Study: 24-Hour ABP Beats eGFR as CVD-Risk Predictor

Twenty-four hour ambulatory blood pressure (ABP) measurements are a better predictor of cardiovascular disease risk in the general population than estimated glomerular filtration rate (eGFR), data show.

Researchers recorded health outcomes among 5,322 randomly selected participants from 11 general populations. Subjects had a median age of about 52 years and 43% were female. All subjects had baseline measurements of 24-hour ABP and eGFR. The median follow-up was 9.3 years.

In fully adjusted models, 24-hour ABP was a significant predictor of both total and cardiovascular deaths, whereas eGFR only predicted cardiovascular mortality, a team led by Jan A. Staessen, MD, PhD, of the University of Leuven in Leuven, Belgium, reported online ahead of print in Hypertension. Additionally, 24-hour ABP was a significant predictor of the combination of fatal and nonfatal events as a result of all cardiovascular causes, cardiac disease, or stroke, whereas eGFR was a significant predictor only of a composite cardiovascular endpoint and stroke.

With respect to cardiovascular mortality, the composite cardiovascular endpoint, and stroke, 24-hour ABP added 0.35%, 1.17%, and 1.0%, respectively, to the risk already explained by cohort, gender, age, body mass index, previous cardiovascular disease, drinking and smoking, diabetes mellitus, and antihypertensive drug treatment, according to Dr. Staessen's group. Adding eGFR explained an additional 0.13%, 0.09%, and 0.14%, respectively, they noted.

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