First-in-Class Diabetes Drug Approved

Share this article:

The FDA has approved Invokana (canagliflozin), a first-in-class medication that helps to improve glycemic control in adults with type 2 diabetes.

Manufactured by Janssen Pharmaceuticals based in Raritan, N.J., canagliflozin is a sodium-glucose co-transporter 2 inhibitor that blocks reabsorption of glucose in the kidney, increases glucose excretion, and lowers blood glucose levels.

The drug was studied in combination with other treatments for type 2 diabetes, including metformin, sulfonylurea, pioglitazone, and insulin across nine clinical trials that included 10,285 patients. From the trials, researchers noted an improvement in hemoglobin A1c levels and fasting plasma glucose levels in addition to reduced body weight and systolic blood pressure.

Share this article:
You must be a registered member of RUN to post a comment.

More in Diabetes

Grape Seed Extract May Lower Blood Sugar in Diabetes Mellitus

Grape Seed Extract May Lower Blood Sugar in ...

Grape seed extract may help to lower blood sugar and glucose levels in patients with diabetes mellitus.

Intensive Glucose Control in Diabetics Offers No Survival Advantage

Intensive Glucose Control in Diabetics Offers No Survival ...

But targeting an HbA1c level below 6.5% is associated with a decreased risk of end-stage renal disease.

Nasal Insulin Helps Brain Function in Type 2 Diabetes

Nasal Insulin Helps Brain Function in Type 2 ...

Findings in older adults with type 2 diabetes treated with single dose of intranasal insulin.