California researchers have found that low testosterone levels occur five times more often among men taking long-acting opioids.
Many physicians remain wary about starting testosterone replacement therapy (TRT) in hypogonadal men in large part out of concern that it could cause progression of undiagnosed prostate cancer (PCa) or promote PCa development.
A history of prostate cancer has generally been a contraindication for testosterone therapy, but the clinical model may be changing.
Researchers studied 850 testosterone-deficient men who received 1,000 mg parenteral testosterone undecanoate six weeks after baseline and then every 12 weeks for up to five years.
Hypogonadal men aged 65 years and older experience significant benefit from TRT over 12 months.
In men taking daily opioids, duration of action, but not dose, affects risk of hypogonadism
Researchers reviewed clinical trial and postmarketing data.
Adding testosterone therapy to sildenafil is not more effective in treating erectile dysfunction (ED) than sildenafil alone,
Sildenafil plus testosterone not superior for men with erectile dysfunction, low testosterone.
Researchers predict about 1.3 million new cases of cardiovascular disease related to low testosterone over a 20-year period.
Long-term treatment found not to increase the incidence of prostate cancer.
Finding was based on a study of 1,365 men with symptomatic androgen deficiency.
Measures that led to weight loss found to raise levels significantly in overweight, prediabetic men.
Treatment is associated with weight loss and improvements in components of metabolic syndrome.
Study implicates factors other than aging, including weight gain, smoking cessation, depression and cardiovascular disease.
One case of cancer diagnosed per 212 years of testosterone replacement therapy
The FDA has approved two lower-dose formulations for Androderm, a once-daily transdermal patch for men with low testosterone.
ORLANDO, Fla.—Testosterone supplementation in elderly men with borderline low testosterone levels may not improve erectile dysfunction (ED) compared with placebo, new findings suggest.