Fibrosis with Inflammation Worsens Transplant Outcomes

Share this article:

A combination of fibrosis and inflammation one year after kidney transplantation is associated with reduced graft function and graft survival, according to an online report in the Journal of the American Society of Nephrology.

In a study of 151 recipients of living-donor kidneys, Mark D. Steagall, MD, and co-investigators found that those with both fibrosis and inflammation had a decline in glomerular filtration rate and reduced graft survival as well as a rejection-like gene expression signature. Patients with normal histology or fibrosis alone had stable kidney function between one and five years.

“Early interventions aimed at altering rejection-like inflammation may improve long-term survival of kidney allografts,” the authors concluded.

Share this article:
You must be a registered member of RUN to post a comment.
close

Next Article in Transplantation

More in Transplantation

Gender Disparity in Desire for Living Kidney Transplant

Gender Disparity in Desire for Living Kidney Transplant

Black female hemodialysis patients less likely to want living transplant; more likely to receive offer.

Survival Benefit of Expanded Criteria Kidneys Probed

Survival Benefit of Expanded Criteria Kidneys Probed

For some highly sensitized patients, expanded criteria donor kidneys do not confer a survival edge over standard criteria donor kidneys.

Circulatory Death, Brain-Dead Donor Kidneys Offer Equivalent Outcomes

Circulatory Death, Brain-Dead Donor Kidneys Offer Equivalent Outcomes

Kidney transplanted from brain-dead donors or those who died from circulatory causes are associated with similar patient and graft survival.