The guidelines recommend treatment strategies and state that evidence is insufficient to support therapy to lower uric acid to target levels.
Using the drug together with allopurinol helps more patients achieve target uric acid levels of less than 6 mg/dL.
The effect of gout on type 2 diabetes risk was more profound in women than men.
Highest vs lowest uric acid levels associated with a 2-fold increased risk of VTE.
A higher allopurinol dose was protective against renal failure in elderly allopurinol recipients.
Patients with inadequately controlled gout experience lower quality of life and report worse functioning.
Gout is associated with an elevated risk of comorbid conditions, especially hypertension and alcohol abuse.
Gout is associated with an elevated likelihood of both organic and psychogenic ED.
Gout increased the risk of erectile dysfunction in men by 21%.
Guidelines currently don't recognize gout as a risk factor for CKD and nephrolithiasis.
The incidence of gout among CKD patients was 6.82 per 1,000 persons per year compared to 2.43 for those without the disease.
Although 87% of patients met the criteria for urate-lowering treatment within 5 years, only 30% were prescribed the recommended treatment.
Analysis found that cigarette smoking was associated with a 24% overall reduction in gout risk.
Women with this form of arthritis are more susceptible to diabetes, researchers say.
Each 5-unit increment in BMI is associated with a 55% increased relative risk of gout.
Allopurinol therapy is not associated with beneficial cardiovascular outcomes in gout patients.
In a study, donors were 60% more likely to be diagnosed with gout than matched healthy controls.
Likelihood of a recurrent gout attack is greater under conditions of high temperature and/or low relative humidity.
Korean study also revealed an inverse association between serum homocysteine levels and renal function.
Individuals with first-degree relatives affected by the condition are twice as likely as those in the general population to experienced gout.
Elevated uric acid levels are associated with increased risks for hypertension, gout, and renal impairment.
Patients with gout experienced no clinically significant urate-lowering effects from an 8-week course of a modest dosage of vitamin C.
Many but not all cohort studies examining the relationship between hyperuricemia and CKD outcomes suggest they may be intertwined.
Adverse events included skin rash, gastrointestinal problems, and allopurinol hypersensitivity syndrome.
Gout prevalence is higher among patients with lower average estimated glomerular filtration rates or higher levels of albuminuria
The two are linked regardless of gender, race, and obesity.
An consumption over a two-year period found to decrease likelihood of a gout attack by 35%.
Data from 5,707 participants of the National Health and Nutrition Examination Survey (NHANES) 2007-2008 show that gout now affects 4% of Americans (8.3 million individuals), and hyperuricemia, 21% (43.3 million).
A case study involving a 58-year-old man with acute gout attacks and multiple comorbidities, including hypertension and hypercholesterolemia.
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