February 2016 Issue of Renal And Urology News

February 2016 Issue of Renal And Urology News

Renal & Urology News Jan-Feb 2016 Issue

Nephrology Cover Articles

Current eGFR Better for ESRD Prediction

It has a stronger association with future end-stage renal disease risk than past eGFR decline, large study shows.

Some Discarded Higher-Risk Kidneys May Be Transplantable

Just over half of kidneys from deceased ECD/DCD donors are not used, study finds.

Kidney Damage Linked to Prediabetes

In a prospective study, prediabetes was an independent risk factor for hyperfiltration and increased albuminuria.

Urology Cover Articles

Aspirin May Reduce Risk of Lethal Prostate Cancer

In large observational study, regular use—defined as 3 tablets per week—was associated with a 24% lower risk of dying from prostate cancer.

Nephrectomy as Initial mRCC Treatment Offers Survival Advantage

Patients who underwent upfront cytoreductive nephrectomy lived 6.4 months longer than those treated with upfront targeted therapy, a study found.

Flavonoid-Rich Foods May Lower Erectile Dysfunction Risk

A combination of exercise and a flavonoid-rich diet can reduce the risk of erectile dysfunction by 21%.


Adjuvant Therapies: Time to Fold or Double Down?

Benjamin T Ristau, MD, and Robert G. Uzzo, MD, FACS, examine why adjuvant therapies have been so ineffective.

News in Brief

Hyperkalemia-Diabetes Link Found in CKD Patients

Among patients with stage 3 chronic kidney disease, hyperkalemia prevalence is significantly higher among diabetic than non-diabetics.

RCC Surgery Outcomes Not Worse in Extremely Obese Patients

Study reveals no significant differences in hospital readmission rates and overall, cancer-specific, and recurrence-free survival rates.

Hypospadias Prevalence Found to Vary Widely

True prevalence of hypospadias and related trends are difficult to estimate.

Statin Use May Raise Kidney Disease Risk

Statin users had 30% increased odds of acute kidney injury and 36% increased odds of chronic kidney disease compared with non-users.

PAE Effect on Prostate Zones Characterized

Prostatic arterial embolization significantly reduced volumes of median lobes, central zones, peripheral zones, and whole prostate glands.

Study Supports Use of SWL for Moderate-Sized Stones

SWL treatment success rate was 70.4% and 53.1% for stones less than 15 mm and 15 mm or larger, respectively.

Practice Management

How to Use Dialysis Center Ratings

At the highest level, the ratings can be used to categorize facilities. They can also indicate which facilities may need more resources.

General News

Specialized Immunonutrition May Benefit Radical Cystectomy Patients

In a pilot study, an arginine-enriched drink improved postoperative immune response and infection rate.

Newer Anticoagulants Safer for CKD Patients

Meta-analysis reveals a lower risk of bleeding and arterial thromboembolism compared with conventional agents.

Weekly ESA Dosing at Dialysis Centers May Offer Time Savings

The estimated potential staff time savings totaled 23 hours for an average facility with 70 patients, researchers found.

Greater Plant Protein Intake May Lower Death Risk in CKD Patients

The death risk decreases 23% with each 33% increase in plant protein to total protein ratio, study finds.

Clinical Prostatitis May Lower Prostate Cancer Risk in Black Men

In white men, the condition is associated with an increased risk of prostate cancer only in the absence of histologic inflammation.

No Increased Bleeding Risk With Warfarin in CKD Patients

Direct oral anticoagulants were superior to dose-adjusted warfarin, however, reducing the risk of major bleeding by 19% in patients with mild to moderate renal impairment.

Racial/Ethnic Disparities in Home Dialysis Outcomes Identified

Blacks undergoing PD or home HD and Hispanics undergoing PD are less likely than their white counterparts to receive a kidney transplant.

Post-Cystectomy Complications Linked to Poor Mental Health

Lower patient-reported mental health was statistically associated with an increased incidence of high-grade complications after radical cystectomy.

Long-Term Cardiovascular Mortality Linked to Post-Op AKI, CKD

Even surgery patients with stage 1 AKI without true organ damage had a 43% increase in cardiovascular mortality risk within 10 years compared with patients ...

Larger Prostates Predict Higher Risk of Lower Urinary Tract Symptoms

The risk is 67% higher in men with a prostate size of 40.1-80 mL than those with smaller glands.

CKD Risk Following Inpatient Acute Kidney Injury Characterized

Even mild AKI with rapid recovery is associated with increased risk of chronic kidney disease stage 3 or higher.

Bipolar Androgen Therapy Promising for Advanced Hormone-Sensitive PCa

In a small study, high-dose testosterone given intermittently with androgen deprivation therapy lowered PSA levels without serious adverse effects.

Statins May Prolong Abiraterone Treatment Duration

Researchers observed a trend toward longer time on drug among men with castration-resistant prostate cancer.

Study: 5-ARIs Lower Prostate Cancer Progression Risk

Non-users of 5-alpha-reductase inhibitors had a nearly 2.6 times increased risk of pathologic progression than those who took the drugs.

Healthy Lifestyle After PCa Diagnosis Beneficial

Through diet and exercise, prostate cancer patients can decrease their risk of dying from their illness.

NSAIDs May Raise Risk of Fatal Kidney Cancer

Regular use of non-steroidal anti-inflammatory drugs for 10 years or more increased the risk of dying from renal cell carcinoma nearly 4-fold.

Any Renal Function Decline in Living Kidney Donors a Cardiac Risk

Increased left ventricular mass found in donors with even mild decreases in renal function.

VUR-Related Renal Scarring Characterized

Older age and a second episode of urinary tract infection identified as risk factors.

AKI Diagnostic Testing May Be Excessive

Results of some urine and blood tests are unlikely to affect diagnosis or management of acute kidney injury.

Enzalutamide More Effective than Bicalutamide in mCRPC Patients

Enzalutamide reduced the risk of disease progression by 56% in mCRPC patients.

Caution Urged In the Use of Megestrol

Use of oral megestrol acetate (MA) is associate with significant adverse effects.

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