Hypogonadism News Archive

Low Testosterone Tied to Anemia Risk in Men With Type 2 Diabetes

Low Testosterone Tied to Anemia Risk in Men With Type 2 Diabetes

In type 2 diabetic male patients, a low testosterone level was found to be associated with anemia. These findings are consistent with previous reports.

Testosterone Replacement May Delay CKD Progression

Testosterone Replacement May Delay CKD Progression

Study demonstrates decreased risk of end-stage renal disease and all-cause mortality.

TRT Does Not Appear to Increase PCa Risk

TRT Does Not Appear to Increase PCa Risk

A population-based study showed no association between total prostate cancer risk and testosterone replacement therapy (TRT).

Testosterone Therapy Does Not Improve Cognitive Function

Testosterone Therapy Does Not Improve Cognitive Function

Study of older hypogonadal men does not support use of TRT to improve memory, according to researchers.

Anemia, Bone Density Improve With Testosterone Replacement

Anemia, Bone Density Improve With Testosterone Replacement

Older men on TRT versus placebo for 1 year had improved hemoglobin levels and volumetric bone mineral density and estimated bone strength.

Testosterone Replacement May Lower Cardiovascular Risks

Testosterone Replacement May Lower Cardiovascular Risks

In a large study, testosterone replacement therapy was associated with a 33% lower risk of cardiac and stroke events among hypogonadal men.

Normal Testosterone Range Defined

Normal Testosterone Range Defined

The normal range for total testosterone is 264 to 916 ng/dL for healthy men ages 19 to 39 with a body mass index below 30 kg/m2.

Venous Thromboembolism Risk Up in TRT Initiators

Venous Thromboembolism Risk Up in TRT Initiators

Risk peaks in the first 6 months of hormone treatment, but overall odds are low.

2 Percent Daily Testosterone Shows 6-Month Efficacy

2 Percent Daily Testosterone Shows 6-Month Efficacy

Once-daily T-sol administered for 6 months did not indicate new safety concerns, and the outcomes of low sex drive and low energy showed further improvement.

Hypogonadism Ups Progression Risk in Men With Low-Risk PCa

Hypogonadism Ups Progression Risk in Men With Low-Risk PCa

New findings have potential implications regarding patient selection for active surveillance.

FDA Adds Abuse Warning to All Testosterone Products

FDA Adds Abuse Warning to All Testosterone Products

The new FDA warning alerts prescribers to the abuse potential of testosterone.

FDA Adds New Testosterone Warnings

FDA Adds New Testosterone Warnings

Labeling changes will alert prescribers to the abuse potential of testosterone and the serious adverse effects.

TRT May Improve Cognition in Younger Hypogonadal Men

TRT May Improve Cognition in Younger Hypogonadal Men

Young men reported improvement in executive function after 2 years of TRT.

Study: mpMRI Findings in Prostate Cancer Patients Unaffected by TRT

Study: mpMRI Findings in Prostate Cancer Patients Unaffected by TRT

Results show that mpMRI and PI-RADSv2 score have a greater ability to detect prostate cancer progression after TRT compared with PSA.

Hypogonadism in Male HD Patients Linked to Poor ESA Response

Hypogonadism in Male HD Patients Linked to Poor ESA Response

Other risk factors include reduced muscle mass and lower levels of physical activity.

Testosterone Solution Effective for Hypogonadism Over 9 Months

Testosterone Solution Effective for Hypogonadism Over 9 Months

Once-daily 2% testosterone solution safe and effective for sex drive and energy.

Erectile Dysfunction Predicts Higher Risk of Osteoporosis

Erectile Dysfunction Predicts Higher Risk of Osteoporosis

Low testosterone levels may be a contributing factor.

Testosterone Treatment Aids Sexual Function of Older Men

Testosterone Treatment Aids Sexual Function of Older Men

Gel hormone treatment led to improved libido, increased sexual activity.

Testosterone Replacement Safe for Men With Prostate Cancer

Testosterone Replacement Safe for Men With Prostate Cancer

Findings emerge from a study of hypogonadal men who underwent radiation therapy, surgery, or active surveillance for prostate cancer.

Testosterone Therapy for Severe Hypogonadism Improves Sexual Function

Testosterone Therapy for Severe Hypogonadism Improves Sexual Function

The finding is from a 30-week study comparing testosterone undecanoate and placebo in hypogonadal men with type 2 diabetes.

