Calcified Peyronie's Disease Plaques May Predict Surgery

CHICAGO—Men with severe calcified Peyronie's disease (PD) plaques are more likely to progress to surgical treatment than men with non-calcified plaques, researchers reported at the World Meeting on Sexual Medicine.

Laurence Levine, MD, and James Rybak, MD, and colleagues at Rush University Medical Center in Chicago reviewed data from 792 men presenting with PD from 1993 to 2009 and identified 98 who had have PD plaque calcification detected by ultrasound.

A urologist evaluated the degree of calcification, grading the calcification as follows: grade 1 (less than 0.3 cm thick), grade 2 (greater than 0.3 cm but less than 1.5 cm thick), and grade 3 (greater than 1.5 cm wide or the presence of two or plaques more than 1.0 cm thick). These men were compared with a control group of 236 PD patients with non-calcified plaques; controls were matched for age, disease duration, date of presentation, and mean curvature.

In the calcified plaque group, 41% of patients had grade 1 calcification, 28% had grade 2, and 32% had grade 3. The investigators found that 23% of patients with grade 1, 32% of those with grade 2, and 55% of men with grade 3 calcification progressed to surgery. In the matched control group, 34% progressed to surgery. Men with grade 3 calcification had greater than twofold increased likelihood of electing surgical intervention for PD compared with controls.

Calcification by itself was not a significant predictor of progression to surgery.

The meeting is cosponsored by the International Society for Sexual Medicine and the Sexual Medicine Society of North America.

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