Hyperphosphatemia

Study Reveals Advantages of Non-Calcareous Phosphate Binders

Study Reveals Advantages of Non-Calcareous Phosphate Binders

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Use of these agents is associated with a much lower incidence of hypercalcemia compared with the use of calcium carbonate or calcium acetate.

Ferric Citrate Controls Phosphorus, Cuts ESA Use

Ferric Citrate Controls Phosphorus, Cuts ESA Use

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Over 52 weeks, the drug maintained hemoglobin levels while decreasing IV iron use in dialysis patients with anemia.

Insulin Resistance Linked to High Phosphorus in Maintenance Hemodialysis (MHD) Patients

Insulin Resistance Linked to High Phosphorus in Maintenance Hemodialysis (MHD) Patients

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In adjusted analyses, serum phosphorus levels independently predicted glucose disposal rate.

Higher Phosphorus, Cardiovascular Disease (CVD) Not Linked in Kidney Disease (CKD) Patients

Higher Phosphorus, Cardiovascular Disease (CVD) Not Linked in Kidney Disease (CKD) Patients

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Each 0.5 mg/dL increment in serum phosphorus associated with 58% increased odds of coronary heart failure (CHF).

Ferric Citrate Phosphate Binder Cuts Hospitalization Rates

Ferric Citrate Phosphate Binder Cuts Hospitalization Rates

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Rates for infection-, gastrointestinal-, and cardiac-related adverse events are lower than with sevelamer carbonate or calcium acetate.

Plant-Based Phosphorus Best for Kidney Disease (CKD) Patients

Plant-Based Phosphorus Best for Kidney Disease (CKD) Patients

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Plant-based diet had the lowest urinary phosphorus excretion, whereas an inorganic-based diet had the highest.

Extended Hemodialysis May Improve Phosphate Control

Extended Hemodialysis May Improve Phosphate Control

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Researchers observe significant decline in serum phosphate levels with 6 hours vs. 4 hours of treatment.

Higher Phosphorus Levels Predict Increased Death Risk in Men

Higher Phosphorus Levels Predict Increased Death Risk in Men

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No association between phosphorus levels and all-cause mortality in women.

Elevated Phosphorus Levels Raise Risk of Kidney Failure

Elevated Phosphorus Levels Raise Risk of Kidney Failure

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Every 1 mg/dL increase in serum phosphorus was independently associated with a 36% increased relative risk of kidney failure.

Hyperphosphatemia Raises Coronary Artery Calcification (CAC) Risk in Peritoneal Dialysis

Hyperphosphatemia Raises Coronary Artery Calcification (CAC) Risk in Peritoneal Dialysis

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Study of coronary artery calcification (CAC) risk also shows serum phosphorus levels associated with nutritional intake and dialysis adequacy.

Ferric Citrate Approved for Phosphorus Control in Chronic Kidney Disease (CKD) Patients

Ferric Citrate Approved for Phosphorus Control in Chronic Kidney Disease (CKD) Patients

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In addition to reducing serum phosphorus levels to within the recommended range, ferric citrate increases iron stores.

Novel Binder Lowers Phosphate with Fewer Pills

Novel Binder Lowers Phosphate with Fewer Pills

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In a study, PA21 was as efficacious as sevelamer carbonate, but patients taking PA21 had a lower pill burden and better adherence.

Elevated Phosphorus May Increase Death Risk

Elevated Phosphorus May Increase Death Risk

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Researchers observed the association among individuals with serum phosphorus levels measured after fasting for 12 or more hours.

Hospitalization Costs Lower with Ferric Citrate

Hospitalization Costs Lower with Ferric Citrate

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Use is associated with fewer hospitalizations versus sevelamer carbonate and calcium acetate.

Phosphorus Control Using PTH Tested

Phosphorus Control Using PTH Tested

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In mice with and without CKD, phosphorus levels decreased by an average of 35% by 6 hours after injection with long-acting PTH.

Lower Phosphorus, Higher Protein Intake Improve Survival

Lower Phosphorus, Higher Protein Intake Improve Survival

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Protein levels found to modify the effect of serum phosphorus with mortality in hemodialysis patients.

No Clinically Relevant Changes in Vitamin D with PA21

No Clinically Relevant Changes in Vitamin D with PA21

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Researchers compared the novel iron-based phosphate binder with sevelamer.

Team-Focused Approach Improves Phosphorus Control

Team-Focused Approach Improves Phosphorus Control

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In a study, nurses and technicians educated groups of hemodialysis patients about phosphate binders.

Multi-Prong Approach Has Little Effect on Phosphorus Control

Multi-Prong Approach Has Little Effect on Phosphorus Control

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Researchers tested an intervention that included an educational fair, phosphorus group social, and staff education on phosphate binders.

Limiting Phosphorus Additives Aids Phosphatemia Control

Limiting Phosphorus Additives Aids Phosphatemia Control

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Researchers observed reduced phosphorus levels in HD patients whose diet restricted intake of phosphorus additives.

Phosphorus Changes Affect Dialysis Patient Mortality Risk

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Declines in serum phosphorus over time may improve survival.

Higher PTH and Dietary Protein Intake Hikes Hyperphosphatemia Risk

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Worsening or resistant hyperphosphatemia may be an under-appreciated consequence of secondary hyperparathyroidism.

Phosphate Binders Offer No Short-Term Mortality Benefit

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Calcium-based and non-calcium-based binder use were associated with similar death risks.

Limiting Phosphorus Additives in Foods Lowers Serum Phosphorus

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Levels declined significantly from 7.2 to 5.0 mg/dL, data show.

Vascular Calcification Linked to Lower Phosphate Clearance

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Vascular calcification contributes to increased cardiovascular risk in dialysis patients.

Oxidative Stress May Be Why High Phosphorus Ups Mortality

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New findings are consistent with those from previous animal studies.

Novel Iron-Based Binder Has Long-Term Efficacy

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PA21 comparable in safety and efficacy to sevelamer carbonate out to 52 weeks, study finds.

Fasting Phosphorus Levels Are a Stronger Mortality Predictor

Fasting Phosphorus Levels Are a Stronger Mortality Predictor

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Serum levels vary throughout the day, and higher phosphorus intake exaggerates the early afternoon rise in serum phosphorus.

Race May Affect Phosphorus-Mortality Link in CKD Patients

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New findings raise questions "on the generalizability of previous research studies to the clinic setting," researchers conclude.

High Phosphorus Ups Dialysis Patient Death Risk Regardless of Age

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Low phosphorus increases all-cause and cardiovascular mortality only among the elderly.

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