Increased Hypertension Risk Found in Live Kidney Donors

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MUNICH, GERMANY—Live kidney donors may experience an increase in blood pressure following nephrectomy, new data suggest.

Geir Mjøen, MD, and colleagues at Oslo University Hospital in Norway reviewed files from 908 live kidney donors. Of these, 573 had one-year follow-up data, which were available from the Norwegian Live Donor Registry. The subjects had a mean age of 47.7 years, a mean BMI of 25.3 kg/m2, and mean creatinine clearance of 115.9 mL/min.

The group´s mean systolic and diastolic pressures rose from 122.8 and 76.5 mm Hg, respectively, at baseline, to 124.4 and 78 at one year after donation, according to findings presented at the European Renal Association-European Dialysis and Transplant Association 2010 Congress.

Prior to donation, 16 subjects (2.7%) had hypertension, and two were on medication. At one year, 68 (11.9%) had hypertension, and 13 were on medication.

Of the 16 donors who were hypertension prior to donation, six were normotensive. Individuals with a BMI above 25 and those older than 60 years were at nearly twofold and fourfold increased odds for hypertension. Pre-nephrectomy hypertension was associated with a 9.5 increased odds. These findings indicate a need for close follow-up of these subgroups, the investigators concluded.

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