Angiotensin Receptor Blockers, ACE Inhibitors Similarly Effective

This article originally appeared here.
Research challenges previous findings that suggest ACE inhibitors have greater benefits.
Research challenges previous findings that suggest ACE inhibitors have greater benefits.

(HealthDay News) -- Angiotensin receptor blockers (ARBs) are just as effective and safe as angiotensin-converting enzyme inhibitors (ACEIs), according to research published in Mayo Clinic Proceedings.

Sripal Bangalore, MD, of the Leon H. Charney Division of Cardiology at the New York University School of Medicine in New York City, and colleagues reviewed 106 randomized trials involving 254,301 patients to examine the effects of ARBs and ACEIs.

Although ACEIs were developed 10 years earlier, both types of drugs showed similar effects in the analysis, challenging previous findings that suggest ACEIs have greater benefits. According to the new analysis, the only difference between the medications is that ARBs are more easily tolerated.

"There has been debate for many years over the safety and efficacy of ACE inhibitors compared to ARBs, with many of them using an 'ACE inhibitor-first' approach, with ARBs regarded as less effective," Bangalore said in a NYU Langone Medical Center news release. "We believe that our study ends the debate and gives physicians the option to prescribe either drug for their patients."

Several authors disclosed financial ties to the pharmaceutical industry.

Source

  1. Bangalore S, Fakheri R, Toklu B, et al. Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients Without Heart Failure? Insights From 254,301 Patients From Randomized Trials. Mayo Clin Proc. doi: 10.1016/j.mayocp.2015.10.019.
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