Rate of Testosterone Testing on the Rise

Rate of Testosterone Testing on the Rise

Increased likelihood of testing in men with comorbidity associated with hypogonadism.

Testosterone Therapy Does Not Increase Cardiovascular Risk

Testosterone Therapy Does Not Increase Cardiovascular Risk

Testosterone replacement therapy (TRT) does not increase cardiovascular disease (CVD) risk.

Rising PSA with Testosterone Gel Linked with Specific Factors

Rising PSA with Testosterone Gel Linked with Specific Factors

Greater PSA increases seen in older men and those with lower baseline testosterone.

Testosterone Replacement Therapy (TRT) Beneficial in Diabetes Mellitus Patients

Testosterone Replacement Therapy (TRT) Beneficial in Diabetes Mellitus Patients

Testosterone replacement therapy (TRT) may lower hemoglobin levels and improve lipid profile in diabetic men with androgen deficiency.

Low Testosterone Raises Atherosclerosis Risk in Diabetic Men

Low Testosterone Raises Atherosclerosis Risk in Diabetic Men

Low total testosterone was associated with increased odds of greater carotid intima-media thickness and odds of endothelial dysfunction.

Testosterone Replacement Therapy (TRT) May Promote Prostate Tumor Growth

Testosterone Replacement Therapy (TRT) May Promote Prostate Tumor Growth

Testosterone replacement therapy (TRT) may promote prostate cancer tumor growth.

Low Testosterone Raises Atherosclerosis Risk in Diabetics

Low Testosterone Raises Atherosclerosis Risk in Diabetics

Low testosterone may increase cardiovascular (CV) risk in middle-aged men with type 2 diabetes.

Testosterone Therapy Does Not Raise Heart Attack Risk

Testosterone Therapy Does Not Raise Heart Attack Risk

Testosterone therapy for men who produce little to no hormones does not increase heart attack risk.

FDA Panel: Limit Testosterone Drug Use

FDA Panel: Limit Testosterone Drug Use

Joint committee also calls for drug makers to run heart-risk tests on popular 'Low T' products.

Insufficient Data on Benefits, Risks of Testosterone Drugs

Insufficient Data on Benefits, Risks of Testosterone Drugs

Expert panel to decide whether prescribing information on testosterone drugs should be changed.

Common Chemicals Lower Testosterone

Common Chemicals Lower Testosterone

Chemicals found in many household products may reduce androgen levels in both sexes.

Obesity Diminishes Sexual Function in Young Men

Obesity Diminishes Sexual Function in Young Men

Obesity can lead to a deterioration of erectile function in young men.

Testosterone Supplements Not Linked to Heart Attacks

Testosterone Supplements Not Linked to Heart Attacks

Finding runs counter to some prior reports; much larger trials are needed, experts say.

Topical Testosterone Gel Approved

Topical Testosterone Gel Approved

In a study, 74% of men treated with Vogelxo achieved normal testosterone levels within 90 days.

Long-Term Testosterone Therapy Does Not Raise PCa Risk

Long-Term Testosterone Therapy Does Not Raise PCa Risk

Researchers report findings from a study of 942 hypogonadal men treated at 3 German centers.

FDA Clears First Nasal Testosterone Therapy

FDA Clears First Nasal Testosterone Therapy

The product is self-administered via a nasal applicator.

Erectile, Ejaculatory Dysfunction More Common in Cardiac Patients

Erectile, Ejaculatory Dysfunction More Common in Cardiac Patients

Study also shows a 6-fold higher rate of hypogonadism compared with the general population.

Testosterone Therapy Does Not Improve Glucose Metabolism

Testosterone Therapy Does Not Improve Glucose Metabolism

For men with T2DM and low testosterone, tx also doesn't improve visceral adiposity.

Low Testosterone May Signal Need for PCa Reclassification

Low Testosterone May Signal Need for PCa Reclassification

Drop in testosterone levels in patients on active surveillance may predict need for treatment.

New Tool May Aid Screening for Low Testosterone

New Tool May Aid Screening for Low Testosterone

Weight, frequent exercise, and adult-onset diabetes are among the risk factors for hypogonadism.

Hypogonadism May Raise Death Risk in Men with CKD

Hypogonadism May Raise Death Risk in Men with CKD

Patients in the second lowest quintile of testosterone level had a 53% increased death risk compared with those in the highest quintile.

