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Prostate Cancer Active Surveillance Use Low, But Increasing

Prostate Cancer Active Surveillance Use Low, But Increasing

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Use of active surveillance for very low-risk prostate cancer rose from 11.6% of patients in 2010 to 27.3% in 2013, study finds.

Chronic Kidney Disease Raises Tinnitus Risk

Chronic Kidney Disease Raises Tinnitus Risk

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Tinnitus is 3-fold more likely to develop in patients with versus without chronic kidney disease, new study shows.

Proximal PSA Predicts Prostate Cancer Metastasis Risk

Proximal PSA Predicts Prostate Cancer Metastasis Risk

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PSA levels of 10 ng/mL or higher in men who have biochemically recurrent PCa after radical prostatectomy and a PSADT less than 12 months are at imminent risk for metastatic disease.

Intensive BP Control May Reduce Death Risk in CKD Patients

Intensive BP Control May Reduce Death Risk in CKD Patients

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Targeting and treating systolic blood pressure to a lower range was associated with a 14% decreased risk of death, meta-analysis shows.

Upfront Cabozantinib for Advanced RCC Improves Outcomes

Upfront Cabozantinib for Advanced RCC Improves Outcomes

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Cabozantinib reduced the risk of disease progression or death compared with sunitinib among patients with previously untreated advanced renal cell carcinoma.

Arteriovenous Fistulas Not Always the Best Option

Arteriovenous Fistulas Not Always the Best Option

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Despite low infection rates, AVFs have a high risk of maturation failure and abandonment.

Prostate Cancer Screening Saves Lives, New Analysis Shows

Prostate Cancer Screening Saves Lives, New Analysis Shows

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A European trial found a survival benefit from PCa screening and a US trial did not, but a new analysis finds that both trials provide compatible evidence that screening decreases PCa mortality.

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

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Liraglutide-treated patients were 22% less likely than placebo recipients to experience a composite outcome of renal events.

Study Finds No Link Between Marijuana Use and Kidney Function

Study Finds No Link Between Marijuana Use and Kidney Function

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No significant association found between marijuana use and change in estimated glomerular filtration rate or development of albuminuria.

Cancer Drug Slows ADPKD Cyst Growth, Study Finds

Cancer Drug Slows ADPKD Cyst Growth, Study Finds

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Bosutinib treatment was associated with a 66% decrease in the annual rate of kidney enlargement.

Urologist Ownership of IMRT Linked to Its Greater Use for PCa

Urologist Ownership of IMRT Linked to Its Greater Use for PCa

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Patients are more likely to receive intensity-modulated radiation therapy if they are managed by urology practices with an ownership interest in the modality, study finds.

Researchers: Iron-based Binders Best for Hyperphosphatemia

Researchers: Iron-based Binders Best for Hyperphosphatemia

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Of 7 phosphate binders, iron-based agents were optimal when efficacy and safety are considered.

Study: Cystectomy Complication Rate Not Improving

Study: Cystectomy Complication Rate Not Improving

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Researchers find no significant change in overall complication rate from 2010 to 2015, but hospital length of stay and need for transfusion have declined.

Cancer Patient Self-Reporting Reliable and Feasible, Studies Show

Cancer Patient Self-Reporting Reliable and Feasible, Studies Show

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Prostate cancer patients accurately report their comorbidities, and participants in cancer clinical trials report more adverse events than trial investigators.

Not All High-Risk Prostate Cancers Are the Same

Not All High-Risk Prostate Cancers Are the Same

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Men with 1 high-risk factor experience better outcomes following treatment than those with 2 or 3 high-risk factors, study finds.

Blacks Less Likely to Undergo Definitive Prostate Cancer Therapy

Blacks Less Likely to Undergo Definitive Prostate Cancer Therapy

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Study of men with intermediate- or high-risk prostate cancer finds facility-level racial disparity in use of definitive treatment.

Timing of PSA Nadir Post-RP Predicts Biochemical Recurrence Risk

Timing of PSA Nadir Post-RP Predicts Biochemical Recurrence Risk

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A detectable PSA nadir combined with shorter time to nadir after prostate cancer surgery is associated with a higher risk of biochemical recurrence.

