December 2016 Issue of Renal And Urology News

December 2016 Issue of Renal And Urology News

Renal & Urology News Nov-Dec 2016 Issue

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Nephrology Cover Articles

Calciphylaxis Risk Higher in Peritoneal Dialysis Patients

Their risk of the rare but life-threatening condition is twice as high as in hemodialysis patients.

Novel Drug Shows Promise for FSGS

Sparsentan could become the first FDA-approved medication for the focal segmental glomerularsclerosis.

Urology Cover Articles

Therapeutic Sequences for mCRPC Probed

Researchers demonstrate a possible survival advantage by including cabazitaxel in sequences of new agents in the post-docetaxel setting.

New Prostate Cancer Screening Algorithm Proposed

A PSA level of 1.5 ng/mL or higher should prompt primary care physicians to refer patients to a urologist for further evaluation.

Hyponatremia Identified as Kidney Stone Risk Factor

Studies also link kidney stone development to osteoporosis and proton pump inhibitor use.

News in Brief

SHPT Surgical Procedures Equally Effective

Randomized study compared total parathyroidectomy with and without autotransplantation.

FDA Approves Removal of Boxed Warning for Hyperkalemia Drug

Updated label for patiromer now recommends the drug be taken at least 3 hours before or after other oral medications.

Study: Older Age Should Not Preclude Partial Nephrectomy

Partial and radical nephrectomy were associated with similar cancer-specific and overall survival in elderly patients.

Higher Testosterone Levels May Hike Renal Stone Risk

Mean levels of total serum testosterone and serum dihydrotestosterone were significantly higher in urolithiasis cases compared with controls.

Chronic Periodontitis Increases ED Risk

Chronic periodontitis was associated with 2.2-fold increased odds of ED.

Urinary Cancer Risk Lower in Spironolactone Users

Spironolactone use was associated with 12% decreased odds of prostate cancer in male patients and 19% decreased odds of bladder cancer in female patients.

Editor's Letter

RCC Adjuvant Therapy: Calculating Value

Adjuvant treatments for RCC must be prioritized by physicians because ultimately value is determined by how medicine is practiced.

Practice Management

How to Deal With Negative Doctor Reviews

Managing complaints can be a way to make or break your patient relationships and online reputation.

General News

Racial Disparities Found in Prostate Cancer Treatment

Within each D'Amico risk category, African-American and Hispanic prostate cancer patients were less likely to receive definitive treatment than white patients.

Kidney Donors Possibly at Risk for Bone Loss

Bone turnover markers increased following unilateral nephrectomy.

Smoking Ups Morbidity, Mortality in CKD, But Not ESRD Risk

Current smoking was linked with higher risks for lung cancer and upper aerodigestive cancer by 9 and 5 times, respectively.

Cabozantinib Superior as Front-Line Therapy for Advanced RCC

Use of the drug is associated with significantly longer progression-free survival compared with suninitib in treatment-naïve patients.

ALP Decline in Radium-223 Recipients Predicts Better Outcomes

In a study, a drop in alkaline phosphatase level at 12 weeks compared with baseline was associated with a decreased risk of death and first ...

Nivolumab Shows Promise for Metastatic Urothelial Cancer

Based on a small study, investigators report encouraging efficacy and safety.

Obesity Linked With Prostate Cancer Death

A body mass index of 30 kg/m2 or higher was was associated with 2-fold increased risk of dying from prostate cancer.

Intensive Hemodialysis Effective for Treating Hyperphosphatemia

It can sharply lower serum phosphorus levels and reduce dependence on phosphate binders.

FDA Adds Abuse Warning to All Testosterone Products

The new FDA warning alerts prescribers to the abuse potential of testosterone.

Hypogonadism Ups Progression Risk in Men With Low-Risk PCa

New findings have potential implications regarding patient selection for active surveillance.

Fewer Physicians Starting Nephrology Fellowship Training

Researchers document an 8% dip in 2015-2016 compared with the previous academic year.

Uric Acid-Lowering Benefit of Lesinurad Confirmed

Benefit of adding the uricosuric drug to a xanthine oxidase inhibitor persists for up to 2 years, extension study shows.

Hyperkalemia Increases Death Risk

Death risk increased markedly once serum potassium values exceeded 5.5 mEq/L.

Microalbuminuria On the Rise Among Healthy Obese Individuals

From 2001 to 2014, the prevalence of microalbuminuria among obese individuals without other comorbidities increased from 3.2% to 8.1%.

Study Reveals Vitamin D Therapy Effect on Mineral Biomarkers

Calcitriol and paricalcitol raise levels of fibroblast growth factor 23 and sclerostin and lower levels of some bone turnover markers.

Blood Pressure Reductions With Patiromer Possibly Explained

Evidence suggests decreased sodium absorption could be a contributing factor in at least some patients.

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

Odds of acute kidney injury increases by 29% with each 1 mg/dL increment in uric acid level at ICU admission.

Omega-3 Fatty Acids May Explain Hemodialysis Obesity Paradox

Study reveals a link between higher BMI in HD patients and greater incorporation of omega-3 fatty acids into red blood cell membranes.

Urea May Offer Cheaper Option for Long-Term SIADH Treatment

Researchers present results from the first long-term study of Urea USP in the United States.

Hypo- , Hyperkalemia Linked to ESRD

The risks of death from any cause were elevated by 22% and 31% for individuals with serum potassium levels of 5.5 mmol/L and 3.2 mmol/L, ...

Optimal Vitamin C Dose for Anemia in Hemodialysis Patients Unclear

Pending future research, patients should avoid taking more than 120 mg per day.

Early RRT for AKI May Lower Risk of Dialysis Dependence

It also may shorten intensive care unit and hospital length of stay versus late RRT in critically ill patients, meta-analysis reveals.

Severe AKI in Young ICU Patients Predicts Higher Mortality

The condition also is associated with greater use of renal-replacement therapy and mechanical ventilation.

Prostate Cancer Incidence Lower in HIV-Infected Men

HIV-infected men and women had lower incidences of colorectal and lung cancer compared with the general population.

Alpha Blockers Aid Passage of Large Ureteric Stones

For every 1 mm increase in stone size, the odds of passage increased by 9.8%.

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