Long-Term TRT Leads to Progressive Weight Loss, Other Benefits

Long-Term TRT Leads to Progressive Weight Loss, Other Benefits

Parenteral testosterone undecanoate over 5 years found to decrease waist circumference and improve components of metabolic syndrome.

High Estradiol Boosts Libido in Men on Testosterone Therapy

High Estradiol Boosts Libido in Men on Testosterone Therapy

Elevated serum estradiol is associated with increased libido in men receiving TST.

Early AM Best for Measuring Testosterone in Younger Men with ED

Early AM Best for Measuring Testosterone in Younger Men with ED

In men aged 44 years or less, total testosterone levels drop off significantly after 9 AM, study shows.

Testosterone Therapy Raises Myocardial Infarction Risk

Testosterone Therapy Raises Myocardial Infarction Risk

Risk is higher in younger men with pre-existing heart disease and in older men.

FDA to Review Testosterone Therapy Safety

FDA to Review Testosterone Therapy Safety

Agency pointed to recent studies citing possible heightened heart risk tied to the treatments.

Low Testosterone May Predict Worse Prostate Cancer Outcomes

Low Testosterone May Predict Worse Prostate Cancer Outcomes

Preoperative levels below 300 ng/dL are associated with an increased risk of positive surgical margins and seminal vesicle invasion.

Testosterone Therapy May Be Safe for Prostate Cancer Patients

Testosterone Therapy May Be Safe for Prostate Cancer Patients

In fact, a study showed that testosterone replacement is associated with a decreased risk of cancer-specific and overall mortality.

Testosterone May Weaken Vaccine Response

New findings could help explain why women generally respond immunologically to vaccines more strongly than men.

Testosterone May Ease Inflammatory Bowel Disease in Hypogonadal Men

Testosterone May Ease Inflammatory Bowel Disease in Hypogonadal Men

Long-term treatment led to a decrease in Crohn's Disease Activity Index and high-sensitivity C-reactive protein.

Mortality Risk in Older Men Linked to Testosterone

Mortality Risk in Older Men Linked to Testosterone

Australian researchers report that testosterone levels may predict mortality risk in older men.

TRT Doesn't Worsen Urinary Tract Symptoms

TRT Doesn't Worsen Urinary Tract Symptoms

About 30 percent of men experience an AUA symptoms index improvement of 3 or more points.

Optimal Testosterone Levels Predict Better Survival in Older Men

Midrange levels of total testosterone and dihydrotestosterone are associated with decreased all-cause mortality.

Hypogonadal Men with ED May Benefit from Testosterone Plus Vardenafil

The drug combination was associated with significantly improved erectile function and partner satisfaction in men who did not respond to testosterone alone.

Testosterone Therapy May Raise Cardiovascular Risk

In a study, it was associated with a 29% increased risk of death and/or heart attack or stroke.

Role of Testosterone in Heart Risk Unclear

Men with low testosterone levels may be at slightly increased risk of developing or dying from cardiovascular disease.

Hypogonadal Men with BPH Benefit from Dutasteride

Improvements observed in urinary symptoms and bone mineral density.

Anastrozole Improves Testosterone Therapy

The drug increases testosterone levels by lower serum estradiol levels.

Hypogonadism Prevalence High in Obese BPH/LUTS Sufferers

Men with a body mass index of 30 kg/m2 or higher had a 39.3% prevalence of low testosterone, study finds.

TRT Eases Urinary Symptoms in Men with Late-Onset Hypogonadism

Significant declines in International Prostate Symptom Score observed, regardless of whether or not men lost weight or used a phosphodiesterase-5 inhibitor.

Testosterone Therapy Eases MetS Components in Hypogonadal Men

Researchers observed significant improvements in lipid parameters, blood glucose, and blood pressure.

Testosterone Replacement Fails to Improve Cardiovascular Health

Testosterone Replacement Fails to Improve Cardiovascular Health

A new clinical review on cardiovascular disease and testosterone published between 1970 and 2013 has turned up mixed findings.

Low Testosterone More Likely in Prediabetics

Prediabetes increases the risk of testosterone deficiency nearly twofold.

Metabolic Syndrome Linked to Low Testosterone

Testosterone levels in the lowest versus the highest quintile are associated with a 15-fold increased risk of metabolic syndrome, study finds.

