Women With Gout at Greater Risk for Hip Fracture

The multivariable-adjusted relative risk of hip fracture was 1.38 in women with history of gout.
The multivariable-adjusted relative risk of hip fracture was 1.38 in women with history of gout.

(HealthDay News) — For women, a history of gout is associated with increased risk of hip fracture, according to a study published online in Arthritis & Rheumatology.

Julie M Paik, MD, MPH, from Brigham and Women's Hospital in Boston, and colleagues conducted a prospective observational study of gout and the risk of incident wrist and hip fracture among 103,799 women participating in the Nurses' Health Study. Biennial questionnaires were used to assess gout history and incident cases of wrist and hip fracture.

The researchers identified 3769 incident wrist fractures in 1990 to 2004 and 2147 incident hip fractures in 1990 to 2012; 107 and 117 of these, respectively, occurred in participants with gout. The multivariable-adjusted relative risk of wrist fracture was 1.12 (95% confidence interval, 0.92 to 1.36) and of hip fracture was 1.38 (95% confidence interval, 1.14 to 1.68) for women with a history of gout vs those without gout.

"In women, a history of gout is associated with a modestly increased risk of hip fracture, but not significantly associated with a risk of wrist fracture," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Reference

  1. Paik JM, Kim SC, Feskanich D, et al. Gout and Risk of Fracture in Women: A Prospective Cohort Study. Arthritis Rheumatol. February 2017. doi: 10.1002/art.39852
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