Anabolic Steroids Easily Obtained Without Rx

Anabolic Steroids Easily Obtained Without Rx

Alert patients that use of performance-enhancing drugs can lead to erectile dysfunction and infertility.

Novel Oral Testosterone Shows Long-Term Safety, Tolerability

Novel Oral Testosterone Shows Long-Term Safety, Tolerability

In particular, no hepatic toxicities emerged during a 52-week phase 3 trial.

Prostate Cancer Risk Not Increased With Testosterone Therapy

Prostate Cancer Risk Not Increased With Testosterone Therapy

In fact, some data suggest treatment may reduce prostate cancer incidence and aggressiveness.

TRT Found to Reduce Anemia in Hypogonadal Men

TRT Found to Reduce Anemia in Hypogonadal Men

After 54 weeks of treatment with testosterone undecanoate, anemia prevalence decreased from 29.6% to 10%.

Low Testosterone Associated with Higher Death Risk in Male Dialysis Patients

Low Testosterone Associated with Higher Death Risk in Male Dialysis Patients

Study also identifies clinical characteristics associated with testosterone deficiency in this population.

Topical Testosterone Restorative for Hypogonadal Men

Topical Testosterone Restorative for Hypogonadal Men

73% of men in the testosterone group showed improvement in sexual arousal, interest, and drive.

Testosterone Modestly Improves Sexual Function in Older Men

Testosterone Modestly Improves Sexual Function in Older Men

Larger studies and long-term follow-up needed to determine possible risks of treatment.

Cinacalcet for SHPT May Lower Testosterone

Cinacalcet for SHPT May Lower Testosterone

Serum total and free testosterone declined in men on hemodialysis who received a 6-month course of the drug for secondary hyperparathyroidism.

Opioid Use Linked to Low Testosterone

Opioid Use Linked to Low Testosterone

Increased odds of low testosterone with opioid exposure; increased odds with increasing age, comorbidities.

Low Testosterone Before ADT Predicts Poor Prognosis in Metastatic PCa

Low Testosterone Before ADT Predicts Poor Prognosis in Metastatic PCa

The study found no association with obesity, however, unlike previous studies.

Testosterone Therapy Does Not Appear to Worsen LUTS/BPH

Testosterone Therapy Does Not Appear to Worsen LUTS/BPH

A recent review found little evidence to support severe lower urinary tract symptoms as a contraindication to TRT.

Androgen Deprivation Therapy Linked to Alzheimer's Disease

Androgen Deprivation Therapy Linked to Alzheimer's Disease

A new study by University of Pennsylvania and Stanford researchers highlights a possible link between men who receive androgen deprivation therapy (ADT) and the future onset of Alzheimer's disease.

Testosterone Therapy Possibly Increases Insulin Sensitivity

Testosterone Therapy Possibly Increases Insulin Sensitivity

Increased insulin sensitivity in men with type 2 diabetes and hypogonadotropic hypogonadism.

Endocrinologist Groups Reject FDA's Testosterone Therapy Position

Endocrinologist Groups Reject FDA's Testosterone Therapy Position

Signs and symptoms and testosterone levels, not the presence of disorders that cause low testosterone, should guide treatment decisions.

Why Heart Safety of Testosterone in Older Men Remains a Concern

Why Heart Safety of Testosterone in Older Men Remains a Concern

Most men prescribed testosterone have age-related hypogonadism, for which treatment is not FDA-approved

Testosterone Therapy Has No Effect on Atherosclerosis Progression

Testosterone Therapy Has No Effect on Atherosclerosis Progression

Use of testosterone gel for 3 years did not alter the rate of change in carotid intima-media thickness or coronary artery calcium.

Normalized Testosterone Levels Linked to Fewer Heart Attacks, Strokes

Normalized Testosterone Levels Linked to Fewer Heart Attacks, Strokes

Men with normalized testosterone levels following TRT had significantly lower risks of heart attacks and strokes, study finds.

High-Grade Prostate Cancer Linked to Low Testosterone

High-Grade Prostate Cancer Linked to Low Testosterone

Hypogonadal men are more likely than those with normal testosterone to have prostate biopsy results showing high-grade PCa.

