Hypogonadal Men with ED May Benefit from Testosterone Plus Vardenafil

Combination therapy with testosterone and vardenafil is safe and effective in treating hypogonadal men with erectile dysfunction (ED) and who failed to respond to testosterone monotherapy, according to researchers.

In a prospective study, 129 testosterone deficient men (serum total testosterone 3.4 ng/mL or less) received intramuscular injections of long-acting parenteral testosterone undecanoate at three-month intervals. The mean follow-up was eight months. Of the 129 men, 71 (58.2%) responded well to monotherapy within three months.

According to the investigators, non-responders had lower testosterone levels and higher rates of concomitant diseases and smoking. Among the non-responders, 34 accepted the addition of 20 mg vardenafil on demand. Thirty of 34 patients responded well to this combination, Dany-Jan Yassin, MBBS, of Klinikum Braunschweig, Braunschweig, Germany, and colleagues reported online ahead of print in the Journal of Sexual Medicine. The score on the International Index of Erectile Function-Erectile Function domain improved significantly from 12 to 24, and partner survey showed significantly higher satisfaction. “These patients reported spontaneous or nocturnal and morning erections or tumescence,” the researchers noted.

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