UAER Predicts Blood Pressure Changes
Urinary albumin excretion rate also is associated with development of hypertension.
Urinary albumin excretion rate (UAER) in elderly men is significantly associated with blood pressure (BP) progression and hypertension incidence, according to a Swedish study published online ahead of print in Nephrology Dialysis Transplantation.
In an observational study conducted by visiting researcher Hong Xu, MD, and colleagues at the Karolinska Institutet in Stockholm, 1,051 men over the age of 71 were assessed for UAER, 24-hour ambulatory BP monitoring (ABPM), and cystatin-C estimated glomerular filtration rate (eGFR). Data was extracted from the Uppsala Longitudinal Study of Adult Men.
At both baseline and longitudinal analysis, UAER was found to be associated with ABPM. In patients with eGFR of less than 60 mL/min/1.73 m2, UAER was an independent predictor of BP changes. In addition, it was a predictor of incident hypertension only in patients with reduced renal function.
After 6 years, 574 men were re-evaulated for ABPM and incidence of hypertension. Researchers identified 71 news cases of hypertension.