protein diets do not delay progression to renal failure in CKD patients any better than low-protein diets and may even increase patients' risk of ...

Observing Renal Masses May Suffice

Observation may be an appropriate management strategy for renal masses in older patients and those with comorbidities, according to investigators.

Calcium May Predict Prostate Cancer Mortality

High serum levels of ionized calcium and total calcium are associated with an elevated risk of dying from prostate cancer, according to findings published in ...

Interdialytic Weight Gain, Mortality Linked

Hemodialysis (HD) patients who experience greater fluid retention between dialyzing sessions are at increased risk of cardiovascular and all-cause mortality, according to researchers.

Megadosage Candesartan Beneficial

Renal disease patients who have persistent proteinuria despite treatment with the highest approved dosage of the angiotensin receptor blocker candesartan may benefit from higher dosages, ...

Glycemic Control May Predict Prostate Cancer Pathology

Hemoglobin A1c (HbA1c) levels prior to radical prostatectomy (RP) may predict tumor aggressiveness in prostate cancer patients with diabetes, Korean researchers reported in The Prostate ...

Age Affects Link Between Erectile Dysfunction, Coronary Artery Disease

Erectile dysfunction (ED) in men aged 40-49 years is associated with a pronounced increase in the risk of future coronary artery disease (CAD), according to ...

Tool IDs Those at Elevated CKD Risk

A new eight-factor algorithm helps predict which patients are most likely to develop CKD within a decade. The model is designed to be used for ...

Nocturnal Hemodialysis Found Not to Improve Quality of Life

Nocturnal hemodialysis (NHD) may not offer a significant improvement in patients' quality of life (QOL) compared with conventional hemodialysis (CHD), according to a new study.

Simultaneous Transplants Boost Odds

MARCO ISLAND, Fla.—Combined liver and kidney transplantation (CLKT) may provide an immunologic benefit compared with first transplanting a liver and then a kidney, according to ...

Protocol Improves ABO-Incompatible Transplants

MARCO ISLAND, Fla.—A brief escalation in immunosuppression without long-term B-cell depletion may provide excellent long-term patient and graft survival after ABO-incompatible (ABOi) kidney transplantation, data ...

Prostate Cancer Death Risk Linked to Vitamin D

Elevated serum levels of vitamin D may be associated with a reduced risk of death from prostate cancer, researchers reported in the British Journal of ...

Dual Therapy Better for RCC Bone Metastases

Radiotherapy plus zoledronate is superior to radiotherapy alone in treating patients with bone metastases from renal cell carcinoma (RCC), new findings suggest.

Drug Eases Post-Nephrolithotomy Pain

Preoperative IV infusion of pentoxifylline (PTX) may help to reduce pain intensity and inflammatory changes in patients undergoing nephrolithotomy, data suggest.

Intrarenal Infusions Aid AKI Recovery

HOLLYWOOD, Fla.— Using a novel drug-delivery system to infuse fenoldopam and other vasodilators directly into the kidneys may improve recovery from acute kidney injury (AKI), ...

Hyperoxaluria After Bariatric Surgery

Patients with no history of kidney stones have a high prevalence of hyperoxaluria following bariatric surgery, researchers reported in The Journal of Urology (2009;181:161-166).

Chewing Gum Aids Phosphate Control

Adding salivary phosphate-binding chewing gum to traditional phosphate-binder therapy could improve hyperphosphatemia control in hemodialysis (HD) patients, data show.

Unilateral PCa Difficult to Predict

Biopsy findings of unilateral prostate cancer are unreliable for identifying candidates for hemi-ablative focal therapy, according to researchers.

Drugs Benefit Patients with Heart and Renal Failure

NEW ORLEANS—Most heart failure patients with renal failure can be managed successfully with ACE inhibitors or angiotensin receptor blockers (ARBs), and the treatment is associated ...

Drug Raises Serum Albumin

Megestrol acetate (MA) may safely increase serum albumin in malnourished dialysis patients, according to researchers in Iran.

GreenLight Laser Effective for LUTS

SHANGHAI—Laser vaporization of prostate tissue using a 120-watt GreenLight laser significantly reduces lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH), according to ...

Review articles

Obesity in CKD: Is It Friend or Foe?

In a seemingly paradoxical manner, observational studies examining outcomes in patients suffering from CKD have found significantly altered risk-factor patterns such that conventional mortality risk ...

A Case for Calcium-Based Binders

This article is the second in a series on hyperphosphatemia management in CKD patients.

Renal Function Following Nephrectomy

Protection of renal function is a primary concern of physicians who manage surgical or medical diseases of the kidney, such as renal tumors, urinary calculi, ...

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