High HDL May Raise Hemodialysis Patient Death Risk

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The inverse association is opposite of what is observed in the general population.
The inverse association is opposite of what is observed in the general population.

Elevated high-density lipoprotein (HDL) cholesterol protects against cardiovascular disease in the general population, but it may increase the risk of cardiovascular and all-cause mortality in hemodialysis patients, according to researchers.

 

In a study of 33,109 HD patients followed for up to 3 years, patients with HDL concentrations of 60 mg/dL or higher had a significant 8% and 5% increased risk of cardiovascular and all-cause mortality compared with patients with HDL concentrations of 30 mg/dL or higher but less than 60 mg/dL, researchers reported online ahead of print in Nephrology Dialysis Transplantation.

 

In addition, HDL levels below 30 mg/dL were associated with a significant 8% and 28% increased risk of all-cause and cardiovascular mortality. These associations were strongest in male patients, diabetics, and patients younger than 65 years.

 

The study, led by Kamyar Kalantar-Zadeh, MD, PhD, of the University of California Irvine, showed that HDL levels of 50 mg/dL or higher but less than 60 mg/dL offered the best survival.

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