Olfactory Deficits, Malnutrition Markers Linked in CKD, ESRD Patients

Olfactory Deficits, Malnutrition Markers Linked in CKD, ESRD Patients

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Pilot study suggests intranasal theophylline may be worth further investigation as a treatment.

For Treating Uremic Pruritus, Evidence is Strongest for Gabapentin

For Treating Uremic Pruritus, Evidence is Strongest for Gabapentin

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Except for gabapentin, evidence for 38 other treatments is weak and limited by small studies with a high risk of bias, new review finds.

Active Surveillance for Intermediate-Risk PCa May Be Unsafe

Active Surveillance for Intermediate-Risk PCa May Be Unsafe

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Nearly 1 in 3 patients diagnosed with Gleason 3+4 favorable intermediate-risk prostate cancer had their disease upgraded or upstaged at radical prostatectomy.

Proteomics Identifies CKD Predictors

Proteomics Identifies CKD Predictors

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The investigators assessed proteomic profiling of 80 proteins using a multiplex assay.

Women Less Likely to Initiate Hemodialysis With an AV Fistula

Women Less Likely to Initiate Hemodialysis With an AV Fistula

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The odds of starting hemodialysis with an arteriovenous fistula are 31% lower for women compared with men.

Erectile Dysfunction May Predict Development of Parkinson's Disease

Erectile Dysfunction May Predict Development of Parkinson's Disease

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A new study found a 52% higher risk for the future development of Parkinson's disease among men with erectile dysfunction.

Mortality Up for ER Patients Discharged With AKI

Mortality Up for ER Patients Discharged With AKI

Higher mortality was seen in association with an emergency department discharge with acute kidney injury vs no acute kidney injury.

Add-on Sevelamer Therapy May Improve Hemodialysis Patient Survival

Add-on Sevelamer Therapy May Improve Hemodialysis Patient Survival

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Use of sevelamer was associated with a 14% decreased risk of death compared with non-use.

Vasectomy Poses Minimal Risk of Prostate Cancer

Vasectomy Poses Minimal Risk of Prostate Cancer

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Researchers calculated that the absolute increase in lifetime risk of prostate cancer associated with vasectomy was just 0.6%.

Ferritin Spike Soon After Hemodialysis Initiation Ups Mortality Risk

Ferritin Spike Soon After Hemodialysis Initiation Ups Mortality Risk

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Up to a 49% higher risk of death observed in patients who had a 400 ng/mL increase in serum ferritin from baseline values compared with patients who had relatively stable ferritin levels.

Optimal Iron Status for Hemodialysis Patients Reported

Optimal Iron Status for Hemodialysis Patients Reported

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Japanese researchers conclude that a serum ferritin level below 90 ng/mL and TSAT of 20% or higher was optimal for achieving a hemoglobin level of 10 g/dL or higher.

Radical Prostatectomy Use for High-Risk Prostate Cancer Rises Sharply

Radical Prostatectomy Use for High-Risk Prostate Cancer Rises Sharply

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Over a 10-year period, radical prostatectomy use increased steadily while radiotherapy use declined

Prostatic Urethral Lift Benefits Durable Out to 5 Years

Prostatic Urethral Lift Benefits Durable Out to 5 Years

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Patients who underwent the minimally invasive procedure had a 36%, 50%, and 44% improvement in IPSS, quality of life, and peak flow rate, respectively, at 5 years.

Prostate Atrophy, Inflammation Associated With Lower PCa Risk

Prostate Atrophy, Inflammation Associated With Lower PCa Risk

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Both findings on biopsy also predict a lower odds of high-grade cancer.

Symptomatic Bladder Cancer Recurrence Linked With Worse Survival

Symptomatic Bladder Cancer Recurrence Linked With Worse Survival

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Symptomatic recurrence was associated with a nearly 2-fold higher risk of death from the time of recurrence versus surveillance-detected recurrence.

Negative Confirmatory Biopsy a Good Sign in Prostate Cancer AS

Negative Confirmatory Biopsy a Good Sign in Prostate Cancer AS

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Prostate cancer patients on active surveillance who have no cancer found on confirmatory biopsy have a reduced risk of grade and volume reclassification.