Some Hypogonadism Guidelines Need Updating, Review Finds

Some Hypogonadism Guidelines Need Updating, Review Finds

Quality studies are still needed to answer crucial questions about TRT and prostate cancer, cardiovascular risk.

Testosterone Therapy Not Associated With VTE

Testosterone Therapy Not Associated With VTE

Finding based on data from more than 30,000 American men, 40 and older.

Topical Testosterone Doesn't Improve Ejaculatory Dysfunction

Topical Testosterone Doesn't Improve Ejaculatory Dysfunction

Researchers saw no improvement for patients with low testosterone and delayed ejaculation.

Screen for Depression in Men With Borderline Testosterone

Screen for Depression in Men With Borderline Testosterone

More than half of men with borderline testosterone have depressive symptoms -- a higher rate than the general population; 25% are taking antidepressants.

Statins Decrease Aggression in Men

Statins Decrease Aggression in Men

Statins generally decrease aggression in men, increase aggression in postmenopausal women.

Testosterone Fenofibrate Combo Best Protects Hypogonadal Men's Hearts

Testosterone Fenofibrate Combo Best Protects Hypogonadal Men's Hearts

Findings in older men with high cholesterol and low testosterone.

Testosterone Therapy Safe in Hypogonadal Elderly Men

Testosterone Therapy Safe in Hypogonadal Elderly Men

In a study of hypogonadal men older than 65, the treatment did not increase the prevalence of thrombotic events.

Testosterone Therapy May Benefit Hypogonadal CP/CPSS Sufferers

Testosterone Therapy May Benefit Hypogonadal CP/CPSS Sufferers

Patients experienced significant improvements in symptoms and quality of life parameters.

Testosterone Replacement Use Low Among Hypogonadal Men

Testosterone Replacement Use Low Among Hypogonadal Men

Hypogonadism was present in 42.8% of subjects, yet TRT was used by only 3.9%.

Testosterone Therapy Seldom Used in Hypogonadal Men

Testosterone Therapy Seldom Used in Hypogonadal Men

Researchers also found that clinicians prescribed testosterone replacement therapy to men of reproductive age despite the risks.

Sex Hormones Predict Erectile Dysfunction Risk

Sex Hormones Predict Erectile Dysfunction Risk

High levels of free and bioavailable testosterone are associated with a significantly decreased risk of ED in younger men.

Can Declining Sexual Desire Cause Lower Testosterone?

Can Declining Sexual Desire Cause Lower Testosterone?

Lower testosterone levels linked to decreased sexual activity and desire, but not to fewer erections.

Depression Prevalent in Borderline Testosterone Patients

Depression Prevalent in Borderline Testosterone Patients

In this study, over half the men referred for borderline testosterone levels had depression.

Hypogonadal Symptoms in Younger Men May Begin at Higher Threshold

Hypogonadal Symptoms in Younger Men May Begin at Higher Threshold

Among men younger than age 40, a total testosterone level of less than 400 ng/dL was linked with hypogonadal symptoms.

No Cardiovascular Risks with Testosterone Therapy

No Cardiovascular Risks with Testosterone Therapy

New data from two studies indicate that testosterone therapy is not associated with cardiovascular risks, which challenges recent FDA decisions.

Testosterone Found to Boost Efficacy of PDE5 Inhibitors

Testosterone Found to Boost Efficacy of PDE5 Inhibitors

The authors recommend consideration of testosterone assays in men who fail to respond to PDE5 inhibitors in an effort to optimize outcomes.

Testosterone Nasal Gel Effective for Hypogonadism, Low Side Effects

Testosterone Nasal Gel Effective for Hypogonadism, Low Side Effects

Three doses of testosterone nasal gel may help normalize testosterone levels in men with hypogonadism.

FDA Adds CVD Warning to Testosterone Replacement

FDA Adds CVD Warning to Testosterone Replacement

Prescription testosterone product labels must now include warnings about the possible increased risk of heart attacks and strokes, says FDA.

Sulfonylurea Increases Testosterone in Diabetic Men

Sulfonylurea Increases Testosterone in Diabetic Men

Researchers observed increases in total testosterone levels, testosterone secretion index values in middle-aged men with type 2 diabetes.