Low Testosterone Associated with Increased Dementia Risk

Low bioavailable testosterone significantly increased the risk in men aged 80 and older.

Effects of Testosterone on CVD Uncertain

Effects of Testosterone on CVD Uncertain

Review of the literature conducted to assess low testosterone link to cardiovascular disease/mortality.

Data Point to Nocturia-Hypogonadism Link

Desmopressin appears to reduce nocturia and other LUTS while also significantly increasing testosterone levels in late-onset hypogonadism.

Long-Term Testosterone Benefits Obese Hypogonadal Men

Study demonstrates that men experience steady weight loss and decrease in waist circumference.

Low Estrogen Explains Some Hypogonadal Symptoms in Men

New findings could improve the evaluation and management of men with hypogonadism.

Hypogonadism Linked to Anabolic Steroid Use

Prior use of AAS is common among young men seeking treatment for symptomatic hypogonadism.

Testosterone Loss May Set Stage for Parkinson's Disease

Findings from a mouse study implicate increased nitric oxide production.

Hypogonadism Ups Death Risk in Men on Hemodialysis

In a study, 55% of male hemodialysis patients had low testosterone.

Testosterone Therapy Unlikely To Worsen Urinary Symptoms

Lower urinary tract symptoms actually improved in many men, with minimal change in PSA level.

Testosterone Helps Improve Pain Perception, Quality of Life

Testosterone Helps Improve Pain Perception, Quality of Life

A new study looking at men with low testosterone levels has found that testosterone therapy helps improve pain perception and quality of life.

Profound Hypogonadism Linked to Anabolic Steroid Use

Hypogonadal men younger than 50 years were more than 10 times as likely as men older than 50 to have prior exposure to anabolic androgenic steroids.

PSA Levels May Predict Hypogonadism

PSA levels below 0.65 ng/mL provide the best sensitivity and specificity (65.2% and 55.5%, respectively) for predicting severe hypogonadism.

Testosterone Therapy Does Not Raise Prostate Cancer Recurrence Risk

After radical prostatectomy, men who received testosterone therapy for hypogonadism had a lower rate of biochemical recurrence than nonhypogonadal men.

Testosterone Therapy Does Not Hike Risk of Aggressive Prostate Cancer

Study also reveals very low use of testosterone replacement therapy among men in the United States

Study: Testosterone Therapy Takes off Pounds

BMI and waist circumference declined in hypogonadal men treated with parenteral testosterone undecanoate.

Prostate Cancer Risk Not Higher with TRT Use

Researchers studied 850 testosterone-deficient men who received 1,000 mg parenteral testosterone undecanoate six weeks after baseline and then every 12 weeks for up to five years.

Elderly Men Benefit from TRT, Study Finds

Hypogonadal men aged 65 years and older experience significant benefit from TRT over 12 months.

Low Testosterone Linked to Long-Acting Opioids

Low Testosterone Linked to Long-Acting Opioids

California researchers have found that low testosterone levels occur five times more often among men taking long-acting opioids.

Long-Acting Daily Opioids Increase Risk of Hypogonadism

Long-Acting Daily Opioids Increase Risk of Hypogonadism

In men taking daily opioids, duration of action, but not dose, affects risk of hypogonadism

Minimal Priapism Risk with AndroGel 1% Use

Researchers reviewed clinical trial and postmarketing data.

Sildenafil's Effect Not Enhanced with Testosterone

Adding testosterone therapy to sildenafil is not more effective in treating erectile dysfunction (ED) than sildenafil alone,

Testosterone Doesn't Add to Erectile Response With Sildenafil

Testosterone Doesn't Add to Erectile Response With Sildenafil

Sildenafil plus testosterone not superior for men with erectile dysfunction, low testosterone.

Testosterone Deficiency To Have Big Public Health Impact

Researchers predict about 1.3 million new cases of cardiovascular disease related to low testosterone over a 20-year period.

How concerned are you that placing hypogonadal men on testosterone replacement therapy might promote development of prostate cancer (PCa) or progression of undiagnosed PCa?

Many physicians remain wary about starting testosterone replacement therapy (TRT) in hypogonadal men in large part out of concern that it could cause progression of undiagnosed prostate cancer (PCa) or promote PCa development.

Testosterone Therapy Safe for the Prostate

Long-term treatment found not to increase the incidence of prostate cancer.

