6-Minute Walk Test Predicts Outcomes in Pulmonary Hypertension Patients

Findings in patients with pulmonary hypertension linked to heart failure and preserved ejection fraction
Findings in patients with pulmonary hypertension linked to heart failure and preserved ejection fraction

(HealthDay News) -- For patients with pulmonary hypertension associated with heart failure and preserved ejection fraction (PH-HFpEF), the 6-minute walk distance (6-MWD) test can independently predict outcome, according to a study published in the June issue of JACC: Heart Failure.

Caroline Zotter-Tufaro, from the Medical University of Vienna, and colleagues examined the prognostic significance and clinical determinants of the 6-MWD. Data were included for 142 patients with PH-HFpEF, as confirmed by right heart catheter.

The researchers found that 30.3% of patients reached the combined end point of hospitalization for heart failure and/or death for cardiac reasons after a mean follow-up of 14.0 months. The 6-MWD independently predicted outcome and was affected by clinical, echocardiographic, hemodynamic, laboratory, and pulmonary parameters. The 6-MWD and the extent of extracellular matrix in the left ventricular myocardium were significantly inversely correlated.

"Impaired exercise capacity in PH-HFpEF patients is explained by cardiac and noncardiac factors," the authors write. "The 6-MWD predicts outcome and may be a useful end point in clinical trials."

Source

  1. Zotter-Tufaro, C, et al. JCHF. 2015;3(6):459-466; doi:10.1016/j.jchf.2015.01.010.
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