Intensive Blood Pressure Reduction Benefits CKD Patients

Intensive Blood Pressure Reduction Benefits CKD Patients

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CKD patients treated to a target systolic blood pressure of less than 120 mm Hg were 28% less likely to die early.

Non-Dialysis CKD Patients With Anemia Have More CVD, Worse QoL

Non-Dialysis CKD Patients With Anemia Have More CVD, Worse QoL

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Anemic patients were 41% and 80% more likely to have coronary artery disease and peripheral artery disease than non-anemic patients.

CKD Linked to High Intake of Red, Processed Meat

CKD Linked to High Intake of Red, Processed Meat

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Chronic kidney disease stage 3 is 23% more likely to develop in individuals in the highest versus lowest quintile of consumption of red and processed meat.

Post-RP Radiotherapy Benefits Selected Men With Elevated PSA

Post-RP Radiotherapy Benefits Selected Men With Elevated PSA

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Radiotherapy for prostate cancer patients with persistently elevated PSA after radical surgery improved survival only among those with worse pathologic characteristics.

Erectile Dysfunction Risk Higher in Gout Patients

Erectile Dysfunction Risk Higher in Gout Patients

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The risk for developing erectile dysfunction is 15% higher among men with than without gout.

Gout Patient Hospitalizations Soar

Gout Patient Hospitalizations Soar

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All-cause hospitalizations in the US increased 410% from 1993 to 2014 among gout sufferers compared with 4.8% in the general population.

Review Supports Sodium Thiosulfate Use for Calciphylaxis

Review Supports Sodium Thiosulfate Use for Calciphylaxis

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Patients often received sodium thiosulfate with other therapies.

Novel Parathyroidectomy Procedure May Result in Durably Low PTH

Novel Parathyroidectomy Procedure May Result in Durably Low PTH

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Typically, about 2% to 20% of SHPT patients experience recurrence or persistence after conventional parathyroidectomy procedures, likely due to residual parathyroid tissue.

Nephrology Referrals May Not Benefit Elderly CKD Patients

Nephrology Referrals May Not Benefit Elderly CKD Patients

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Most elderly CKD patients ultimately will not require or desire renal replacement therapy.

Men Need Better Understanding of PCa Genetic Test Results

Men Need Better Understanding of PCa Genetic Test Results

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Some men who undergo multigene testing for inherited prostate cancer misinterpret findings of variants of uncertain significance.

Gout Risk Is Lower Among Healthier Eaters

Gout Risk Is Lower Among Healthier Eaters

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A DASH-style diet is associated with a reduced risk of gout, whereas a Western diet is associated with a higher risk.

Post-Transplant Infections, Cancer Do Not Up Mortality

Post-Transplant Infections, Cancer Do Not Up Mortality

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Opportunistic viral and fungal infections or malignancies develop in 34% of kidney transplant recipients, but these complications do not affect patient or graft survival.

Accepting High-Risk Kidneys Is Better Than Waiting

Accepting High-Risk Kidneys Is Better Than Waiting

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High-KDPI kidneys can improve the likelihood of a functioning graft compared with waiting for a superior kidney.

Kidney Donor-Recipient CMV Matching Is a Promising Strategy

Kidney Donor-Recipient CMV Matching Is a Promising Strategy

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Researchers report that matching deceased kidney donors and kidney recipients by cytomegalovirus serostatus optimizes high- and low-risk profiles.

Living Kidney Donor Graft Survival Improving

Living Kidney Donor Graft Survival Improving

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Five-year graft survival rates among recipients of kidneys from living donors increased from 76.6% in 1985-1894 to 85.4% in 2009-2015.

Timing of Renal Replacement Therapy Initiation in AKI

Timing of Renal Replacement Therapy Initiation in AKI

Evidence to date provides no clear answer as to whether early or delayed RRT is the best approach.

No Adverse Outcomes Following Bundling

No Adverse Outcomes Following Bundling

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Action taken to mitigate risks associated with ESA use and changes in payment policy did not result in a relative increase in death or major cardiovascular events.

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