Testosterone Found to Boost Efficacy of PDE5 Inhibitors

To optimize outcomes, researchers suggest testosterone assays in men who fail to respond to PDE5 inhibitors.
To optimize outcomes, researchers suggest testosterone assays in men who fail to respond to PDE5 inhibitors.

Testosterone use can increase the efficacy of phosphodiesterase type 5 (PDE5) inhibitors in men who have erectile dysfunction that does not respond to the drugs, according to a recent meta-analysis published online in Expert Opinion on Pharmacotherapy.

Although the combination of testosterone replacement and PDE5 inhibitors showed greater efficacy in non-controlled studies compared with controlled studies, the authors recommend consideration of testosterone assays in men who fail to respond to PDE5 inhibitors in an effort to optimize outcomes.

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