Higher Phosphate Reduces VLPD Anti-Proteinuric Response

Share this article:

Serum phosphate may interfere with the anti-proteinuric response to a very low protein diet (VLPD) in patients with chronic kidney disease (CKD), according to researchers.

In a study of 99 CKD patients with proteinuria who sequentially followed a low-protein diet (LPD) and a VLPD, 24-hour proteinuria decreased modestly in those who maintained relatively higher serum phosphate levels or relatively higher phosphaturia, investigators reported online ahead of print in Nephrology Dialysis Transplantation. Reducing phosphate burden may decrease proteinuria and slow progression of renal disease, Biagio R. Di Iorio, MD, of A. Landolfi' Hospital, Solofra, Avellino, Italy, and colleagues concluded.

The patients supplemented the diets with keto-analogues and followed each diet for periods longer than one year. The daily protein intake was 0.6 g/kg during LPD and 0.3 g/kg during VLPD.

Serum phosphate levels decreased to a significantly lower level during VLPD compared with LPD (3.2 vs. 3.7 mg/dL), an effect paralleled by a significant decline in phosphate excretion (649 mg/day with LPD and 462 mg/day with VLPD).

The median proteinuria during LPD was 1,910 mg/24 hour; this declined significantly to 987 mg/24 hour during VLPD. The investigators observed no significant change in estimated glomerular filtration rate (eGFR) during the two diet periods.

Share this article:
You must be a registered member of RUN to post a comment.
close

Next Article in Chronic Kidney Disease (CKD)

More in Chronic Kidney Disease (CKD)

Mediterranean Diet Lowers Chronic Kidney Disease (CKD) Risk

Mediterranean Diet Lowers Chronic Kidney Disease (CKD) Risk

Mediterranean diet is associated with a significantly lower risk of chronic kidney disease (CKD).

Exercise May Benefit Kids with Chronic Kidney Disease (CKD)

Exercise May Benefit Kids with Chronic Kidney Disease ...

Acute exercise may benefit children and adolescents with chronic kidney disease (CKD) via anti-inflammatory effects.

Aerobic Exercise Benefits Chronic Kidney Disease (CKD) Patients

Aerobic Exercise Benefits Chronic Kidney Disease (CKD) Patients

Chronic kidney disease (CKD) patients on hemodialysis experience greater quality of life and lower mortality with regular exercise.