Fracture Risk Varies by Renal Replacement Therapy

HD patients are at higher risk than peritoneal dialysis and renal transplant recipients.
HD patients are at higher risk than peritoneal dialysis and renal transplant recipients.

AMSTERDAM—Hemodialysis patients (HD) are at higher risk of fractures than renal transplant recipients and patients on peritoneal dialysis (PD), investigators reported at the 51st Congress of the European Renal Association-European Dialysis and Transplant Association.

Investigators in the U.K. reviewed the records of 2,096 patients on renal replacement therapy (RRT) in western Scotland. Of these, 1,081 (51.6%) were kidney transplant recipients, 907 (43.3%) were HD patients, and 108 (5.2%) were PD patients. The patients had a mean age of 50.4, 61.8, and 57.9 years, respectively. The median duration of follow-up was 1,112, 1,086, and 1,126 days, respectively.

A total of 337 fractures occurred in the study population, for an overall incidence of 0.062 fractures per patient year. Compared with the kidney transplant and PD groups, the risk of fracture in the HD group was 2.6 times and 1.7 times greater.

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