Low Testosterone Linked to Adverse Outcomes in T2DM

Low Testosterone Linked to Adverse Outcomes in T2DM

Review shows inverse links between testosterone level and aging, metabolic syndrome, CVD

Testosterone Therapy Does Not Increase PCa Risk in Hypogonadal Men

Testosterone Therapy Does Not Increase PCa Risk in Hypogonadal Men

Long-term testosterone therapy in hypogonadal men is safe, an observational study suggests. New cases of prostate cancer were lower than expected.

Study Correlates Testosterone Levels with Symptoms

Study Correlates Testosterone Levels with Symptoms

Investigators evaluated the correlation between hypogonadal symptoms and serum testosterone levels using ADAM questionnaire.

Rate of Testosterone Testing on the Rise

Rate of Testosterone Testing on the Rise

Increased likelihood of testing in men with comorbidity associated with hypogonadism.

Testosterone Therapy Does Not Increase Cardiovascular Risk

Testosterone Therapy Does Not Increase Cardiovascular Risk

Testosterone replacement therapy (TRT) does not increase cardiovascular disease (CVD) risk.

Rising PSA with Testosterone Gel Linked with Specific Factors

Rising PSA with Testosterone Gel Linked with Specific Factors

Greater PSA increases seen in older men and those with lower baseline testosterone.

Testosterone Replacement Therapy (TRT) Beneficial in Diabetes Mellitus Patients

Testosterone Replacement Therapy (TRT) Beneficial in Diabetes Mellitus Patients

Testosterone replacement therapy (TRT) may lower hemoglobin levels and improve lipid profile in diabetic men with androgen deficiency.

Low Testosterone Raises Atherosclerosis Risk in Diabetic Men

Low Testosterone Raises Atherosclerosis Risk in Diabetic Men

Low total testosterone was associated with increased odds of greater carotid intima-media thickness and odds of endothelial dysfunction.

Testosterone Replacement Therapy (TRT) May Promote Prostate Tumor Growth

Testosterone Replacement Therapy (TRT) May Promote Prostate Tumor Growth

Testosterone replacement therapy (TRT) may promote prostate cancer tumor growth.

Low Testosterone Raises Atherosclerosis Risk in Diabetics

Low Testosterone Raises Atherosclerosis Risk in Diabetics

Low testosterone may increase cardiovascular (CV) risk in middle-aged men with type 2 diabetes.

Testosterone Therapy Does Not Raise Heart Attack Risk

Testosterone Therapy Does Not Raise Heart Attack Risk

Testosterone therapy for men who produce little to no hormones does not increase heart attack risk.

Erectile Dysfunction (ED) in Middle-Aged Men Linked to Depression

Erectile Dysfunction (ED) in Middle-Aged Men Linked to Depression

When it comes to erectile dysfunction (ED) in middle-aged men, testosterone may not be a key factor.

FDA Panel: Limit Testosterone Drug Use

FDA Panel: Limit Testosterone Drug Use

Joint committee also calls for drug makers to run heart-risk tests on popular 'Low T' products.

Insufficient Data on Benefits, Risks of Testosterone Drugs

Insufficient Data on Benefits, Risks of Testosterone Drugs

Expert panel to decide whether prescribing information on testosterone drugs should be changed.

Common Chemicals Lower Testosterone

Common Chemicals Lower Testosterone

Chemicals found in many household products may reduce androgen levels in both sexes.

Obesity Diminishes Sexual Function in Young Men

Obesity Diminishes Sexual Function in Young Men

Obesity can lead to a deterioration of erectile function in young men.

Testosterone Supplements Not Linked to Heart Attacks

Testosterone Supplements Not Linked to Heart Attacks

Finding runs counter to some prior reports; much larger trials are needed, experts say.

Topical Testosterone Gel Approved

Topical Testosterone Gel Approved

In a study, 74% of men treated with Vogelxo achieved normal testosterone levels within 90 days.

Long-Term Testosterone Therapy Does Not Raise PCa Risk

Long-Term Testosterone Therapy Does Not Raise PCa Risk

Researchers report findings from a study of 942 hypogonadal men treated at 3 German centers.

Female Intuition and Testosterone

Female Intuition and Testosterone

Exposure to prenatal testosterone accounts for many of the differences between men and women, particularly in the brain.

FDA Clears First Nasal Testosterone Therapy

FDA Clears First Nasal Testosterone Therapy

The product is self-administered via a nasal applicator.

