Hyperphosphatemia

Researchers: Iron-based Binders Best for Hyperphosphatemia

Researchers: Iron-based Binders Best for Hyperphosphatemia

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Of 7 phosphate binders, iron-based agents were optimal when efficacy and safety are considered.

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

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Almost 40% of pre-dialysis patients with stage 4-5 CKD patients and type 2 diabetes had lab results suggesting low turnover bone disease.

Short-term Interleukin Inhibition Ineffective in CKD-MBD

Short-term Interleukin Inhibition Ineffective in CKD-MBD

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Serum phosphorus and intact parathyroid hormone levels were not reduced with 12 weeks of rilonacept therapy.

Hyperphosphatemia May Predict Diastolic Dysfunction in CKD

Hyperphosphatemia May Predict Diastolic Dysfunction in CKD

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CKD patients with and without diastolic dysfunction had average serum phosphate levels of 7.3 and 5.5 mg/dL, respectively.

Iron-based Binder Improves Phosphorus Levels in Dialysis Patients

Iron-based Binder Improves Phosphorus Levels in Dialysis Patients

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The proportion of patients with serum phosphorus levels within target range rose from 22% to 65% within 6 months of starting ferric citrate treatment.

Add-on Sevelamer Therapy May Improve Hemodialysis Patient Survival

Add-on Sevelamer Therapy May Improve Hemodialysis Patient Survival

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Use of sevelamer was associated with a 14% decreased risk of death compared with non-use.

Guidelines for CKD Mineral and Bone Disorder Updated

Guidelines for CKD Mineral and Bone Disorder Updated

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Among other changes, the new KDIGO guidelines highlight the potential dangers of hypercalcemia.

Hip Fracture Rates Falling Among ESRD Patients

Hip Fracture Rates Falling Among ESRD Patients

From 2003 to 2011 there was a 26.7% decrease in in-hospital mortality rate after hip fracture.

Education Can Improve Phosphate Control

Education Can Improve Phosphate Control

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Patients receiving educational or behavioral interventions aimed at controlling hyperphosphatemia had an average reduction in phosphate of 0.23 mmol/L more than standard care patients.

Switch to an Iron-Based Binder Found to Improve Phosphorus Lowering

Switch to an Iron-Based Binder Found to Improve Phosphorus Lowering

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Converting hemodialysis patient to sucroferric oxyhydroxide from a previous binder increased the proportion of patients achieving target serum phosphorus levels.

Reducing Serum Phosphorus to Safer Target Range Ups Survival

Reducing Serum Phosphorus to Safer Target Range Ups Survival

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Survival improved by 12% when serum phosphate levels approached a safer target range.

Residual Kidney Function Predicts Mortality in CKD-MBD

Residual Kidney Function Predicts Mortality in CKD-MBD

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In a study of hemodialysis patients, mortality risk increased along with phosphorus level, particularly among patients with higher residual renal urea clearance.

Initial Low-Dose Etelcalcetide Feasible for SHPT Patients

Initial Low-Dose Etelcalcetide Feasible for SHPT Patients

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At 18 months, PTH levels were within target for 67% and 68% of participants who initiated etelcalcetide at 2.5 mg and 5 mg, respectively.

Sucroferric Oxyhydroxide Ups Phosphorus Control in SHPT

Sucroferric Oxyhydroxide Ups Phosphorus Control in SHPT

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Nearly twice as many patients achieved the target phosphorus range after a year of taking the phosphate binder, regardless of iPTH level.

Eliminating Phosphorus Food Additives Does Not Compromise Nutrition

Eliminating Phosphorus Food Additives Does Not Compromise Nutrition

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Replacing foods containing phosphorus-based additives with similar foods not containing these additives can control hyperphospatemia without interfering with nutritional status.

ALP Predicts Mortality in Peritoneal Dialysis Patients With CKD-MBD

ALP Predicts Mortality in Peritoneal Dialysis Patients With CKD-MBD

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Alkaline phosphatase was more strongly linked to mortality compared with other biomarkers of chronic kidney disease-mineral and bone disorder.

Elemental Calcium Intake High With Calcium-Based Binder Use

Elemental Calcium Intake High With Calcium-Based Binder Use

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In a study, 25.8% and 37.8% of calcium acetate and calcium carbonate users, respectively, exceeded the maximum recommended daily intake.

Iron-Based Phosphate Binder Safely Treats Anemia in CKD Patients

Iron-Based Phosphate Binder Safely Treats Anemia in CKD Patients

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In a study 52.1% of patients receiving ferric citrate attained a 1.0 g/dL or greater increase in hemoglobin compared with just 19.1% receiving placebo.

Phosphate Enemas Can Cause Hyperphosphatemia

Phosphate Enemas Can Cause Hyperphosphatemia

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Purgative products introduce 10 times the normal daily amount of phosphorus into the body.

Dialysis Patient Age May Affect Hyperphosphatemia Management

Dialysis Patient Age May Affect Hyperphosphatemia Management

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Younger patients are less likely to respond to treatment with sucroferric oxyhydroxide or sevelamer.

Prescribed Meds May Up Phosphate Burden in Hemodialysis Patients

Prescribed Meds May Up Phosphate Burden in Hemodialysis Patients

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Study implicates amlodipine, lisinopril, clonidine, acetaminophen, and omeprazole.

Phosphate Binder Switch Found to Benefit Peritoneal Dialysis Patients

Phosphate Binder Switch Found to Benefit Peritoneal Dialysis Patients

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The percentage of patients with serum phosphorus levels of 5.5 mg/dL and below more than doubled to 37.8% after 6 months of treatment with sucroferric oxyhydroxide.

Sucroferric Oxyhydroxide Helps More Hyperphosphatemia Pts Reach Target

Sucroferric Oxyhydroxide Helps More Hyperphosphatemia Pts Reach Target

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Patients also needed fewer phosphate binder pills over time.

ESRD Linked to Diet Soda Consumption

ESRD Linked to Diet Soda Consumption

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The risk of end-stage renal disease was 83% higher for those who drank more than 7 glasses of diet soft drinks weekly.

Intensive Hemodialysis Effective for Treating Hyperphosphatemia

Intensive Hemodialysis Effective for Treating Hyperphosphatemia

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It can sharply lower serum phosphorus levels and reduce dependence on phosphate binders.

Cutting Phosphorus Additives Reduces Hyperphosphatemia

Cutting Phosphorus Additives Reduces Hyperphosphatemia

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In a study, 69.7% of intervention patients attained serum phosphorus levels below 5.5 mg/dL, compared with just 18.5% of control patients.

Dietary Management May Aid Transition to Incremental HD

Dietary Management May Aid Transition to Incremental HD

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A low protein, low phosphorus diet plays an important role in the nutritional management of patients transitioning to once-weekly incremental hemodialysis.

Hyperphosphatemia Linked With Mortality in Septic AKI

Hyperphosphatemia Linked With Mortality in Septic AKI

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Hyperphosphatemia was associated with more than double the risk of death from any cause.

Teaching Low Phosphorus Cooking May Improve Hyperphosphatemia

Teaching Low Phosphorus Cooking May Improve Hyperphosphatemia

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Patients reduced dietary phosphorus without compromising protein intake.

Nutritional Databases Underreport Phosphorus Content

Nutritional Databases Underreport Phosphorus Content

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The USDA Standard Nutrient Reference Database, for example, listed phosphorus amounts for just 5 of 46 beverages.

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