Prostate Cancer No More Likely to Develop After Testosterone Therapy

Finding was based on a study of 1,365 men with symptomatic androgen deficiency.

Lifestyle Changes May Boost Testosterone

Measures that led to weight loss found to raise levels significantly in overweight, prediabetic men.

Study Shows Health Benefits of Testosterone Replacement

Study Shows Health Benefits of Testosterone Replacement

Treatment is associated with weight loss and improvements in components of metabolic syndrome.

Testosterone Declines Not Inevitable

Testosterone Declines Not Inevitable

Study implicates factors other than aging, including weight gain, smoking cessation, depression and cardiovascular disease.

Testosterone Therapy Does Not Up Prostate Cancer Incidence

Testosterone Therapy Does Not Up Prostate Cancer Incidence

One case of cancer diagnosed per 212 years of testosterone replacement therapy

New Formulations of Androderm Approved

The FDA has approved two lower-dose formulations for Androderm, a once-daily transdermal patch for men with low testosterone.

Testosterone Therapy May Not Improve Erectile Dysfunction

ORLANDO, Fla.—Testosterone supplementation in elderly men with borderline low testosterone levels may not improve erectile dysfunction (ED) compared with placebo, new findings suggest.

Male Hypogonadism Linked to Ratio of Finger Lengths

The ratio of the second and fourth finger lengths (2D/4D ratio) may predict which men have testosterone deficiency, researchers reported.

Underarm Testosterone Therapy Cleared

WASHINGTON, D.C.—The FDA has approved the first and only testosterone therapy applied to the underarm.

FDA Approves New AndroGel Formulation

The FDA has approved Abbott's AndroGel 1.62%, a testosterone gel that restores levels of the hormone in hypogonadal men with half the volume of gel at the starting dose than delivered in AndroGel 1%.

Hypogonadism and Metabolic Syndrome

Hypogonadism and Metabolic Syndrome

Low testosterone increases fat mass and visceral obesity, which is associated with insulin resistance.

Relationships of Testosterone and Prostate Cancer: A 2011 Perspective

Relationships of Testosterone and Prostate Cancer: A 2011 Perspective

A history of prostate cancer has generally been a contraindication for testosterone therapy, but the clinical model may be changing.

Testosterone Safe for Prostates

Testosterone Safe for Prostates

VIENNA—Testosterone replacement therapy benefits hypogonadal men without adversely affecting prostate safety, according to the largest international trial of hypogonadal men receiving the treatment.

Saliva Test Identifies Hypogonadism in ESRD Patients

Salivary testosterone (Sal-T) can be used to diagnose androgen deficiency reliably in men with end-stage renal disease (ESRD), according to a Brazilian study.

DHT Does Not Affect Prostate Growth

Dihydrotestosterone (DHT) treatment over two years does not halt prostate growth, according to study findings published in the Annals of Internal Medicine (2010;153:621-632).

Low Testosterone May Raise Death Risk in Men with CHD

A study of 930 men with coronary heart disease (CHD) showed that those who had testosterone deficiency were at increased risk of death.

FDA Clears Testosterone Gel

The FDA has approved a testosterone replacement therapy gel, a colorless and odorless preparation applied with one finger to the front and inner thighs.

Standardization: The Future of Testosterone Testing

Endocrinologist William Rosner, MD, Professor of Medicine at Columbia University in New York, explains to Renal & Urology News what impending testosterone-testing standardization—and the current lack of it—means to urology practice and research.

Hypogonadism Linked to Statin Use

Statin therapy may induce primary hypogonadism and should be considered a possible confounding factor when evaluating testosterone levels in patients with erectile dysfunction (ED), according to Italian researchers.

Testosterone Treatment May Have Non-Sexual Benefits

In elderly hypogonadal men, it can improve components of the metabolic syndrome, a study found

Low Testosterone Increases Mortality Risk

SAN FRANCISCO—Low serum testosterone levels may be associated with an increased risk of death from cardiovascular causes and cancer, independent of age and other risk factors, according to a recent population-based study.

Low Testosterone May Increase Mortality

TORONTO—Androgen deficiency in men aged 50 years and older may be associated with an increased risk of death, independent of adiposity and lifestyle choices, a study suggests. This association may be explained, in part, by the metabolic syndrome and elevated markers of inflammation.

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