Hyperphosphatemia

Fixed-Dose Phosphate Binder Schedules May Be Less than Ideal

Fixed-Dose Phosphate Binder Schedules May Be Less than Ideal

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Study of peritoneal dialysis patients showed that they do not adjust binders to match the phosphate content of meals and snacks.

Personalized Diet Improves CKD-Related Risks

Personalized Diet Improves CKD-Related Risks

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A low protein diet of vegetable proteins along with reduced intake of specific micronutrients should be recommended to stage 3-4 CKD patients, researchers say.

Individual Variability Overlooked in Uncontrolled Hyperphosphatemia

Individual Variability Overlooked in Uncontrolled Hyperphosphatemia

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Expert suggests factors beyond poor adherence to a low phosphorus diet and binder therapy may contribute to hyperphosphatemia.

Phosphate Binders Show Similar Efficacy in African Americans

Phosphate Binders Show Similar Efficacy in African Americans

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Study compared sucroferric oxyhydroxide and sevelamer carbonate.

CKD Severity Linked to Low BMD, Hip Fracture, and Mortality

CKD Severity Linked to Low BMD, Hip Fracture, and Mortality

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The risk of dying following a hip fracture was 6.5 times higher for patients with severe CKD than for those with normal kidney function or mild CKD.

CKD-MBD May Play Role in Restless Legs Syndrome in Dialysis Patients

CKD-MBD May Play Role in Restless Legs Syndrome in Dialysis Patients

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Phosphate and vitamin D deficiency were linked with RLS severity.

High Phosphorus, Cerebral Hemorrhage Linked in HD Patients

High Phosphorus, Cerebral Hemorrhage Linked in HD Patients

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Researchers observe a 2.2-fold increased risk in patients with serum phosphate levels of 6.0 mg/dL or higher.

High Phosphate Increases Mortality Risk in CKD Patients

High Phosphate Increases Mortality Risk in CKD Patients

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Meta-analysis finds that each 1 mg/dL increase in serum phosphate increases the risk of death by 23%.

Sucroferric Oxyhydroxide Reduces Phosphorus, Binder Pill Burden

Sucroferric Oxyhydroxide Reduces Phosphorus, Binder Pill Burden

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Researchers observe a significant mean decrease in binder pills from 8.4 to 3.8 pills per day.

HD Patients with Lowest FGF-23 Level Have Lowest Survival Rate

HD Patients with Lowest FGF-23 Level Have Lowest Survival Rate

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Cumulative 2-year survival rate was 65.4%, 78.9%, 85.1%, and 80.6% among patients in the 1st, 2nd, 3rd, and 4th quartiles.

Stopping Cinacalcet for Non-Medical Reasons Ups Death Risk

Stopping Cinacalcet for Non-Medical Reasons Ups Death Risk

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About 3 additional deaths per 100 persons occur when the drug is discontinued due to non-medical versus medical reasons during the first year.

Ferric Citrate Reduces Hyperphosphate, EPO Requirement

Ferric Citrate Reduces Hyperphosphate, EPO Requirement

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Significant decreases in serum phosphate and erythropoietin dose in hemodialysis patients observed after 6 months of treatment.

Restricting Dietary Protein and Phosphorus May Improve CKD-MBD

Restricting Dietary Protein and Phosphorus May Improve CKD-MBD

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Very low protein intake was not superior to traditional low protein diets, however.

Nocturnal Dialysis Linked with Reduced Left Ventricular Mass

Nocturnal Dialysis Linked with Reduced Left Ventricular Mass

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Recipients of in-hospital nighttime dialysis experienced a 14.2 gram reduction in left ventricle thickening.

Phosphorus-Based Food Additives May Impact Bone Metabolism

Phosphorus-Based Food Additives May Impact Bone Metabolism

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Even healthy adults show evidence of abnormal bone metabolism.

Higher Phosphorus Ups Anemia Risk

Higher Phosphorus Ups Anemia Risk

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Researchers find link in the non-dialysis population.

Elevated Phosphorus Predicts Mortality in Men

Elevated Phosphorus Predicts Mortality in Men

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Large South Korean study demonstrates the association in individuals with normal kidney function.

Abnormal Mineral, Bone Markers in Dialysis Patients Hike Mortality

Abnormal Mineral, Bone Markers in Dialysis Patients Hike Mortality

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Large European study identifies ranges of phosphorus, calcium, and parathyroid hormone levels with the lowest death risk.

Serum Phosphorus Levels Not Affected by Race, Income

Serum Phosphorus Levels Not Affected by Race, Income

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African-American patients, however, had significantly higher intact parathyroid hormone levels, possibly due to lower 25-hydroxyvitamin D levels.

High Phosphorus Levels Predict CKD Progression, Early Death

High Phosphorus Levels Predict CKD Progression, Early Death

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Every 1 mg/dL increase in serum phosphorus level was linked with 36% greater odds of kidney failure among non-dialysis CKD patients.

Hyperphosphatemia Increases Mortality in Critically Ill Patients

Hyperphosphatemia Increases Mortality in Critically Ill Patients

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High phosphate levels are associated with 3.3-fold increased odds of 28-day in-hospital mortality.

Phosphate Binder Adherence Challenging for Dialysis Patients

Phosphate Binder Adherence Challenging for Dialysis Patients

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In a study, 45% of hemodialysis patients internationally reported skipping phosphate binder pills at least once in the prior month.

Coaching and Financial Incentives May Reduce Phosphorus

Coaching and Financial Incentives May Reduce Phosphorus

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Patients with hyperphosphatemia lowered their phosphorus levels with a dietitian's guidance or cash incentive.

Study Probes Boiling Methods for Cutting Phosphorus in Meat

Study Probes Boiling Methods for Cutting Phosphorus in Meat

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Boiling sliced meat in a pressure cooker filled with soft water may be a promising way for dialysis patients to reduce phosphorus intake.

Food Additives Found to Raise Serum Phosphorus

Food Additives Found to Raise Serum Phosphorus

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Study implicates dairy products, cereals, and grains containing inorganic phosphate additives.

Medications Contribute to Phosphate Intake

Medications Contribute to Phosphate Intake

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Among the phosphate-containing medicinal products prescribed to chronic kidney disease patients, 76% may contain absorbable phosphate.

Study: 30% Decline in eGFR Over 2 Years Strongly Predicts ESRD

Study: 30% Decline in eGFR Over 2 Years Strongly Predicts ESRD

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Baseline eGFR, higher phosphorus, proteinuria, and male gender, also are associated with an elevated risk of end-stage renal disease in patients with chronic kidney disease.

Risk Factors for CKD Progression ID'd

Risk Factors for CKD Progression ID'd

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Proteinuria, hyperphosphatemia, anemia linked more rapid annual decline in eGFR.

Dietary Interventions Improve Hyperphosphatemia Treatment

Dietary Interventions Improve Hyperphosphatemia Treatment

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Cutting back on dietary phosphorus in addition to taking phosphate binders achieved greater decreases in serum phosphate in PD patients.

Many Beverages Contain Hidden Phosphorus

Many Beverages Contain Hidden Phosphorus

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A study found that 78% of popular drinks, from flavored waters to lemonades to iced teas, contain far more phosphorus than listed in nutritional databases.

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