High HDL May Raise Hemodialysis Patient Death Risk

The inverse association is opposite of what is observed in the general population.
The inverse association is opposite of what is observed in the general population.

Elevated high-density lipoprotein (HDL) cholesterol protects against cardiovascular disease in the general population, but it may increase the risk of cardiovascular and all-cause mortality in hemodialysis patients, according to researchers.

 

In a study of 33,109 HD patients followed for up to 3 years, patients with HDL concentrations of 60 mg/dL or higher had a significant 8% and 5% increased risk of cardiovascular and all-cause mortality compared with patients with HDL concentrations of 30 mg/dL or higher but less than 60 mg/dL, researchers reported online ahead of print in Nephrology Dialysis Transplantation.

 

In addition, HDL levels below 30 mg/dL were associated with a significant 8% and 28% increased risk of all-cause and cardiovascular mortality. These associations were strongest in male patients, diabetics, and patients younger than 65 years.

 

The study, led by Kamyar Kalantar-Zadeh, MD, PhD, of the University of California Irvine, showed that HDL levels of 50 mg/dL or higher but less than 60 mg/dL offered the best survival.

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