White-Coat, Masked Hypertension Tied to CVD, Kidney Complications

Both associated with increased aortic stiffness, renal injury, incident cardiovascular events
Both associated with increased aortic stiffness, renal injury, incident cardiovascular events

(HealthDay News) -- Both white-coat hypertension (WCH) and masked hypertension (MH) are associated with target organ complications and cardiovascular event risk, according to a study published in the Journal of the American College of Cardiology.

Danielle Tientcheu, MD, from the University of Texas Southwestern Medical Center in Dallas, and colleagues determined hypertensive target organ damage and adverse cardiovascular outcomes associated with WCH (high clinic BP, normal home BP), MH (high home BP, normal clinic BP), and sustained hypertension in a large multiethnic population cohort of 3,027 subjects. Over a median follow-up period of 9 years, correlations for WCH and MH with incident cardiovascular outcomes (coronary heart disease, stroke, atrial fibrillation, heart failure, and cardiovascular death) were assessed.

The researchers found that the sample-weighted prevalence rates were 3.3% for WCH and 17.8% for MH. Independent correlations were seen for both WCH and MH with increased aortic pulsed wave velocity, cystatin C, and urinary albumin-to-creatinine ratio. Compared with the normotensive group, both WCH and MH correlated with increased cardiovascular events (adjusted hazard ratios, 2.09 and 2.03, respectively) after adjustment for traditional cardiovascular risk factors.

"Because MH is common and associated with an adverse cardiovascular profile, home BP monitoring should be routinely performed among U.S. adults," the authors write.

Sources

  1. Tientcheu D, Ayers C, Das SR, et al. Target Organ Complications and Cardiovascular Events Associated With Masked Hypertension and White-Coat Hypertension. J Am Coll Cardiol. 2015;66(20):2159-2169. doi:10.1016/j.jacc.2015.09.007.
  2. Verdecchia P, Angeli F, and Reboldi G. Masked and White-Coat Hypertension. J Am Coll Cardiol. 2015;66(20):2170-2172. doi:10.1016/j.jacc.2015.09.008.
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