Hyperuricemia

High Uric Acid Ups Renal Failure Risk in Some CKD Patients

High Uric Acid Ups Renal Failure Risk in Some CKD Patients

By

Among CKD patients with an eGFR of 45 mL/min/1.73 m2 or above, each 1 SD increase in baseline uric acid levels is independently associated with a 40% increased risk of kidney failure.

FDA Issues Safety Alert for Gout Medication

FDA Issues Safety Alert for Gout Medication

By

Febuxostat may increase the risk for heart-related death.

Uric Acid-Lowering Therapy Helps Kidney, Heart

Uric Acid-Lowering Therapy Helps Kidney, Heart

Uric acid-lowering therapy might improve kidney outcomes, including kidney failure events, proteinuria, and the rate of change in eGFR, and seem to reduce the risk of cardiovascular events in adults with CKD.

Rapid Kidney Function Decline in Blacks Linked to Elevated Uric Acid

Rapid Kidney Function Decline in Blacks Linked to Elevated Uric Acid

By

Each 1 standard deviation in baseline uric acid levels was associated with a significant 80% increased odds of rapid kidney function decline.

Metoprolol Increases Uric Acid, Risk of Gout

Metoprolol Increases Uric Acid, Risk of Gout

By

In a study of African Americans with hypertension-related CKD, metoprolol, but neither ramipril nor amlodipine, increased serum uric acid levels.

Erectile Dysfunction Risk Higher in Gout Patients

Erectile Dysfunction Risk Higher in Gout Patients

By

The risk for developing erectile dysfunction is 15% higher among men with than without gout.

Gout Patient Hospitalizations Soar

Gout Patient Hospitalizations Soar

By

All-cause hospitalizations in the US increased 410% from 1993 to 2014 among gout sufferers compared with 4.8% in the general population.

Gout Risk Is Lower Among Healthier Eaters

Gout Risk Is Lower Among Healthier Eaters

By

A DASH-style diet is associated with a reduced risk of gout, whereas a Western diet is associated with a higher risk.

Most US Gout Sufferers Not Taking Urate-Lowering Drugs

Most US Gout Sufferers Not Taking Urate-Lowering Drugs

By

Gout is uncontrolled in the majority of individuals with the condition, data show.

Women With Gout at Greater Risk for Hip Fracture

Women With Gout at Greater Risk for Hip Fracture

The multivariable-adjusted relative risk of hip fracture was 1.38 in women with history of gout.

Black Gout Sufferers Have Worse HRQoL

Black Gout Sufferers Have Worse HRQoL

By

Blacks had significantly higher median baseline serum urate levels compared to whites.

Allopurinol May Benefit The Kidneys

Allopurinol May Benefit The Kidneys

By

The allopurinol group had a significant 0.10 mg/dL lower final creatinine level than controls.

DASH Diet Lowers Uric Acid in Pre-, Early Hypertension

DASH Diet Lowers Uric Acid in Pre-, Early Hypertension

The DASH diet lowered serum uric acid, and this effect was greater among participants with hyperuricemia.

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

By

Odds of acute kidney injury increases by 29% with each 1 mg/dL increment in uric acid level at ICU admission.

Uric Acid-Lowering Benefit of Lesinurad Confirmed

Uric Acid-Lowering Benefit of Lesinurad Confirmed

By

Benefit of adding the uricosuric drug to a xanthine oxidase inhibitor persists for up to 2 years, extension study shows.

ACP Releases New Gout Guidelines

ACP Releases New Gout Guidelines

By

The guidelines recommend treatment strategies and state that evidence is insufficient to support therapy to lower uric acid to target levels.

New Oral Treatment for Hyperuricemia Tied to Gout

New Oral Treatment for Hyperuricemia Tied to Gout

Zurampic, a URAT1 inhibitor, can be combinated with a xanthine oxidase inhibitor to treat hyperuricemia tied to gout.

Uric Acid Threshold That Predicts Kidney Stone Formation Identified

Uric Acid Threshold That Predicts Kidney Stone Formation Identified

By

Serum uric acid levels of 10 mg/dL or higher are associated with an increased risk for nephrolithiasis.

Lesinurad Improves Uric Acid Lowering in Gout Sufferers

Lesinurad Improves Uric Acid Lowering in Gout Sufferers

By

Using the drug together with allopurinol helps more patients achieve target uric acid levels of less than 6 mg/dL.

DASH Diet May Protect Against Kidney Disease

DASH Diet May Protect Against Kidney Disease

By

In a study, CKD was 16% less likely to develop in low adherers to a DASH dietary pattern.

Gout Found to Increase Type 2 Diabetes Risk

Gout Found to Increase Type 2 Diabetes Risk

By

The effect of gout on type 2 diabetes risk was more profound in women than men.

Venous Thromboembolism Linked to High Uric Acid

Venous Thromboembolism Linked to High Uric Acid

By

Highest vs lowest uric acid levels associated with a 2-fold increased risk of VTE.

High Uric Acid Increases Risk of Non-Fatal Stroke in CKD Patients

High Uric Acid Increases Risk of Non-Fatal Stroke in CKD Patients

By

Odds of non-fatal stroke are 49% higher in patients in the fourth quartile of uric acid level versus those in the second quartile.

Most Gout Inadequately Controlled

Most Gout Inadequately Controlled

Patients with inadequately controlled gout experience lower quality of life and report worse functioning.

Uric Acid Levels Low in Adolescents With Type 1 Diabetes

Uric Acid Levels Low in Adolescents With Type 1 Diabetes

Unlike in adults, there is no association between uric acid, cardiorenal parameters.

Febuxostat May Slow Renal Decline in Hyperuricemic CKD Patients

Febuxostat May Slow Renal Decline in Hyperuricemic CKD Patients

By

Patients treated with the uric acid-lowering drug were less likely to experience a greater than 10% decline in eGFR than placebo recipients.

High Uric Acid Raises ESRD Risk

High Uric Acid Raises ESRD Risk

By

The highest vs. lowest quartile of serum uric acid is associated with a 3.4-fold increased risk of end-stage renal disease.

Researchers: View Gout as a Warning Sign

Researchers: View Gout as a Warning Sign

By

Gout is associated with an elevated risk of comorbid conditions, especially hypertension and alcohol abuse.

High Uric Acid Levels Up Death Risk in the Elderly

High Uric Acid Levels Up Death Risk in the Elderly

By

Highest vs. lowest quartile associated with a 17% increased risk.

High Uric Acid Levels Tied to Early Death in Seniors

High Uric Acid Levels Tied to Early Death in Seniors

Association strongest with cardiovascular mortality in the elderly.

Sign Up for Free e-newsletters