Erectile, Ejaculatory Dysfunction More Common in Cardiac Patients

Erectile, Ejaculatory Dysfunction More Common in Cardiac Patients

Study also shows a 6-fold higher rate of hypogonadism compared with the general population.

Testosterone Therapy Does Not Improve Glucose Metabolism

Testosterone Therapy Does Not Improve Glucose Metabolism

For men with T2DM and low testosterone, tx also doesn't improve visceral adiposity.

Low Testosterone May Signal Need for PCa Reclassification

Low Testosterone May Signal Need for PCa Reclassification

Drop in testosterone levels in patients on active surveillance may predict need for treatment.

New Tool May Aid Screening for Low Testosterone

New Tool May Aid Screening for Low Testosterone

Weight, frequent exercise, and adult-onset diabetes are among the risk factors for hypogonadism.

Hypogonadism May Raise Death Risk in Men with CKD

Hypogonadism May Raise Death Risk in Men with CKD

Patients in the second lowest quintile of testosterone level had a 53% increased death risk compared with those in the highest quintile.

Long-Term TRT Leads to Progressive Weight Loss, Other Benefits

Long-Term TRT Leads to Progressive Weight Loss, Other Benefits

Parenteral testosterone undecanoate over 5 years found to decrease waist circumference and improve components of metabolic syndrome.

High Estradiol Boosts Libido in Men on Testosterone Therapy

High Estradiol Boosts Libido in Men on Testosterone Therapy

Elevated serum estradiol is associated with increased libido in men receiving TST.

Early AM Best for Measuring Testosterone in Younger Men with ED

Early AM Best for Measuring Testosterone in Younger Men with ED

In men aged 44 years or less, total testosterone levels drop off significantly after 9 AM, study shows.

Testosterone Therapy Raises Myocardial Infarction Risk

Testosterone Therapy Raises Myocardial Infarction Risk

Risk is higher in younger men with pre-existing heart disease and in older men.

FDA to Review Testosterone Therapy Safety

FDA to Review Testosterone Therapy Safety

Agency pointed to recent studies citing possible heightened heart risk tied to the treatments.

Low Testosterone May Predict Worse Prostate Cancer Outcomes

Low Testosterone May Predict Worse Prostate Cancer Outcomes

Preoperative levels below 300 ng/dL are associated with an increased risk of positive surgical margins and seminal vesicle invasion.

Testosterone Therapy May Be Safe for Prostate Cancer Patients

Testosterone Therapy May Be Safe for Prostate Cancer Patients

In fact, a study showed that testosterone replacement is associated with a decreased risk of cancer-specific and overall mortality.

Testosterone Often Initiated in Men With Normal Levels

Testosterone Often Initiated in Men With Normal Levels

Dramatic increase in testing and supplementation occurred in the last decade in the United States.

Testosterone May Weaken Vaccine Response

New findings could help explain why women generally respond immunologically to vaccines more strongly than men.

Testosterone May Ease Inflammatory Bowel Disease in Hypogonadal Men

Testosterone May Ease Inflammatory Bowel Disease in Hypogonadal Men

Long-term treatment led to a decrease in Crohn's Disease Activity Index and high-sensitivity C-reactive protein.

TRT Doesn't Worsen Urinary Tract Symptoms

TRT Doesn't Worsen Urinary Tract Symptoms

About 30 percent of men experience an AUA symptoms index improvement of 3 or more points.

Optimal Testosterone Levels Predict Better Survival in Older Men

Midrange levels of total testosterone and dihydrotestosterone are associated with decreased all-cause mortality.

Hypogonadal Men with ED May Benefit from Testosterone Plus Vardenafil

The drug combination was associated with significantly improved erectile function and partner satisfaction in men who did not respond to testosterone alone.

TSPO Not Needed for Testosterone Production After All

Improved understanding of biosynthesis mechanisms will lead to better diagnoses and treatments for steroid hormone production disorders.

Testosterone Therapy May Raise Cardiovascular Risk

In a study, it was associated with a 29% increased risk of death and/or heart attack or stroke.

Role of Testosterone in Heart Risk Unclear

Men with low testosterone levels may be at slightly increased risk of developing or dying from cardiovascular disease.

Hypogonadal Men with BPH Benefit from Dutasteride

Improvements observed in urinary symptoms and bone mineral density.

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