Metabolic Abnormalities Tied to Lower Urinary Tract Symptoms

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Lower urinary tract symptoms in men
Lower urinary tract symptoms in men

HEALTH DAY - Metabolic abnormalities such as metabolic syndrome and insulin resistance are associated with lower urinary tract symptoms (LUTS), according to two studies published online ahead of print in BJU International.

Pourya Pashootan, from Saint-Louis Hospital in Paris, and colleagues examined the correlation between metabolic syndrome and the frequency and severity of LUTS in a cohort of 4,666 men aged 55 to 100 years. The researchers found that 51.5% of the patients had metabolic syndrome and 47% were treated for LUTS. Metabolic syndrome correlated significantly with treated LUTS (P < 0.001) and with the severity of LUTS (P < 0.001). There was an increase in the risk of being treated for LUTS with an increasing number of metabolic syndrome components.

In the other study, Serge Luke, MD, from Dunedin Hospital in New Zealand, and colleagues prospectively examined the effects of bariatric surgery on LUTS in a cohort of 86 patients. The researchers found that after surgery there was significant weight loss and reduction of body mass index. The overall symptom score was significantly reduced at six weeks (P < 0.001), and this was sustained at 1 year. The change in total symptoms score was predicted by total symptoms score at baseline, Homeostasis Model Assessment-insulin resistance, preoperative insulin level, and change in insulin level postoperatively, but not by weight loss.

"The study confirms the improvement in LUTS after weight loss but there is no correlation between the improvement and the time course or degree of weight loss," Dr. Luke and colleagues wrote.

The Pashootan study was supported by Astellas.

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